Mitochondrial uncoupling inhibits serine catabolism via FTO activation in metastatic breast cancer [0.03%]
线粒体解偶联通过激活FTO抑制乳腺癌转移中的丝氨酸分解代谢
Xin Jin,Albert M Li,Man Zhao et al.
Xin Jin et al.
Objective: The mitochondrial serine catabolic pathway (MSCP) supports tumor proliferation and metastasis, yet no therapies target the MSCP. Because cancer cells rely on the MSCP when respiration is suppressed, we hypothes...
Click chemistry-driven tumor theranostics: recent advances, challenges, and future perspectives [0.03%]
点击化学驱动的肿瘤诊疗研究：最近进展、挑战和未来前景
Dayong Hou,Xiangpeng Li,Niyuan Zhang et al.
Dayong Hou et al.
Tumor theranostics, which integrates accurate diagnosis and precise therapy, has emerged as a pivotal approach in modern oncology for improving treatment efficacy and reducing off-target toxicity. Click chemistry, which is characterized by ...
From concept to clinic: emerging paradigms and novel insights into liquid biopsy [0.03%]
从概念到临床：液体活检的新范式和新见解
Wenjie Guo,Yang Liu,Haiying Dong et al.
Wenjie Guo et al.
BEX2 influences the MCL1-Hedgehog signaling axis to regulate the potential of stemness characterization in colorectal cancer [0.03%]
BEX2通过影响MCL1- Hedgehog信号轴调节结直肠癌干细胞特性潜能
Yucheng Qian,Jingsun Wei,Yuan Bian et al.
Yucheng Qian et al.
Objective: Colorectal cancer (CRC) progression is driven by cancer stem cells (CSCs) that evade treatment through dynamic phenotype modulation. Our previous research identified BEX2 as a significant regulator of CRC malig...
Targeting tumor-infiltrating regulatory T cells based on immunometabolism [0.03%]
基于免疫代谢针对肿瘤浸润调节性T细胞的靶向治疗
Na Li,Dexue Tian
Na Li
The immune checkpoint blockade (ICB) approach in cancer therapy involves the disruption of immune checkpoint inhibitory signals on tumor-specific CD8+ T cells, thereby reinstating the immune activity of CD8+ T cells and yielding therapeutic...
Expansion of IL-2-independent tumor-infiltrating lymphocytes through a feeder-free process: a preclinical study for solid tumors [0.03%]
一种无喂养细胞的IL-2非依赖型肿瘤浸润淋巴细胞体外扩增方法及其抗实体瘤效应功能的初步研究
Ying Zhang,Sicheng Du,Rongrui Liu et al.
Ying Zhang et al.
Objective: Conventional tumor-infiltrating lymphocyte (TIL) therapy for solid tumors relies on high-dose interleukin-2 (IL-2) during expansion and post-infusion, and promotes T-cell exhaustion and toxicity. Herein, we dev...
Cancer-immunity cycle-based molecular subtypes in breast cancer predict the response to immune checkpoint inhibitors [0.03%]
基于癌症-免疫循环的乳腺癌分子亚型可预测免疫检查点抑制剂的治疗反应
Di Shao,Tianjian Yu,Yi Xiao et al.
Di Shao et al.
Objective: The cancer-immunity cycle (CIC) outlines key steps of anti-tumor immunity from antigen release to T cell effector function. A comprehensive evaluation of the CIC in patients with breast cancer is lacking, which...
Identification of immune reconstitution and hematopoiesis restoration by scRNA-seq in bone marrow of multiple myeloma patients treated with high-dose melphalan following auto-HSCT [0.03%]
高剂量化疗后自体HSCT治疗多发性骨髓瘤患者免疫重建和造血恢复的单细胞转录组分析
Qian Li,Yaling Wang,Hongfeng Yuan et al.
Qian Li et al.
First-line immunotherapy for advanced HER2-negative gastric cancer: differences between Asian and non-Asian patients [0.03%]
一线免疫治疗晚期HER2阴性胃癌：亚洲和非亚洲患者的区别
Chuanhua Zhao,Sisi Ye,Meng Chen et al.
Chuanhua Zhao et al.
Emerging evidence suggests that the efficacy of immunotherapy in patients with advanced HER2-negative gastric cancer differs between Asian and non-Asian populations. This review examines potential factors contributing to these disparities, ...
Exosomal EPHA2 transfers metastatic potential by stabilizing TGF-βRI and activating the TGF-β/SMAD3 signaling pathway in breast cancer [0.03%]
乳腺癌中 EphA2 标记的外泌体通过稳定 TGF-βⅠ型受体和激活 TGF-β/SMAD3 信号通路转移侵袭性表型
Liming Liu,Yichu Zhang,Xiaoxue Li et al.
Liming Liu et al.
Objective: Intratumoral heterogeneity refers to the presence of distinct subpopulations of cancer cells within a single tumor, which exhibits variations in phenotypic traits, such as proliferation rate, drug sensitivity, ...