Chromosome-level genome and population genomics of the intermediate horseshoe bat ( Rhinolophus affinis) reveal the molecular basis of virus tolerance in Rhinolophus and echolocation call frequency variation [0.03%]
中华姬鼠蹄蝠染色体水平基因组及群体基因组学揭示了蹄蝠病毒耐受性的分子机制和回声定位叫声频率变异
Le Zhao,Jiaqing Yuan,Guiqiang Wang et al.
Le Zhao et al.
Horseshoe bats (genus Rhinolophus, family Rhinolophidae) represent an important group within chiropteran phylogeny due to their distinctive traits, including constant high-frequency echolocation, rapid karyotype evolution, and unique immune...
Synergistic effects of Pleistocene geological and climatic events on complex phylogeographic history of widespread sympatric species of Megaloptera in East Asia [0.03%]
第四纪气候变化与地质事件协同作用于东亚广布性大型缺翅甲的复杂谱系地理格局形成
Ai-Li Lin,Ming-Ming Zou,Li-Jun Cao et al.
Ai-Li Lin et al.
Unraveling the phylogeographic histories of species remains a key endeavor for comprehending the evolutionary processes contributing to the rich biodiversity and high endemism found in East Asia. In this study, we explored the phylogeograph...
foxl2l is a germ cell-intrinsic gatekeeper of oogenesis in zebrafish [0.03%]
Foxl2l是斑马鱼卵子发生过程中的固有调控因子
Zhiqin Ren,Ding Ye,Naike Su et al.
Zhiqin Ren et al.
Zebrafish serve as a valuable model organism for studying germ cell biology and reproductive processes. The AB strain of zebrafish is proposed to exhibit a polygenic sex determination system, where most males initially develop juvenile ovar...
Overexpression of Kdm6b induces testicular differentiation in a temperature-dependent sex determination system [0.03%]
Kdm6b过表达通过温度依赖性的方式诱导性别分化
Qiran Chen,Wei Sun,Lin Jin et al.
Qiran Chen et al.
In reptiles, such as the red-eared slider turtle ( Trachemys scripta elegans), gonadal sex determination is highly dependent on the environmental temperature during embryonic stages. This complex process, which leads to differentiation into...
Single nucleus/cell RNA-seq of the chicken hypothalamic-pituitary-ovarian axis offers new insights into the molecular regulatory mechanisms of ovarian development [0.03%]
鸡生殖轴单细胞/核RNA测序揭示卵巢发育分子调控机制的新见解
Dong Leng,Bo Zeng,Tao Wang et al.
Dong Leng et al.
The hypothalamic-pituitary-ovarian (HPO) axis represents a central neuroendocrine network essential for reproductive function. Despite its critical role, the intrinsic heterogeneity within the HPO axis across vertebrates and the complex int...
Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in humans and mice [0.03%]
人类和小鼠的CCDC146同源突变导致精子寡弱畸形症
Jing-Wei Ye,Tanveer Abbas,Jian-Teng Zhou et al.
Jing-Wei Ye et al.
Infertility represents a significant health concern, with sperm quantity and quality being crucial determinants of male fertility. Oligoasthenoteratozoospermia (OAT) is characterized by reduced sperm motility, lower sperm concentration, and...
CCDC181 is required for sperm flagellum biogenesis and male fertility in mice [0.03%]
CCDC181对小鼠精子鞭毛生成及雄性生育能力是必需的
Xiang-Jun Zhang,Xiao-Ning Hou,Jian-Teng Zhou et al.
Xiang-Jun Zhang et al.
The structural integrity of the sperm flagellum is essential for proper sperm function. Flagellar defects can result in male infertility, yet the precise mechanisms underlying this relationship are not fully understood. CCDC181, a coiled-co...
Cadherin-18 loss in prospermatogonia and spermatogonial stem cells enhances cell adhesion through a compensatory mechanism [0.03%]
纤连蛋白-18缺失通过补偿机制增强 prospermatogonia 和精原干细胞的细胞粘附性
Xiao-Xiao Li,Dan-Chen Zhang,Yan Wang et al.
Xiao-Xiao Li et al.
Extracellular membrane proteins are crucial for mediating cell attachment, recognition, and signal transduction in the testicular microenvironment, particularly germline stem cells. Cadherin 18 (CDH18), a type II classical cadherin, is prim...
PRSS50-mediated inhibition of MKP3/ERK signaling is crucial for meiotic progression and sperm quality [0.03%]
PRSS50通过抑制MKP3/ERK信号通路对减数分裂进程和精子质量的作用至关重要
Chun-Xue Niu,Jia-Wei Li,Xiao-Li Li et al.
Chun-Xue Niu et al.
Serine protease 50 (PRSS50/TSP50) is highly expressed in spermatocytes. Our study investigated its role in testicular development and spermatogenesis. Initially, PRSS50 knockdown was observed to impair DNA synthesis in spermatocytes. To fur...
Chromosome-level genome assembly of the glass catfish ( Kryptopterus vitreolus) reveals molecular clues to its transparent phenotype [0.03%]
玻璃猫鱼（Kryptopterus vitreolus）染色体水平基因组组装揭示其透明表型的分子线索
Chao Bian,Rui-Han Li,Zhi-Qiang Ruan et al.
Chao Bian et al.
Glass catfish ( Kryptopterus vitreolus) are notable in the aquarium trade for their highly transparent body pattern. This transparency is due to the loss of most reflective iridophores and light-absorbing melanophores in the main body, alth...