Comparative DNA methylation reveals epigenetic adaptation to high altitude in snub-nosed monkeys [0.03%]
DNA甲基化比较研究揭示了金丝猴的表观遗传高原适应机制
Ling Wang,Wei-Qiang Liu,Juan Du et al.
Ling Wang et al.
DNA methylation plays a crucial role in environmental adaptations. Here, using whole-genome bisulfite sequencing, we generated comprehensive genome-wide DNA methylation profiles for the high-altitude Yunnan snub-nosed monkey ( Rhinopithecus...
Bat-derived oligopeptide LE6 inhibits the contact-kinin pathway and harbors anti-thromboinflammation and stroke potential [0.03%]
蝙蝠源寡肽LE6抑制接触激肽途径并具有抗血栓炎症和治疗卒中的潜力
Li-Na Cha,Juan Yang,Jin-Ai Gao et al.
Li-Na Cha et al.
Thrombosis and inflammation are primary contributors to the onset and progression of ischemic stroke. The contact-kinin pathway, initiated by plasma kallikrein (PK) and activated factor XII (FXIIa), functions bidirectionally with the coagul...
Mandarin fish von Hippel-Lindau protein regulates the NF-κB signaling pathway via interaction with IκB to promote fish ranavirus replication [0.03%]
瓦氏巨鱼沼蛙HIF-1α通过与IκB的相互作用调节NF-κB信号通路以促进鱼类ranavirus复制
Zhi-Min Li,Xiao-Wei Qin,Qi Zhang et al.
Zhi-Min Li et al.
The von Hippel-Lindau tumor suppressor protein (VHL), an E3 ubiquitin ligase, functions as a critical regulator of the oxygen-sensing pathway for targeting hypoxia-inducible factors. Recent evidence suggests that mammalian VHL may also be c...
Qiong Wu,Alexander G Radchenko,Michael S Engel et al.
Qiong Wu et al.
Most described Mesozoic ants belong to stem groups that existed only during the Cretaceous period. Previously, the earliest known crown ants were dated to the Turonian (Late Cretaceous, ca. 94-90 million years ago (Ma)) deposits found in th...
Anti-infective immune functions of type IV interferon in grass carp ( Ctenopharyngodon idella): A novel antibacterial and antiviral interferon in lower vertebrates [0.03%]
四型干扰素的抗感染免疫功能-鱼类新型的具有抗细菌和抗病毒活性的干扰素分子
Yuchen Liu,Wentao Zhu,Yanqi Zhang et al.
Yuchen Liu et al.
Type IV interferon (IFN-υ) is a recently discovered cytokine crucial for host defense against viral infections. However, the role and mechanisms of IFN-υ in bacterial infections remain unexplored. This study investigated the antibacterial...
Tumor necrosis factor α deficiency promotes myogenesis and muscle regeneration [0.03%]
肿瘤坏死因子α缺乏促进肌细胞生成和肌肉再生
Yu Fu,Jing-Ru Nie,Peng Shang et al.
Yu Fu et al.
Tumor necrosis factor α (TNFα) exhibits diverse biological functions; however, its regulatory roles in myogenesis are not fully understood. In the present study, we explored the function of TNFα in myoblast proliferation, differentiation...
TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance [0.03%]
Tax1bp1和Fip200通过非经典自噬作用协同去除p62聚集物以维持小鼠神经干细胞数量
Yi-Fu Zhu,Rong-Hua Yu,Shuai Zhou et al.
Yi-Fu Zhu et al.
Autophagy plays a pivotal role in diverse biological processes, including the maintenance and differentiation of neural stem cells (NSCs). Interestingly, while complete deletion of Fip200 severely impairs NSC maintenance and differentiation...
Rotating magnetic field inhibits Aβ protein aggregation and alleviates cognitive impairment in Alzheimer's disease mice [0.03%]
旋转磁场可抑制阿尔茨海默病小鼠中Aβ蛋白聚集并缓解认知障碍
Ruo-Wen Guo,Wen-Jing Xie,Biao Yu et al.
Ruo-Wen Guo et al.
Amyloid beta (Aβ) monomers aggregate to form fibrils and amyloid plaques, which are critical mechanisms in the pathogenesis of Alzheimer's disease (AD). Given the important role of Aβ1-42 aggregation in plaque formation, leading to brain ...
Updated roles of the gut microbiota in exploring shrimp etiology, polymicrobial pathogens, and disease incidence [0.03%]
肠道微生物在探索虾病发病学、多微生物病原和疾病发生率方面的作用更新
Jin-Bo Xiong,Hao-Nan Sha,Jiong Chen
Jin-Bo Xiong
Litopenaeus vannamei is the most extensively cultured shrimp species globally, recognized for its scale, production, and economic value. However, its aquaculture is plagued by frequent disease outbreaks, resulting in rapid and massive morta...
Myotis bat STING attenuates aging-related inflammation in female mice [0.03%]
吸血蝙蝠STING能减轻小鼠年龄相关的炎症反应
Xi Wang,Jing-Kun Jia,Qi Wang et al.
Xi Wang et al.
Bats, notable as the only flying mammals, serve as natural reservoir hosts for various highly pathogenic viruses in humans (e.g., SARS-CoV and Ebola virus). Furthermore, bats exhibit an unparalleled longevity among mammals relative to their...