Aging microenvironment in osteoarthritis focusing on early-stage alterations and targeted therapies [0.03%]
聚焦早期变化和靶向治疗的骨关节炎老化微环境研究进展
Yifan Dang,Yuhang Liu,Bingjun Zhang et al.
Yifan Dang et al.
Osteoarthritis (OA) is one of the most common degenerative and age-related diseases in joints, which affects 654 million people worldwide. Current therapies could not fundamentally reverse the pathologic process of OA due to the complex pat...
Injured bone-triggered osteokines secretion promotes diabetic wound healing [0.03%]
损伤骨组织释放的炎症因子促进糖尿病难愈性创面修复
Tong Shen,Kai Dai,Shuang Zhang et al.
Tong Shen et al.
The treatment of severe diabetic foot remains a clinical challenge. While it is established that bone can exert systemic effects through the secretion of osteokines on other organs, whether this endocrine function can be harnessed to promot...
Author Correction: Synovial fibroblast derived small extracellular vesicles miRNA15-29148 promotes articular chondrocyte apoptosis in rheumatoid arthritis [0.03%]
作者更正：滑膜成纤维细胞衍生的小细胞外囊泡miRNA15-29148促进类风湿关节炎软骨细胞凋亡
Zhenyu Zhang,Lulu Liu,Huibo Ti et al.
Zhenyu Zhang et al.
Published Erratum
Bone research. 2025 Sep 30;13(1):82. DOI:10.1038/s41413-025-00468-3 2025
Unraveling the mechanisms of bone diseases: targeting dendritic cells in osteoimmunology for internal homeostasis balance [0.03%]
解开骨病的机制：通过免疫骨骼学靶向树突细胞以维持体内平衡
Yanqi Chen,Siyuan Wang,Xiaoyu Chen et al.
Yanqi Chen et al.
Bone repair and regeneration is a complex spatiotemporal process recruiting a variety of cell types, which need to precisely mediated for effective healing post-damage. The concept of osteoimmunology emphasizes the extensive and intricate c...
Nuclear FGF2 orchestrates phase separation-mediated rDNA chromatin architecture to control BMSCs cell fate [0.03%]
核FGF2通过介导相分离调控rDNA染色质高级结构以控制BMSCs细胞命运决定
Hengguo Zhang,Zifei Wang,Zhenqing Liu et al.
Hengguo Zhang et al.
Ribosomal RNA (rRNA) synthesis is intricately tied to cellular growth and proliferation. Basic fibroblast growth factor (FGF2), a pivotal factor for bone marrow mesenchymal stem cells (BMSCs), can stimulates rRNA transcription, though the u...
Mechanism of Piezo1 regulating chondrocyte mitochondrial function and promoting fracture healing through β-catenin/LARS2 signaling pathway [0.03%]
Piezo1通过β-catenin/LARS2信号通路调节软骨细胞线粒体功能促进骨折愈合的机制研究
Tao Zhang,Hongzhi Lv,Siming Jia et al.
Tao Zhang et al.
Piezo1, a key mechanosensor in bone homeostasis, plays a crucial role in fracture healing. However, the mechanisms through which Piezo1 regulates chondrocytes and affects endochondral ossification remain poorly understood. This study aimed ...
Xinning Mao,Ke Lv,Weihui Qi et al.
Xinning Mao et al.
Sarcopenia, a progressive and systemic skeletal muscle disorder marked by the accelerated deterioration of both muscle function and mass, is highly prevalent among the elderly population, significantly contributing to an elevated risk of ad...
The impact of mitochondrial dysfunction on osteoarthritis cartilage: current insights and emerging mitochondria-targeted therapies [0.03%]
线粒体功能障碍对骨关节炎软骨的影响：当前研究进展和新兴的线粒体靶向疗法
Siyuan Tan,Yujun Sun,Shixun Li et al.
Siyuan Tan et al.
Osteoarthritis (OA) is a degenerative joint disease associated with age, prominently marked by articular cartilage degradation. In OA cartilage, the pathological manifestations show elevated chondrocyte hypertrophy and apoptosis. The mitoch...
The role of the unfolded protein response pathway in bone homeostasis and potential therapeutic target in cancer-associated bone disease [0.03%]
未折叠蛋白反应通路在骨稳态中的作用及其作为癌症相关性骨病的治疗靶点的潜在作用
Molly E Muehlebach,Sarah A Holstein
Molly E Muehlebach
The unfolded protein response pathway is an evolutionarily conserved cytoprotective signaling cascade, essential for cell function and survival. Unfolded protein response signaling is tightly integrated with bone cell differentiation and fu...
Association between osteoporosis and rotator cuff tears: evidence from causal inference and colocalization analyses [0.03%]
骨质疏松与肩袖撕裂的关联性：来自因果推论和共定位分析的证据
Yibin Liu,Rong Zhao,Zhiyu Huang et al.
Yibin Liu et al.
Osteoporosis is a known risk factor for rotator cuff tears (RCTs), but the causal correlation and underlying mechanisms remain unclear. This study aims to evaluate the impact of osteoporosis on RCT risk and investigate their genetic associa...