Tissue and extracellular matrix remodeling of the subchondral bone during osteoarthritis of knee joints as revealed by spatial mass spectrometry imaging [0.03%]
空间质谱成像揭示的膝关节骨关节炎下软骨骨组织和细胞外基质重塑
Charles A Schurman,Joanna Bons,Jonathon J Woo et al.
Charles A Schurman et al.
Osteoarthritis (OA) is a degenerative skeletal condition marked by the loss of articular cartilage and changes to subchondral bone homeostasis. Treatments for OA beyond full joint replacement are lacking primarily due to gaps in molecular k...
Neutralizing hepatic apolipoprotein E enhances aged bone fracture healing [0.03%]
中和肝脏载脂蛋白E可增强老年骨折愈合
Mingjian Huang,Abhinav Reddy Balu,Kristin Happ Molitoris et al.
Mingjian Huang et al.
Advanced age impairs bone fracture healing; the underlying mechanism of this phenomenon remains unknown. We determined that apolipoprotein E (ApoE) increases with age and causes poor fracture healing. After deletion of hepatic ApoE expressi...
PTH induced osteoblast Slit3 to decrease aberrant sensory innervation in degenerated vertebral endplates to relieve low back pain in mice [0.03%]
PTH通过诱导骨细胞Slit3表达减少退变椎间盘终板异常感觉神经侵入从而缓解小鼠慢性下腰痛
Weixin Zhang,Arryn D Otte,Zhuolun Wang et al.
Weixin Zhang et al.
During aging, the spine undergoes degenerative changes, particularly with vertebral endplate bone expansion and sclerosis, that are associated with nonspecific low back pain. We report that parathyroid hormone (PTH) treatment reduced verteb...
Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization [0.03%]
thrombospondin 1和2调节间充质干细胞命运及基质组织化
Madysen K Hunter,Sneha Korlakunta,Neda Vishlaghi et al.
Madysen K Hunter et al.
Thrombospondin 1 and 2 (TSP1 and TSP2) are critical regulators of extracellular matrix (ECM) interactions, influencing cell differentiation and tissue repair. Recent discoveries from our laboratory and others highlight the importance of alt...
Bone sialoprotein: a multifunctional regulator of bone remodelling and tumour progression [0.03%]
骨基质蛋白骨囊素：一种骨重塑和肿瘤进展的多功能调节因子
Valentina Kottmann,Philipp Drees,Erol Gercek et al.
Valentina Kottmann et al.
Bone sialoprotein (BSP) is a major non-collagenous protein of the bone extracellular matrix and an important regulator of bone formation and resorption. BSP is produced by bone cells and chondrocytes and present in the bone matrix, cells, d...
The role of the lymphatic system in musculoskeletal system health and disease: research progress and future directions [0.03%]
淋巴系统在肌肉骨骼系统健康和疾病中的作用：研究进展与未来方向
Yan Luo,Jie Song,Shengyuan Zheng et al.
Yan Luo et al.
The lymphatic system is widely distributed in skeletal muscles, joints, and skeletal tissues and plays a key role in maintaining immune homeostasis, regulating inflammatory responses, and tissue repair. In recent years, an increasing number...
Neutrophil-initiated nociceptive ingrowth orchestrates inflammation resolution to potentiate bone regeneration [0.03%]
中性粒细胞介导的痛觉生长原发促进炎症消退以增强骨再生
Xuanyu Qi,Guangzheng Yang,Zeqian Xu et al.
Xuanyu Qi et al.
Nociceptive pain is a cardinal feature of traumatic and inflammatory bone diseases. However, whether and how nociceptors actively regulate the immune response during bone regeneration remains unclear. Here, we found that neutrophil-triggere...
APEX1, a transcriptional hub for endochondral ossification and fracture repair [0.03%]
APEX1：软骨内骨化和骨折修复的转录调控中枢
José Valdés-Fernández,Miguel Echanove-González de Anleo,Juan Antonio Romero-Torrecilla et al.
José Valdés-Fernández et al.
After injury, bone tissue initiates a reparative response to restore its structure and function. The failure to initiate or delay this response could result in fracture nonunion. The molecular mechanisms underlying the occurrence of fractur...
TGF-β/BMP signaling in skeletal biology: molecular mechanisms, regulatory networks, and therapeutic implications in development, regeneration, and disease [0.03%]
转化生长因子-β/骨形态发生蛋白信号通路在骨骼生物学中的分子机制、调控网络及在发育、再生和疾病治疗中的应用前景
Junguang Liao,Taofen Wu,Qi Zhang et al.
Junguang Liao et al.
The transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP) signaling pathways are pivotal regulators of cellular processes, playing indispensable roles in embryogenesis, postnatal development, and tissue homeostasis. Th...
Progress on Omega-3 fatty acids for the comprehensive and targeted treatment of spinal cord injury [0.03%]
欧米伽-3脂肪酸全面治疗脊髓损伤的进展
Zhongze Yuan,Lusen Shi,Xiao-Na Tao et al.
Zhongze Yuan et al.
Traumatic spinal cord injury (SCI) is a debilitating condition characterized by the impairment of neural circuits, leading to the loss of motor and sensory functions and accompanied by severe complications. Substantial research has reported...