Tumor-resident bacteria in gastrointestinal cancers: from regulatory mechanisms to clinical implications [0.03%]
胃肠道肿瘤中的固有细菌：从调控机制到临床意义
Ying Zhang,Bingyu Tan,Qianying Zhou et al.
Ying Zhang et al.
The human microbiome is increasingly recognized as a key contributor to the tumor microenvironment (TME). Advances in sequencing technologies have revealed the pivotal role of intratumoral microbiota in the development of gastrointestinal c...
From diagnostic marker-to-therapeutic modality: emerging paradigms in tumor biomineralization [0.03%]
从诊断标志物到治疗手段：肿瘤生物矿化的新范式
Fan Liu,Qiqi Cao,Qinglan Chen et al.
Fan Liu et al.
Biomineralization is a highly regulated, multi-scale biological process that is well-characterized in physiologic contexts but remains poorly understood in pathologic settings. Tumor-associated calcification frequently occurs in clinical pr...
Unravelling the role of PANoptosis in diseases: from emerging molecular mechanisms-to-therapeutic implications [0.03%]
解码PANoptosis在疾病中的作用：从新兴分子机制到治疗意义
Yi Zhu,Shengming Ou,Xuer Ye et al.
Yi Zhu et al.
PANoptosis represents a distinct form of programmed cell death (PCD) that is characterized by the integration of key features from apoptosis, pyroptosis, and necroptosis but cannot be fully explained by any single cell death pathway. A key ...
The m7G RNA modification in gastrointestinal cancers: mechanisms and therapeutic potential [0.03%]
胃肠道癌症中的m7G RNA修饰：机制和治疗潜力
Rui Li,Xiaoqing Lu,Zhiyu Guan et al.
Rui Li et al.
The N7-methylguanosine (m7G) modification, an epigenetic transcriptional regulatory mechanism, plays a crucial role in the development of gastrointestinal malignant tumors. This modification, mediated by enzyme complexes such as methyltrans...
A foundation model-enhanced CT radiomics signature for the noninvasive assessment of tertiary lymphoid structures and prediction of therapy benefit in gastric cancer [0.03%]
基于基础模型的CT影像组学标志物在胃癌三级淋巴结构非侵入性评估及预测治疗效益中的应用
Xianchun Gao,Zhe Li,Jun Yu et al.
Xianchun Gao et al.
Poor prognosis outcome tumors, bacteria-infected tumors and nanodrugs: current evidence and hypotheses towards a paradigm change for treatment [0.03%]
不良预后肿瘤、细菌感染的肿瘤和纳米药物：治疗模式变革的当前证据及假设
Henk J Busscher,David W Grainger,JinPu Yu et al.
Henk J Busscher et al.
New therapies and supportive care have converted several cancer types into chronic conditions. Yet, some tumors exhibit features reproducibly correlated with poor prognosis outcome (PPO-tumors). Bacteria in a tumor environment can inactivat...
Pyroptosis in cancer: a dual regulator of tumor cell fate and immune activation [0.03%]
细胞焦亡在癌症中的作用：肿瘤细胞命运和免疫激活的双重调节因素
Yuewen Zhang,Mengshi Luo,Zhiqi Liao et al.
Yuewen Zhang et al.
Pyroptosis is a form of programmed cell death (PCD) that triggers inflammation. Pyroptosis is activated by specific inflammasomes and caspases, leading to the cleavage of gasdermin protein families, especially gasdermin D (GSDMD) and gasder...
Metabolic regulation of tumor-associated macrophage function and immunotherapy in cancer [0.03%]
代谢调节肿瘤相关巨噬细胞功能和癌症免疫疗法
Mingyue Zhao,Rui Chen,Ping Gao
Mingyue Zhao
Tumor-associated macrophages (TAMs), essential components of the tumor immune microenvironment (TIME), undergo metabolic reprogramming as part of functional adaptation. Tumor cells modulate TAMs through multiple mechanisms, including metabo...
Machine learning-based clinical decision support tool for advanced ESCC in the immunotherapy era: a multi-center study [0.03%]
基于机器学习的临床决策支持工具在免疫治疗时代的晚期食管鳞癌中的应用：一项多中心研究
Hui Bai,Xiaofeng Wang,Qifeng Wang et al.
Hui Bai et al.
Objective: We aimed to develop clinical decision support tools for patients with treatment-naïve advanced esophageal squamous cell carcinoma (ESCC). Meth...