Advances in TROP2-targeted antibody-drug conjugates for breast cancer therapy: into the new era [0.03%]
乳腺癌治疗的TROP2靶向抗体药物偶联物新进展：开启新时代
Kuikui Jiang,Shusen Wang
Kuikui Jiang
Jianbin Li,Zefei Jiang
Jianbin Li
Breast cancer is the most common malignant tumor among women globally and poses a major public health challenge due to limitations in traditional diagnostic and treatment processes, such as subjective interpretation biases and inefficient m...
Protocol and statistical designs in classic clinical research-toripalimab series trial analysis [0.03%]
经典临床研究的方案和统计设计——托里帕利单抗系列试验分析
Yingjian He,Li Bian,Zefei Jiang
Yingjian He
Multimodal artificial intelligence predicts PIK3CA mutation in breast cancer from digital pathology and clinical data: a multicenter study [0.03%]
多模态人工智能从数字病理学和临床数据中预测乳腺癌的PIK3CA突变：一项多中心研究
Jiaxian Miao,Qi Liu,Jianing Zhao et al.
Jiaxian Miao et al.
Objective: Accurate detection of PIK3CA mutations is essential for guiding PI3K-targeted therapies in breast cancer, yet sequencing is not universally accessible, and single-modality prediction models have limited perform...
Multicenter Study
Cancer biology & medicine. 2026 Apr 7;23(3):430-450. DOI:10.20892/j.issn.2095-3941.2025.0771 2026
Non-coding RNA delivery via lipid nanoparticles: a novel strategy for cancer immunotherapy [0.03%]
脂质纳米颗粒递送非编码RNA：癌症免疫治疗的新策略
Yufei Sheng,Lulu Yang,Boyang Wang et al.
Yufei Sheng et al.
Non-coding RNAs (ncRNAs) regulate antitumor immunity but clinical use is hindered by instability, poor specificity, and immunogenic risk. Lipid nanoparticles (LNPs) offer a promising delivery solution due to biocompatibility, a modifiable s...
How the gut microbiome affects the immunotherapy response in hepatocellular carcinoma [0.03%]
肝细胞癌免疫治疗反应的肠道微生物影响机制研究
Mengrui Wu,Yating Zhang,Jun Yu
Mengrui Wu
Hepatocellular carcinoma (HCC) remains a major global health challenge with limited long-term survival despite advances in surgical, locoregional, and systemic treatments. Although immune checkpoint blockade (ICB) has reshaped HCC therapy, ...
Jie Wang,Hao Pan,Xuan Wang et al.
Jie Wang et al.
Circadian rhythms orchestrate 24-h oscillations in gene expression to govern diverse physiologic functions. Mounting evidence suggests that circadian disruption, resulting from aberrant light exposure, shift work, or genetic mutations in co...
Drug resistance to antibody-drug conjugates: mechanisms, challenges, and perspectives [0.03%]
抗体偶联药物耐药性：机制、挑战和展望
Yajing Liu,Yuwei Liu,Tingting Wu et al.
Yajing Liu et al.
Antibody-drug conjugates (ADCs) have emerged as a transformative class of cancer therapeutics by combining the target precision of antibodies with the potent cytotoxic effects of chemotherapeutic agents. This unique approach aims to enhance...
Lactate drives immune resistance via a pharmaceutically reversible H3K18la-KIF20A-c-Myc-PD-L1 axis in hepatocellular carcinoma [0.03%]
乳酸通过可药用逆转的组蛋白H3K18la-KIF20A-c-Myc-PD-L1轴驱动肝癌免疫抵抗作用
Shujia Chen,Lili Zhao,Ping Han et al.
Shujia Chen et al.
Objective: Resistance to immunotherapy, driven by the immunosuppressive tumor microenvironment, remains a major clinical challenge in hepatocellular carcinoma (HCC). Although metabolic reprogramming is a known culprit, th...