Apoptosis of Mdm2-deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles [0.03%]
Mdm2缺陷型骨细胞的凋亡通过TRPM8富集的凋亡小体促进成骨作用
Xin Liu,Huiwen Zheng,Aochen Wang et al.
Xin Liu et al.
During homeostasis, osteocyte apoptosis is typically associated with bone loss through enhanced osteoclast recruitment and bone resorption. However, whether apoptotic osteocytes also regulate bone formation remains elusive. Here we report t...
DMP1-Cre expressing cells mediate the gain in bone mass and strength, but not the increase in bone remodeling, induced by ligands of the parathyroid hormone receptor [0.03%]
甲状旁腺激素受体配体诱导的骨量和强度增加而不是骨重建增高的机制与DMP1-Cre表达细胞有关
Nisreen Akel,Sasidhar Uppuganti,Jeff D Thostenson et al.
Nisreen Akel et al.
Signaling downstream of the receptor of parathyroid hormone (PTH1R) exerts two major skeletal effects: increases bone remodeling and, when stimulated intermittently, induces bone anabolism. Osteocytes express the PTH1R and are critical for ...
Fgfr3-Wnt signaling crosstalk is involved in maintaining cranial suture integrity [0.03%]
FGFR3-Wnt信号通路的相互作用参与颅缝完整性维持
Rachel Pereur,Yvan Marc,Yuliya Lim et al.
Rachel Pereur et al.
Cranial suture formation is a dynamic process that requires precise cellular and molecular coordination to regulate bone growth and maintain suture homeostasis. The Fibroblast Growth Factor Receptor 3 (FGFR3) signaling pathway is among the ...
Osteocyte-specific gasdermin D deletion accelerates osteoarthritis via promoting subchondral inflammation and remodeling [0.03%]
特异性删除骨细胞中的Gasdermin D会通过促进软骨下的炎症和重塑从而加速骨关节炎发展
Yuki Ogawa,Taku Ebata,Taiki Tokuhiro et al.
Yuki Ogawa et al.
Subchondral bone remodeling in the early stages of osteoarthritis (OA) is characterized by elevated bone turnover and is closely associated with osteocyte function within the subchondral bone. However, beyond the canonical role of gasdermin...
Osteocalcin-dependent and -independent metabolic dysregulation in a mouse model of Osteogenesis imperfecta [0.03%]
基于成骨不全症小鼠模型的骨钙素依赖性和非依赖性代谢失调
Josephine T Tauer,Frank Rauch,Mathieu Ferron et al.
Josephine T Tauer et al.
Osteogenesis imperfecta (OI) is a rare bone fragility disorder. Previously, in a severe OI mouse model (Col1a1Jrt/+), a sex- and age-dependent metabolic phenotype was observed, correlating with elevated levels of the bone-derived hormone os...
Bispecific antibody against sclerostin and DKK1 improves bone health and reduces bone marrow adipose tissue accumulation in experimental chronic kidney disease [0.03%]
靶向骨硬化素和DKK1的双特异性抗体可改善实验性慢性肾脏病小鼠的骨骼健康并减少骨髓脂肪蓄积
Worachet Promruk,Soher N Jayash,Chartinun Chutoe et al.
Worachet Promruk et al.
Chronic kidney disease (CKD) leads to bone loss and bone marrow adipose tissue (BMAT) accumulation. Sclerostin and dickkopf-1 (DKK1) are two inhibitors of Wnt signalling, which suppress bone formation, promote bone marrow adipogenesis, and ...
Taiyuan Huang,Jianxiong Shu,Zhaoran Wu et al.
Taiyuan Huang et al.
Osteoarthritis (OA) is a highly heterogeneous disease that exhibits distinct clinical manifestations and pathological mechanisms in different joints, patients, and even at different disease stages for the same patient. Genetic and pathophys...
Inhibition of AXL receptor tyrosine kinase increases osteoblast function and bone mass [0.03%]
AXL受体酪氨酸激酶抑制可增加成骨细胞功能和骨量
Mubashir Ahmad,Christoph Kölbl,Irfana Jan et al.
Mubashir Ahmad et al.
Osteoporosis, a prevalent age-related disease, is characterized by impaired bone formation and an increased risk of fractures. Current anabolic treatments primarily rely on biologics, which are costly and require inconvenient administration...
Clec3b+ extraskeletal cells regulate fracture healing and heterotopic ossification [0.03%]
Clec3b阳性骨外细胞调控骨折愈合和异位骨化
Ezgi Aydin,Jacob A Moore,Mark Bubnovich et al.
Ezgi Aydin et al.
Bone healing is orchestrated by multiple cell populations, including those that normally do not produce bone but acquire osteoprogenitor capabilities following injury. Muscle-resident fibroadipogenic progenitors (FAPs) and superficial perio...
Coral-inspired immunoreprogramming scaffold reverses the "immune-freeze" microenvironment to promote bone regeneration in steroid-induced osteonecrosis of the femoral head [0.03%]
珊瑚启发的免疫重编程支架逆转糖皮质激素诱导股骨头坏死组织中“免疫休克”的微环境以促进骨再生
Yue Luo,Qianhao Li,Changjun Chen et al.
Yue Luo et al.
The core pathological mechanism of steroid-induced osteonecrosis of the femoral head (SONFH) is an "immune freeze" microenvironment-where corticosteroids continuously drive macrophages toward a pro-inflammatory M1 phenotype, inhibiting the ...