Study of tree shrew biology and models: A booming and prosperous field for biomedical research [0.03%]
树鼩生物学及模型研究：生物医药研究的新兴和繁荣领域
Yong-Gang Yao,Li Lu,Rong-Jun Ni et al.
Yong-Gang Yao et al.
The tree shrew ( Tupaia belangeri) has long been proposed as a suitable alternative to non-human primates (NHPs) in biomedical and laboratory research due to its close evolutionary relationship with primates. In recent years, significant ad...
Jing Cao,Yun-Wu Zhang
Jing Cao
NLRP3-mediated autophagy dysfunction links gut microbiota dysbiosis to tau pathology in chronic sleep deprivation [0.03%]
慢性睡眠剥夺中肠道菌群失调通过NLRP3介导的自噬功能障碍与tau病理相连
Na Zhao,Xiu Chen,Qiu-Gu Chen et al.
Na Zhao et al.
Emerging evidence indicates that sleep deprivation (SD) can lead to Alzheimer's disease (AD)-related pathological changes and cognitive decline. However, the underlying mechanisms remain obscure. In the present study, we identified the exis...
SIL1 improves cognitive impairment in APP23/PS45 mice by regulating amyloid precursor protein processing and Aβ generation [0.03%]
SIL1通过调控淀粉样前体蛋白加工和Aβ生成改善APP23/PS45小鼠认知障碍
Qunxian Wang,Yanshuang Jiang,Zijun Meng et al.
Qunxian Wang et al.
SIL1, an endoplasmic reticulum (ER)-resident protein, is reported to play a protective role in Alzheimer's disease (AD). However, the effect of SIL1 on amyloid precursor protein (APP) processing remains unclear. In this study, the role of S...
Genetically modified pigs with CD163 point mutation are resistant to HP-PRRSV infection [0.03%]
携带CD163点突变的基因编辑猪对高致病性猪繁殖与呼吸综合征病毒具有抗性
Ying Liu,Lin Yang,Hong-Yong Xiang et al.
Ying Liu et al.
Porcine reproductive and respiratory syndrome (PRRS) is a globally prevalent contagious disease caused by the positive-strand RNA PRRS virus (PRRSV), resulting in substantial economic losses in the swine industry. Modifying the CD163 SRCR5 ...
P J Hore
P J Hore
Jing Zhang,Yafei Chang,Peng Zhang et al.
Jing Zhang et al.
Magnetic sense, or termed magnetoreception, has evolved in a broad range of taxa within the animal kingdom to facilitate orientation and navigation. MagRs, highly conserved A-type iron-sulfur proteins, are widely distributed across all phyl...
Microplastic exposure disturbs sleep structure, reduces lifespan, and decreases ovary size in Drosophila melanogaster [0.03%]
微塑料暴露会影响果蝇的睡眠结构、缩短寿命并减小卵巢大小
Wei Yan,Zi-Jie Li,Zi-Yi Lin et al.
Wei Yan et al.
The organ-specific toxicity resulting from microplastic (MP) exposure has been extensively explored, particularly concerning the gut, liver, testis, and lung. However, under natural conditions, these effects are not restricted to specific o...
Metabolomic-based analysis reveals bile acid-mediated ovarian failure induced by low temperature in zebrafish [0.03%]
基于代谢组学的分析揭示了低温通过胆汁酸介导诱导斑马鱼卵巢衰竭
Wen-Hao Li,Zhi-Qiang Li,Meng-Di Bu et al.
Wen-Hao Li et al.
As ectotherms, fish are highly sensitive to temperature fluctuations, which can profoundly impact their reproductive cycles. In this study, we investigated the fertility and histological characteristics of zebrafish ( Danio rerio) ovaries e...
Engineered AAV13 variants with enhanced transduction and confined spread [0.03%]
具有增强的转导和限域扩散的工程AAV13变异体
Neng-Song Luo,Yu-Xiang Cai,Zeng-Peng Han et al.
Neng-Song Luo et al.
Precise targeting of specific regions within the central nervous system (CNS) is crucial for both scientific research and gene therapy in the context of brain diseases. Adeno-associated virus 13 (AAV13) is known for its restricted diffusion...