Yong-Gang Yao,Yong-Tang Zheng
Yong-Gang Yao
Animal models of Alzheimer's disease: Current strategies and new directions [0.03%]
阿尔茨海默病的动物模型：当前策略及新的发展方向
Qing Wang,Bai-Ting Zhu,Peng Lei
Qing Wang
Animal models constructed using pathogenic factors have significantly advanced drug development for Alzheimer's disease (AD). These predominantly transgenic models, mainly in mice, replicate pathological phenotypes through gene mutations as...
Whole-genome methylation reveals tissue-specific differences in non-CG methylation in bovine [0.03%]
全基因组甲基化揭示了牛非CpG甲基化的组织特异性差异
Jing Wang,Wen Yuan,Fang Liu et al.
Jing Wang et al.
DNA methylation at non-CG dinucleotides (mCH, H=A, C, T) widely occurs and plays an important role in specific cell types, including pluripotent, neural, and germ cells. However, the functions and regulatory mechanisms of mCH, particularly ...
Investigating the molecular mechanisms of oocyte maturation and ovulation in Nile tilapia: A focus on the steroidogenic enzyme Cyp17a2 [0.03%]
尼罗罗非鱼卵母细胞成熟和排卵分子机理的研究——重点考察类固醇合成酶Cyp17a2的功能
Lan-Ying Yang,You Wu,Xue-Feng Zhang et al.
Lan-Ying Yang et al.
Previous research has highlighted the significant role of progestins and glucocorticoids in fish oocyte maturation and ovulation. To clarify the molecular mechanisms underlying these processes, comprehensive investigations were conducted us...
Investigation of sex determination in starry flounder ( Platichthys stellatus) reveals sex chromosome evolution in Pleuronectiformes and identifies a sex-specific marker [0.03%]
探究星斑扁甲鱼（Platichthys stellatus）的性别决定方式揭示了Pleuronectiformes中的性染色体进化并确定了一个性别特异性标记
Wei-Jing Li,Yu-Man Zhang,Shuo Li et al.
Wei-Jing Li et al.
The identification of sex chromosomes is fundamental for exploring the mechanism and evolution of sex determination. Platichthys stellatus, a species exhibiting clear sexual dimorphism and homomorphic chromosome pairs, has received limited ...
New insights and investigation: Morphomolecular notes on the infraciliature, taxonomy, and systematics of pleurostomatid ciliates (Protozoa, Ciliophora), with establishment of a new suborder, two new genera, and three new species [0.03%]
新见解与调查：腹毛目纤毛虫(原生动物门，纤毛门)的亚体形-分子特征、分类及系统发育，并建立一个新次序、两个新属及三个新种
Gong-Ao-Te Zhang,Teng-Yue Zhang,Yong Chi et al.
Gong-Ao-Te Zhang et al.
Pleurostomatid ciliates, as a highly diverse and widely distributed unicellular eukaryote group, play a crucial role in the cycling of nutrients and energy in microbial food webs. However, research on pleurostomatids remains insufficient, r...
Repressor elements provide insights into tissue development and phenotypes in pigs [0.03%]
抑制子元件提供了猪组织发育和表型的见解
Yue-Dong Zhang,Chao Guo,Hang Liu et al.
Yue-Dong Zhang et al.
Repressor elements significantly influence economically relevant phenotypes in pigs; however, their precise roles and characteristics are inadequately understood. In the present study, we employed H3K27me3 profiling, assay for transposase-a...
Female zebra finches are more vulnerable to social isolation stress than males: Involvement of the nonapeptide system [0.03%]
雌性斑马雀比雄性更易受到社会隔离压力的影响：非肽激素系统的参与
Limin Wang,Zhuang Hao,Lirong Zuo et al.
Limin Wang et al.
In group-living animals, chronic juvenile social isolation stress (SIS) can profoundly affect behavior and neuroendocrine regulation. However, its impact on social behavior in avian species, particularly regarding sex-specific neural circui...
Peptide Cy RL-QN15 accelerates hair regeneration in diabetic mice by binding to the Frizzled-7 receptor [0.03%]
肽Cy RL-QN15通过结合原肌球蛋白受体激酶加速糖尿病小鼠毛发再生
Yu-Tong Wu,Ze-Qiong Ru,Ying Peng et al.
Yu-Tong Wu et al.
Individuals with diabetes frequently face serious challenges, including delayed wound healing and increased risk of infection. Notably, the regeneration of hair follicles plays a crucial role in accelerating diabetic skin damage repair, red...
Integrative cross-species transcriptome analysis reveals earlier occurrence of myelopoiesis in pre-circulation primates compared to mice [0.03%]
整合跨物种转录组分析揭示了胎盘前阶段灵长类动物比小鼠更早出现髓系造血现象
Junjie Du,Zongcheng Li,Yandong Gong et al.
Junjie Du et al.
Hematopoiesis originates in the yolk sac, which forms prior to the establishment of blood circulation and exhibits distinct developmental processes between primates and mice. Despite increasing appreciation of yolk sac hematopoiesis for its...