Microbial reprogramming of immunogenic cell death: a new paradigm in tumor immunotherapy [0.03%]
微生物介导的免疫性细胞死亡重编程：肿瘤免疫治疗的新范式
Yilin Li,Huiyue Zhang,Yun Feng et al.
Yilin Li et al.
Immunogenic cell death (ICD), a special form of cell death, transforms "cold" tumors into "hot" tumors by fulfilling the following three key conditions: antigenicity; adjuvanticity; and a suitable tumor microenvironment (TME). Tumor cells r...
Xiaofei Jiao,Yiyang Shen,Yixuan Tang et al.
Xiaofei Jiao et al.
T cell activity is fundamental to effective immunotherapies and sustained tumor control. Recent studies have demonstrated that the therapeutic potential of T cells is notably affected by DNA damage dynamics. Notably, DNA damage within T cel...
Ferumoxytol triggers cancer ferroptosis via an NF-κB-driven IRONKILL mechanism [0.03%]
富马氧托尔通过NF-κB驱动的IRONKILL机制触发癌症铁依赖性细胞死亡（ Ferroptosis）
Tao Luo,Meng Li,Shijie Zhang et al.
Tao Luo et al.
HBx-mediated GPT2 suppression promotes liver cancer development by downregulating ADH1A [0.03%]
Hbx通过下调Adh1a抑制Gpt2促进肝癌发生发展
Hongjuan You,Xing Wang,Ruyu Liu et al.
Hongjuan You et al.
Objective: Hepatitis B virus (HBV) is the primary driver of liver cancer (LC), a malignancy characterized by extensive metabolic reprogramming. However, the specific mechanisms linking viral oncoproteins to metabolic dysr...
CAMK2D isoform 15 facilitates gefitinib resistance via AKT phosphorylation in lung adenocarcinoma [0.03%]
CAMK2D的第15种亚型通过AKT磷酸化促进肺腺癌细胞对吉非替尼产生耐药性
Lingmei Li,Danyang Ren,Yutian Wang et al.
Lingmei Li et al.
Objective: Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is a major challenge in the treatment of lung adenocarcinoma (LUAD). Our previous study demonstrated that EGFR sign...
VAMP2/SNAP25 promotes the aggressive progression of head and neck cancer by regulating the fate of multivesicular bodies [0.03%]
VAMP2/SNAP25通过调节多囊体的命运促进头颈部肿瘤的侵袭性发展
Suwen Bai,Hexing Sun,Rong Liu et al.
Suwen Bai et al.
Objective: Tumor-secreted exosomes are essential in driving tumor progression by releasing multivesicular bodies (MVBs), which are endosome organelles containing intraluminal vesicles (ILVs), as exosomes. However, the mec...
Induction immunochemotherapy followed by definitive radiotherapy in patients with limited-stage small cell lung cancer: a multicenter study [0.03%]
小细胞肺癌局限性期患者诱导免疫化疗后进行根治性放疗的多中心研究
Junxu Wen,Qian Wang,Xinrui Yu et al.
Junxu Wen et al.
Lenvatinib triggers an EGR1-ZNF768-SLC7A11 adaptive response to limit ferroptosis-mediated therapeutic efficacy in hepatocellular carcinoma [0.03%]
仑伐替尼通过触发EGR1-ZNF768-SLC7A11适应性反应限制铁死亡介导的治疗效果以促进肝细胞癌耐药形成
Jialei Hua,Shuya Zhao,Changsen Bai et al.
Jialei Hua et al.
Objective: Adaptive therapeutic tolerance frequently limits first-line lenvatinib efficacy in hepatocellular carcinoma (HCC). This study explored the C2H2-type zinc finger (ZNF) protein family (the largest class of transc...
Probiotics in colorectal cancer: mechanisms, biomarkers, and adjunct strategies [0.03%]
益生菌在结直肠癌中的作用：机制、生物标志物和辅助策略
Zihe Xu,Lan Mu,Hao Su et al.
Zihe Xu et al.
Colorectal cancer (CRC) is among the most common malignant tumors and remains a leading cause of cancer-related mortality worldwide. The gut microbiota and metabolites, which are modulated by host genetics and environmental exposures, have ...
Bifidobacterium animalis suppresses melanoma progression and activates anti-tumor immunity by inhibiting YAP1 expression in CD8+ T cells [0.03%]
动物双歧杆菌通过抑制CD8+T细胞中YAP1表达来抑制黑色素瘤的进展并激活抗肿瘤免疫反应
Chengyi Li,Xuehua Zhang,Yichen Yang et al.
Chengyi Li et al.
Objective: The probiotic, Bifidobacterium animalis, (B. animalis) is known to provide health benefits in humans. This study investigated the role of B. animalis in suppressing malignant melanoma progression and modulating...