Unveiling roles of non-coding RNAs in cancer through advanced technologies [0.03%]
通过先进技术揭示非编码RNA在癌症中的作用
Runhao Wang,Leng Han
Runhao Wang
Non-coding RNAs (ncRNAs) have emerged as key regulators in tumorigenesis. In this perspective, we briefly review the significance of ncRNA in cancer biology and highlight recent technological advancements in characterization of ncRNA in can...
Perspectives on integrating artificial intelligence and single-cell omics for cellular plasticity research [0.03%]
人工智能与单细胞组学在细胞可塑性研究中融合的机遇与挑战展望
Ahmed Ghobashi,Qin Ma
Ahmed Ghobashi
Cellular plasticity enables cells to dynamically adapt to environmental changes by altering their phenotype. This plasticity plays a crucial role in tissue repair and regeneration and contributes to pathological processes such as cancer met...
Computational Systems Biology Approaches to Cellular Aging - Integrating Network Maps and Dynamical Models [0.03%]
计算系统生物学方法研究细胞衰老——整合网络图谱和动力学模型
Hetian Su,Nan Hao
Hetian Su
Cellular aging is a multifaceted, complex process. Many genes and factors have been identified that regulate cellular aging. However, how these genes and factors interact with one another and how these interactions drive the aging processes...
Comprehensive cross cancer analyses reveal mutational signature cancer specificity [0.03%]
综合跨癌症分析揭示了突变特征的癌症特异性
Rui Xin,Limin Jiang,Hui Yu et al.
Rui Xin et al.
Mutational signatures refer to distinct patterns of DNA mutations that occur in a specific context or under certain conditions. It is a powerful tool to describe cancer etiology. We conducted a study to show cancer heterogeneity and cancer ...
Bioinformatics and biomedical informatics with ChatGPT: Year one review [0.03%]
基于ChatGPT的生物信息学和生物医学 informatics 年度回顾
Jinge Wang,Zien Cheng,Qiuming Yao et al.
Jinge Wang et al.
The year 2023 marked a significant surge in the exploration of applying large language model chatbots, notably Chat Generative Pre-trained Transformer (ChatGPT), across various disciplines. We surveyed the application of ChatGPT in bioinfor...
A comprehensive evaluation of large language models in mining gene relations and pathway knowledge [0.03%]
全面评估大型语言模型在挖掘基因关系和途径知识方面的表现
Muhammad Azam,Yibo Chen,Micheal Olaolu Arowolo et al.
Muhammad Azam et al.
Understanding complex biological pathways, including gene-gene interactions and gene regulatory networks, is critical for exploring disease mechanisms and drug development. Manual literature curation of biological pathways cannot keep up wi...
WIPER: Weighted in-Path Edge Ranking for biomolecular association networks [0.03%]
基于生物分子关联网络的加权路径内边排名算法(WIPER)
Zongliang Yue,Thanh Nguyen,Eric Zhang et al.
Zongliang Yue et al.
Background: In network biology researchers generate biomolecular networks with candidate genes or proteins experimentally-derived from high-throughput data and known biomolecular associations. Current bioinformatics resea...
Deciphering the protein-DNA code of bacterial winged helix-turn-helix transcription factors [0.03%]
解读细菌翼旋螺旋-转角-螺旋型转录因子的蛋白质-DNA密码
Adam P Joyce,James J Havranek
Adam P Joyce
Background: Sequence-specific binding by transcription factors (TFs) plays a significant role in the selection and regulation of target genes. At the protein:DNA interface, amino acid side-chains construct a diverse physi...
Dong Xu
Dong Xu
Evelyn Shue,Li Liu,Bingxin Li et al.
Evelyn Shue et al.
The impressive conversational and programming abilities of ChatGPT make it an attractive tool for facilitating the education of bioinformatics data analysis for beginners. In this study, we proposed an iterative model to fine-tune instructi...