A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer [0.03%]
基于基础模型的CT影像组学标志物在胃癌三级淋巴结构非侵入性评估及预测治疗效益中的应用
Xianchun Gao,Zhe Li,Jun Yu et al.
Xianchun Gao et al.
Poor prognosis outcome tumors, bacteria-infected tumors and nanodrugs: current evidence and hypotheses towards a paradigm change for treatment [0.03%]
不良预后肿瘤、细菌感染的肿瘤和纳米药物：治疗模式变革的当前证据及假设
Henk J Busscher,David W Grainger,JinPu Yu et al.
Henk J Busscher et al.
New therapies and supportive care have converted several cancer types into chronic conditions. Yet, some tumors exhibit features reproducibly correlated with poor prognosis outcome (PPO-tumors). Bacteria in a tumor environment can inactivat...
Pyroptosis in cancer: a dual regulator of tumor cell fate and immune activation [0.03%]
细胞焦亡在癌症中的作用：肿瘤细胞命运和免疫激活的双重调节因素
Yuewen Zhang,Mengshi Luo,Zhiqi Liao et al.
Yuewen Zhang et al.
Pyroptosis is a form of programmed cell death (PCD) that triggers inflammation. Pyroptosis is activated by specific inflammasomes and caspases, leading to the cleavage of gasdermin protein families, especially gasdermin D (GSDMD) and gasder...
Metabolic regulation of tumor-associated macrophage function and immunotherapy in cancer [0.03%]
代谢调节肿瘤相关巨噬细胞功能和癌症免疫疗法
Mingyue Zhao,Rui Chen,Ping Gao
Mingyue Zhao
Tumor-associated macrophages (TAMs), essential components of the tumor immune microenvironment (TIME), undergo metabolic reprogramming as part of functional adaptation. Tumor cells modulate TAMs through multiple mechanisms, including metabo...
Machine learning-based clinical decision support tool for advanced ESCC in the immunotherapy era: a multi-center study [0.03%]
基于机器学习的临床决策支持工具在免疫治疗时代的晚期食管鳞癌中的应用：一项多中心研究
Hui Bai,Xiaofeng Wang,Qifeng Wang et al.
Hui Bai et al.
Objective: We aimed to develop clinical decision support tools for patients with treatment-naïve advanced esophageal squamous cell carcinoma (ESCC). Meth...
The role of radiomics in predicting the response to neoadjuvant chemotherapy for breast cancer [0.03%]
影像组学在预测乳腺癌新辅助化疗反应中的作用研究
Yilin Chen,Ye Qin,Man Yang et al.
Yilin Chen et al.
Breast cancer exhibits profound biological and spatial heterogeneity, which contributes to variable responses to neoadjuvant chemotherapy (NAC) and challenges precision treatment planning. Radiomics, an emerging discipline that converts sta...
Balancing global standards and regional nuances in breast cancer care: the role of guidelines, clinical research, precision medicine, and artificial intelligence in advancing quality of care for patients worldwide [0.03%]
全球标准与区域差异在乳腺癌诊治中的平衡：指南、临床研究、精准医疗及人工智能在提升全球患者治疗效果中的作用
Michael Gnant
Michael Gnant
Precision immunotherapy for breast cancer: from biomarkers to clinical practice [0.03%]
乳腺癌精准免疫治疗：从生物标志物到临床实践
Jie Mei,Kai Yang,Xinkang Zhang et al.
Jie Mei et al.
Integrative multi-omic analysis identified ERBB2 mutations and senescence-driven immune suppression as dual therapeutic targets in LAR triple-negative breast cancer [0.03%]
整合多组学分析识别出ERBB2突变和衰老驱动的免疫抑制是LAR型三阴性乳腺癌的双重治疗靶点
Yaxin Zhao,Han Wang,Ying Wang et al.
Yaxin Zhao et al.
Objective: The luminal androgen receptor (LAR) subtype of triple-negative breast cancer (TNBC) differentiation displays low proliferation yet strong metastatic potential and a poor chemotherapy response. This study aimed ...