LncRNA GTL2 regulates myoblast proliferation and differentiation via the PKA-CREB pathway in Duolang sheep [0.03%]
GTL2长链非编码RNA通过PKA-CREB信号通路调控都想羊肌细胞增殖及分化
Qian Chen,Jing-Jing Bao,He-Chun Zhang et al.
Qian Chen et al.
Long non-coding RNAs (lncRNAs), which are RNA molecules longer than 200 nucleotides that do not encode proteins, are implicated in a variety of biological processes, including growth and development. Despite research into the role of lncRNA...
Yao-Hao Tang,Xing Zhang,Zong-Cai Dai et al.
Yao-Hao Tang et al.
The CRISPR-Cas13 system, an RNA-guided editing tool, has emerged as a highly efficient and stable RNA editing technique. Although the CRISPR-Cas13 system has been developed in several insect species, its application in lepidopterans has not...
Qing-Zhang Tuo,Peng Lei
Qing-Zhang Tuo
Stroke is a major cause of death and disability worldwide, with the majority of cases resulting from ischemic events due to arterial occlusion. Current therapeutic approaches focus on rapid reperfusion through intravenous thrombolysis and i...
Yong-Gang Yao,Peng Shi
Yong-Gang Yao
Maternal sleep deprivation disrupts glutamate metabolism in offspring rats [0.03%]
母体睡眠剥夺会扰乱后代大鼠的谷氨酸代谢
Wen-Ting He,Dong-Xu Li,Jin-Hua Fan et al.
Wen-Ting He et al.
Maternal sleep deprivation (MSD) has emerged as a significant public health concern, yet its effects on offspring metabolism remain poorly understood. This study investigated the metabolomic implications of MSD on offspring cognitive develo...
Convergent evolution in high-altitude and marine mammals: Molecular adaptations to pulmonary fibrosis and hypoxia [0.03%]
高原和海洋哺乳动物的趋同进化：肺纤维化和低氧条件下的分子适应性
Bo-Xiong Guo,Ya Zhang,Xiao-Yu Sun et al.
Bo-Xiong Guo et al.
High-altitude and marine mammals inhabit distinct ecosystems but share a common challenge: hypoxia. To survive in low-oxygen environments, these species have evolved similar phenotypic pulmonary adaptations, characterized by a high density ...
Nature's disguise: Empirical demonstration of dead-leaf masquerade in Kallima butterflies [0.03%]
自然的伪装：飞鸟林树叶天蛾的枯叶拟态的实证研究
Zeng-Tao Zhang,Long Yu,Hai-Zhen Chang et al.
Zeng-Tao Zhang et al.
Animals deploy diverse color-based defenses against predators, including crypsis, mimicry, aposematism, and masquerade. While crypsis, mimicry, aposematism have been extensively studied, the strategy of masquerade-where organisms imitate in...
Pancreatic agenesis and altered m6A methylation in the pancreas of PDX1-mutant cynomolgus macaques [0.03%]
PDX1突变食蟹猴胰腺发育不全及m6A甲基化改变
Wen-Hui Zhang,Jiong-Han Zhuang,Yun-Yi Guo et al.
Wen-Hui Zhang et al.
As an essential transcriptional activator, PDX1 plays a crucial role in pancreatic development and β-cell function. Mutations in the PDX1 gene may lead to type 4 maturity-onset diabetes of the young (MODY4) and neonatal diabetes mellitus. ...
IDH2 and GLUD1 depletion arrests embryonic development through an H4K20me3 epigenetic barrier in porcine parthenogenetic embryos [0.03%]
IDH2和GLUD1缺失通过猪孤雌胚胎发育过程中的H4K20me3表观遗传屏障而阻滞胚胎发育
Cheng-Lin Zhan,Qin-Yue Lu,Song-Hee Lee et al.
Cheng-Lin Zhan et al.
Isocitrate dehydrogenase 2 (IDH2) and glutamate dehydrogenase 1 (GLUD1) are key enzymes involved in the production of α-ketoglutarate (α-KG), a metabolite central to the tricarboxylic acid cycle and glutamine metabolism. In this study, we...
Jin Miao,Huanhuan Zhu,Junni Wang et al.
Jin Miao et al.
Acute kidney injury (AKI) and chronic kidney disease (CKD) are significant public health issues associated with a long-term increase in mortality risk, resulting from various etiologies including renal ischemia, sepsis, drug toxicity, and d...