Han Zhang,Ming-Tian Pan,Yu-Xuan Li et al.
Han Zhang et al.
Tauopathies represent a class of neurodegenerative diseases (NDs), including Alzheimer's disease (AD), progressive supranuclear palsy (PSP), Pick's disease (PiD), and corticobasal degeneration (CBD), defined by intracellular accumulation of...
Amphibians as a source of bioactive antioxidant peptides: Emerging insights and therapeutic potential [0.03%]
两栖动物作为活性抗氧化肽来源的新兴见解及其治疗潜力
Yi-Yun Zhu,Li-Mei Zhao,Xin-Yi Jia et al.
Yi-Yun Zhu et al.
Oxidative stress arises from disruption of the balance between reactive oxygen species (ROS) production and detoxification and constitutes a fundamental driver of diverse pathological diseases. Skin photoaging is a well-recognized example, ...
Integrating a cationic backbone with a hydrophobic core: A structure-function strategy for designing self-assembling antimicrobial peptides with enhanced activity [0.03%]
阳离子骨架与疏水核心的整合：一种用于设计具有增强活性的抗菌肽的结构功能策略
James Mwangi,Dawit Adisu Tadese,Yi Wang et al.
James Mwangi et al.
Effective countermeasures against multidrug-resistant nosocomial pathogens, such as carbapenem-resistant Klebsiella pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA), require the development of innovative antimicrobial strat...
Ultra-short cyclic peptide Cy RL-QN15 acts as a TLR4 antagonist to expedite oral ulcer healing [0.03%]
超短环形肽Cy RL-QN15作为TLR4拮抗剂促进口腔溃疡愈合
Ze-Qiong Ru,Yu-Tong Wu,Chong-Yu Yang et al.
Ze-Qiong Ru et al.
Oral ulcers (OUs) are among the most common lesions of the oral mucosa, typically associated with pain and burning sensations, and remain clinically challenging due to the scarcity of effective treatment options. Cy RL-QN15, a novel ultra-s...
Coordinated inhibition of M1 macrophage polarization by FIT2-mediated lipid droplet biosynthesis and FABP5 [0.03%]
FIT2介导的脂滴生物合成和FABP5协调抑制M1型巨噬细胞极化
Yi-Han Liu,Bei Li,Yuan-Xing Zhang et al.
Yi-Han Liu et al.
Lipid droplets (LDs) serve as dynamic organelles central to host immune response and bacterial infection resistance by recruiting multiple proteins and peptides with established antiviral and antibacterial properties. Although macrophage po...
Acute hypoxia suppresses blood glycolysis in saker falcons ( Falco cherrug) via NR3C1-mediated repression of HK1: Evidence from hematological and epigenomic profiling [0.03%]
急性缺氧通过NR3C1介导的HK1抑制抑制猎隼（Falco cherrug）血糖分解：来自血液学和表观基因组谱分析的证据
Wei Wu,Xiao-Hang Zhang,Fei-Fei Du et al.
Wei Wu et al.
Ongoing climate change is driving high-altitude bird species to occupy even higher elevations, yet physiological and regulatory responses enabling these transitions remain poorly understood. This study investigated acute hypoxic responses i...
LEAP2 triggers retromer-mediated membrane trafficking of MOSPD2 to promote chemotaxis in teleost monocytes/macrophages [0.03%]
LEAP2通过诱导retromer介导的MOSPD2膜转运促进辐鳍鱼类单核细胞/巨噬细胞趋化性
Ting-Fang Zhu,Zi-Yue Zhao,Chen-Jie Fei et al.
Ting-Fang Zhu et al.
Liver-expressed antimicrobial peptide 2 (LEAP2) is a key regulator of innate immune defense in teleosts, yet the molecular basis of its chemotactic function remains largely unidentified. Boleophthalmus pectinirostris MOSPD2 ( BpMOSPD2) was ...
Interleukin-22 functions to alleviate hypoxia-induced intestinal inflammation by modulating pro- and anti-inflammatory factors in Pelteobagrus fulvidraco [0.03%]
黄颡鱼白ensis白细胞介素-22通过调节促炎和抗炎因子缓解缺氧诱导的肠道炎症功能
Heng-Qing Huan,Yu-Bing Ding,Zi-Ang Qian et al.
Heng-Qing Huan et al.
Intestinal inflammation is a common challenge in intensive aquaculture, yet its pathogenesis remains unclear. While interleukin 22 (IL-22) is recognized as a critical regulator of cellular homeostasis during inflammation in higher vertebrat...
CK1α in Sertoli cells is essential for testicular development and spermatogenesis in mice [0.03%]
CatSper钾通道调节亚单位1α在支持细胞中对小鼠睾丸发育和精子发生是必不可少的
Hong-Zhou Guo,Ming-Yue Wang,Di Zhang et al.
Hong-Zhou Guo et al.
Male infertility constitutes a major global public health concern, with the underlying etiology remaining unidentified in nearly half of the diagnosed cases. Protein kinase CK1α (CK1α) functions as a pivotal regulator of cell cycle progre...
CircSHOC2 regulates steroid hormone synthesis in ovarian granulosa cells through the mir-130b-5p/ASH1L pathway [0.03%]
环状RNA CircSHOC2通过mir-130b-5p/ASH1L途径调节卵巢颗粒细胞类固醇激素合成
Lu-Tong Zhang,Teng Zhang,Xiang-Rong Song et al.
Lu-Tong Zhang et al.
Estrus represents a critical phase in the porcine reproductive cycle and relies on functional ovarian development and coordinated steroidogenesis. Granulosa cells (GCs) mediate these processes by secreting estradiol (E 2) and progesterone (...