Gut microbiota and pancreatic cancer: tumorigenesis, progression, and clinical applications [0.03%]
肠道菌群与胰腺癌：肿瘤发生、进展及临床应用
Chuxiong Cheng,Jingsong Wang,Jin Xie et al.
Chuxiong Cheng et al.
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies of the digestive system, with a 5-year survival rate of only 13%, which is largely due to late-stage diagnosis and limited therapeutic options. Emerging evid...
Tumor microenvironment-driven natural killer cell diversity: mechanisms and therapeutic opportunities [0.03%]
肿瘤微环境驱动的天然杀伤细胞多样性：机制和治疗机会
Yue Duan,Mingzhen Zhou,Xingxian Guo et al.
Yue Duan et al.
Natural killer (NK) cells are key effector cells involved in tumor immune surveillance, yet their function within the tumor microenvironment (TME) exhibits considerable complexity and plasticity that cannot be adequately explained by the cl...
Dietary nitrate drives gastritis by modulating gastric microbiota and metabolites [0.03%]
膳食硝酸盐通过调控胃部微生物组和代谢物驱动胃炎产生
Lanping Jiang,Tianhui Li,Jiayu Wu et al.
Lanping Jiang et al.
Objective: Dietary nitrate has been increasingly recognized as a potential carcinogen associated with gastritis. In this study the mechanistic role of a high-nitrate diet (NaD) in driving gastritis was elucidated with a f...
Evolution in single-cell proteomics drives new frontiers in cancer biology and precision medicine [0.03%]
单细胞蛋白质组学的进化推动了癌症生物学和精准医学的新进展
Yi Liu,Yingdong Du,Ran Su et al.
Yi Liu et al.
The inherent heterogeneity of cancer leads to varied responses to treatment and underscores the need for the development of precision medicine. Single-cell proteomics is crucial for deciphering intra- and inter-tumor heterogeneity. Mass cyt...
Design principles of nanomaterials for cancer immunotherapy: a mechanistic framework across the cancer immunity cycle [0.03%]
癌症免疫周期的纳米材料设计原则：机制框架
Yating Bai,Zhihao Lan,Nana Feng et al.
Yating Bai et al.
Cancer immunotherapy has revolutionized oncology by harnessing the immune system to eliminate malignant cells, yet its efficacy remains constrained by insufficient antigen presentation, limited T cell infiltration, and the immunosuppressive...
Opportunities and challenges of immunotherapy for patients with resectable and potentially resectable stage III non-small cell lung cancer [0.03%]
可切除和潜在可切除的III期非小细胞肺癌患者的免疫治疗机遇与挑战
Yuzhen Cui,Jingdong Xu,Junxu Wen et al.
Yuzhen Cui et al.
The integration of immune checkpoint inhibitors has transformed the therapeutic landscape for patients with resectable and potentially resectable stage III non-small cell lung cancer, providing unprecedented opportunities for curative treat...
Tumor-resident bacteria in gastrointestinal cancers: from regulatory mechanisms to clinical implications [0.03%]
胃肠道肿瘤中的固有细菌：从调控机制到临床意义
Ying Zhang,Bingyu Tan,Qianying Zhou et al.
Ying Zhang et al.
The human microbiome is increasingly recognized as a key contributor to the tumor microenvironment (TME). Advances in sequencing technologies have revealed the pivotal role of intratumoral microbiota in the development of gastrointestinal c...
From diagnostic marker-to-therapeutic modality: emerging paradigms in tumor biomineralization [0.03%]
从诊断标志物到治疗手段：肿瘤生物矿化的新范式
Fan Liu,Qiqi Cao,Qinglan Chen et al.
Fan Liu et al.
Biomineralization is a highly regulated, multi-scale biological process that is well-characterized in physiologic contexts but remains poorly understood in pathologic settings. Tumor-associated calcification frequently occurs in clinical pr...
Unravelling the role of PANoptosis in diseases: from emerging molecular mechanisms-to-therapeutic implications [0.03%]
解码PANoptosis在疾病中的作用：从新兴分子机制到治疗意义
Yi Zhu,Shengming Ou,Xuer Ye et al.
Yi Zhu et al.
PANoptosis represents a distinct form of programmed cell death (PCD) that is characterized by the integration of key features from apoptosis, pyroptosis, and necroptosis but cannot be fully explained by any single cell death pathway. A key ...
The m7G RNA modification in gastrointestinal cancers: mechanisms and therapeutic potential [0.03%]
胃肠道癌症中的m7G RNA修饰：机制和治疗潜力
Rui Li,Xiaoqing Lu,Zhiyu Guan et al.
Rui Li et al.
The N7-methylguanosine (m7G) modification, an epigenetic transcriptional regulatory mechanism, plays a crucial role in the development of gastrointestinal malignant tumors. This modification, mediated by enzyme complexes such as methyltrans...