Youthfulness of marrow Adipoq+ cells maintained by Cbfβ facilitates stem cell-based bone repair [0.03%]
Cbfβ维持的髓质Adipoq+细胞的干性使其能够促进基于干细胞的骨修复
Tiannan Huang,Shali Wu,Wei Qian et al.
Tiannan Huang et al.
Exhaustion of skeletal stem and progenitor cells (SSPCs) drives age-related delays in fracture repair, yet the upstream regulators of SSPC maintenance are unclear. We identify that core-binding factor β (Cbfβ) in bone marrow Adipoq+ cells...
Human growth plates house resting zone sub-populations with features of quiescent stem cells [0.03%]
生长板中休止区亚群具有静息干细胞的特征
Mahtab Avijgan,Ana R López-Pérez,Leire Alonso Galicia et al.
Mahtab Avijgan et al.
Maintaining postnatal bone growth is crucial for humans to reach their final height. To determine transcriptional networks coordinating this process, we applied spatially resolved transcriptomics to growth plate biopsies obtained from healt...
Inflammation driven by NF-ĸB compromises bone formation by inducing the differentiation of osteoblasts into atypical inflammatory osteocyte-like cells [0.03%]
NF-κB驱动的炎症通过诱导成骨细胞分化为非典型炎性成骨细胞样细胞而损害骨形成
Gaurav Swarnkar,Md Fahim Ahmad,Marwa Zeyad et al.
Gaurav Swarnkar et al.
Inflammation causes bone loss by dysregulating the differentiation and functions of osteoclasts, osteoblasts, and osteocytes. This process can be modeled by the expression of constitutively activated IKK2 (IKK2ca), a strategy that we levera...
IGSF10 regulates osteogenesis and osteoclastogenesis via a noncanonical EGFR-STAT1 signaling axis to promote skeletal regeneration [0.03%]
IGSF10通过非经典的EGFR-STAT1信号轴调节成骨和破骨以促进骨骼再生
Jin Wen,Yuwei Deng,Ruixue Jiang et al.
Jin Wen et al.
Bone remodeling requires precise coordination between osteoblast-mediated bone formation and osteoclast-driven resorption. However, directly targetable and therapeutically actionable mediators that can coordinately modulate both processes d...
Apoptosis of Mdm2-deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles [0.03%]
Mdm2缺陷型骨细胞的凋亡通过TRPM8富集的凋亡小体促进成骨作用
Xin Liu,Huiwen Zheng,Aochen Wang et al.
Xin Liu et al.
During homeostasis, osteocyte apoptosis is typically associated with bone loss through enhanced osteoclast recruitment and bone resorption. However, whether apoptotic osteocytes also regulate bone formation remains elusive. Here we report t...
DMP1-Cre expressing cells mediate the gain in bone mass and strength, but not the increase in bone remodeling, induced by ligands of the parathyroid hormone receptor [0.03%]
甲状旁腺激素受体配体诱导的骨量和强度增加而不是骨重建增高的机制与DMP1-Cre表达细胞有关
Nisreen Akel,Sasidhar Uppuganti,Jeff D Thostenson et al.
Nisreen Akel et al.
Signaling downstream of the receptor of parathyroid hormone (PTH1R) exerts two major skeletal effects: increases bone remodeling and, when stimulated intermittently, induces bone anabolism. Osteocytes express the PTH1R and are critical for ...
Fgfr3-Wnt signaling crosstalk is involved in maintaining cranial suture integrity [0.03%]
FGFR3-Wnt信号通路的相互作用参与颅缝完整性维持
Rachel Pereur,Yvan Marc,Yuliya Lim et al.
Rachel Pereur et al.
Cranial suture formation is a dynamic process that requires precise cellular and molecular coordination to regulate bone growth and maintain suture homeostasis. The Fibroblast Growth Factor Receptor 3 (FGFR3) signaling pathway is among the ...
Osteocyte-specific gasdermin D deletion accelerates osteoarthritis via promoting subchondral inflammation and remodeling [0.03%]
特异性删除骨细胞中的Gasdermin D会通过促进软骨下的炎症和重塑从而加速骨关节炎发展
Yuki Ogawa,Taku Ebata,Taiki Tokuhiro et al.
Yuki Ogawa et al.
Subchondral bone remodeling in the early stages of osteoarthritis (OA) is characterized by elevated bone turnover and is closely associated with osteocyte function within the subchondral bone. However, beyond the canonical role of gasdermin...
Osteocalcin-dependent and -independent metabolic dysregulation in a mouse model of Osteogenesis imperfecta [0.03%]
基于成骨不全症小鼠模型的骨钙素依赖性和非依赖性代谢失调
Josephine T Tauer,Frank Rauch,Mathieu Ferron et al.
Josephine T Tauer et al.
Osteogenesis imperfecta (OI) is a rare bone fragility disorder. Previously, in a severe OI mouse model (Col1a1Jrt/+), a sex- and age-dependent metabolic phenotype was observed, correlating with elevated levels of the bone-derived hormone os...
Bispecific antibody against sclerostin and DKK1 improves bone health and reduces bone marrow adipose tissue accumulation in experimental chronic kidney disease [0.03%]
靶向骨硬化素和DKK1的双特异性抗体可改善实验性慢性肾脏病小鼠的骨骼健康并减少骨髓脂肪蓄积
Worachet Promruk,Soher N Jayash,Chartinun Chutoe et al.
Worachet Promruk et al.
Chronic kidney disease (CKD) leads to bone loss and bone marrow adipose tissue (BMAT) accumulation. Sclerostin and dickkopf-1 (DKK1) are two inhibitors of Wnt signalling, which suppress bone formation, promote bone marrow adipogenesis, and ...