Psychological health mediates the association between diet and upper gastrointestinal cancer: a cross-sectional analysis from a large-scale population-based screening project [0.03%]
饮食对上消化道肿瘤的影响存在心理健康的中介作用——一项大规模人群筛查的横断面分析
Yueying Zhang,Shanrui Ma,Xinqing Li et al.
Yueying Zhang et al.
Objective: Upper gastrointestinal (UGI) cancer, including esophageal and gastric cancers, poses a significant health burden. While unhealthy dietary patterns are a recognized risk factor for UGI cancer, the complex interp...
Microbiota-host interaction in colorectal cancer: emerging computational technology, multi-omics integration, and mechanisms [0.03%]
结直肠癌中微生物组与宿主的相互作用：新兴计算技术、多组学整合及机制研究
Yinghong Lu,Jun Yu
Yinghong Lu
Colorectal cancer (CRC) remains a major global health burden with the gut microbiome emerging as a critical contributor to tumor initiation and progression. Advances in high-throughput sequencing have deepened our understanding of host-micr...
Sihan Li,Fashun Li,Jiasheng Tu et al.
Sihan Li et al.
Postbiotics, considered the functional successors of live probiotics, retain most of probiotics' structural and/or bioactive properties, and are key mediators of probiotic-environment interactions. Beyond influencing tumor proliferation, me...
Single-cell and spatial transcriptome analyses reveal tumor immunometabolism in lymph node metastasis of lung cancer [0.03%]
单细胞和空间转录组分析揭示肺癌淋巴结转移的肿瘤免疫代谢特征
Yang Zhang,Wangyang Zhu,Chaoqiang Deng et al.
Yang Zhang et al.
Objective: Progressive metabolic adaptation of tumor cells enables a thriving tumor microenvironment in which immune cells have diminished killing ability. However, whether and how this adaptation plays an active role in ...
Expert consensus on the detection and clinical application of tumor mutational burden [0.03%]
肿瘤突变负荷的检测与临床应用专家共识
Zhenying Guo,Chunwei Xu,Shirong Zhang et al.
Zhenying Guo et al.
As an emerging biomarker, tumor mutational burden (TMB) has attracted increasing attention from clinicians in predicting the efficacy of tumor immunotherapy. Currently, TMB is detected primarily by whole-exome sequencing or targeted panel s...
Applying microfluidic technology to interpret the tumor immune microenvironment and cancer immunotherapy [0.03%]
微流控技术解读肿瘤免疫微环境及癌症免疫治疗研究进展
Xuhong Chen,Dongxian Tan,Shuaiting Liu et al.
Xuhong Chen et al.
In the past decade, cancer immunotherapy has emerged as a transformative treatment modality for diverse malignancies. Although impressive clinical efficacy has been demonstrated in some cancer patients, most patients respond poorly to immun...
VDAC1 protein derived from extracellular vesicles promotes paclitaxel resistance in gastric cancer through autophagy and mitophagy [0.03%]
胃癌细胞来源的外泌体VDAC1蛋白通过自噬和线粒体自噬促进紫杉醇耐药性
Yanna Bi,Sisi Wei,Zhe Zhang et al.
Yanna Bi et al.
Objective: Paclitaxel (PTX), a conventional second-line therapeutic agent for advanced gastric cancer (GC), exhibits compromised clinical efficacy due to acquired chemoresistance in patients, the molecular mechanisms of w...
Coordinated DNA methyltransferase 3A and methyltransferase-like 7A activity reprograms the tumor microenvironment through discoidin domain receptor 1 signaling [0.03%]
DNA甲基转移酶3A和类似甲基转移酶7A的协同活性通过盘状结构域受体1信号对肿瘤微环境进行重新编程
Zhengyang Bai,Dan Yang,Jiayi Li et al.
Zhengyang Bai et al.
Objective: Breast cancer is the most common malignancy in women and is characterized by a high recurrence rate that severely impacts patient survival. Regulatory T cells (Tregs) in the tumor microenvironment (TME) promote...
Antitumor effects of STING agonists on nervous system tumors via tumor-intrinsic STING-STAT1-mediated HMGN2 expression [0.03%]
STING激动剂通过肿瘤内在的STING-STAT1-HMGN2轴对神经系统肿瘤产生抗肿瘤作用
Zijian Lv,Tiance Wang,Runjia Fan et al.
Zijian Lv et al.
Objective: Clinical use of stimulator of interferon genes (STING) agonists has challenges due to poor responsiveness and variable efficacy. Therefore, identifying tumor types that are sensitive to these agents and clarify...
CD4+ T cells in cancer: dual roles, exhaustion, and therapeutic breakthroughs [0.03%]
CD4+T细胞在肿瘤免疫中的双重角色、耗竭及治疗突破
Yangyang Zhang,Jingli Xu,Siwei Pan et al.
Yangyang Zhang et al.
In recent years the crucial role of CD4+ T cells in tumor immunomodulation has garnered increasing recognition. While conventional cancer immunotherapy research has predominantly focused on the cytotoxic function of CD8+ T cells, emerging e...