How the gut microbiome affects the immunotherapy response in hepatocellular carcinoma [0.03%]
肝细胞癌免疫治疗反应的肠道微生物影响机制研究
Mengrui Wu,Yating Zhang,Jun Yu
Mengrui Wu
Hepatocellular carcinoma (HCC) remains a major global health challenge with limited long-term survival despite advances in surgical, locoregional, and systemic treatments. Although immune checkpoint blockade (ICB) has reshaped HCC therapy, ...
Jie Wang,Hao Pan,Xuan Wang et al.
Jie Wang et al.
Circadian rhythms orchestrate 24-h oscillations in gene expression to govern diverse physiologic functions. Mounting evidence suggests that circadian disruption, resulting from aberrant light exposure, shift work, or genetic mutations in co...
Drug resistance to antibody-drug conjugates: mechanisms, challenges, and perspectives [0.03%]
抗体偶联药物耐药性：机制、挑战和展望
Yajing Liu,Yuwei Liu,Tingting Wu et al.
Yajing Liu et al.
Antibody-drug conjugates (ADCs) have emerged as a transformative class of cancer therapeutics by combining the target precision of antibodies with the potent cytotoxic effects of chemotherapeutic agents. This unique approach aims to enhance...
Lactate drives immune resistance via a pharmaceutically reversible H3K18la-KIF20A-c-Myc-PD-L1 axis in hepatocellular carcinoma [0.03%]
乳酸通过可药用逆转的组蛋白H3K18la-KIF20A-c-Myc-PD-L1轴驱动肝癌免疫抵抗作用
Shujia Chen,Lili Zhao,Ping Han et al.
Shujia Chen et al.
Objective: Resistance to immunotherapy, driven by the immunosuppressive tumor microenvironment, remains a major clinical challenge in hepatocellular carcinoma (HCC). Although metabolic reprogramming is a known culprit, th...
Metabolic engineering of SLC38A2 reprograms glutamine utilization and enhances CAR-macrophage antitumor function in solid tumors [0.03%]
代谢工程改造SLC38A2蛋白可重新编程谷氨酰胺利用并增强实体肿瘤中的CAR-巨噬细胞抗肿瘤功能
Mingzhu Liu,Qingxi Chen,Luoling Zhang et al.
Mingzhu Liu et al.
Objective: This study was aimed at investigating metabolic dysregulation in tumor-associated macrophages (TAMs) in breast cancer and developing a metabolically enhanced chimeric antigen receptor macrophage (CAR-M) strateg...
Surgery-centered integrated strategies for personalized hepatocellular carcinoma care [0.03%]
以手术为中心的肝细胞癌精准治疗综合策略
Yuhan Cui,Zuchao Du,Jiahao Xu et al.
Yuhan Cui et al.
Hepatocellular carcinoma (HCC) remains a major global health burden characterized by late-stage diagnosis and high postoperative recurrence rates. This review presents a surgery-centered precision management framework integrating 3 synergis...
Animal models and pathogenesis of gastric cancer: from premalignant conditions-to-metastasis [0.03%]
动物模型和胃癌的发生机制：从癌前状态到转移
Yumeng Pan,Licong Zhao,Jingyuan Fang
Yumeng Pan
Gastric cancer (GC) remains one of the most prevalent malignancies of the gastrointestinal tract worldwide, ranking fifth in incidence and continuing to be a leading cause of cancer-related mortality. Elucidating the mechanisms underlying G...
Virtual histology imaging of lymph nodes via dynamic full-field optical coherence tomography and deep learning to differentiate metastasis [0.03%]
基于动态全场光学相干层析成像和深度学习的虚拟组织学成像区分淋巴结转移
Shuwei Zhang,Houpu Yang,Yiyin Zhang et al.
Shuwei Zhang et al.
Objective: The current pathological diagnosis of lymph node metastasis is time-consuming, labor-intensive, and dependent on sectioning of paraffin blocks. Herein, in a prospective cohort of patients with breast cancer, we...
Observational Study
Cancer biology & medicine. 2026 Mar 28;23(3):418-429. DOI:10.20892/j.issn.2095-3941.2025.0747 2026
Enhancing FIT-based colorectal cancer screening through risk prediction: a comparative evaluation of 17 models in a large Chinese cohort [0.03%]
基于风险预测改进FIT结直肠癌筛查：在中国大型队列中比较17种模型性能
Le Wang,Weimiao Wu,Bin Liu et al.
Le Wang et al.
Global epidemiology of ovarian cancer: patterns, trends, and risk factors [0.03%]
全球卵巢癌流行病学：特征、趋势和危险因素
Ruyuan Li,Anqi Zhao,Meicen Liu et al.
Ruyuan Li et al.
Ovarian cancer was the eighth most frequently diagnosed cancer among women in 2022. The global age-standardized incidence rate of ovarian cancer decreased from 7.22/100,000 to 6.71/100,000 from 1990 to 2021. However, incidence trends varied...