Exosomal B7H3 drives immunosuppression and serves as a biomarker for PD-1 blockage response in head and neck squamous cell carcinoma [0.03%]
外泌体B7H3在头颈鳞癌中驱动免疫抑制并可作为PD-1阻断治疗应答的标志物
Wen Wang,Chulong Xie,Juncong Luo et al.
Wen Wang et al.
Objective: Patients with head and neck squamous cell carcinoma (HNSCC) display a remarkably low response rate to immune checkpoint inhibitor (ICI) therapy. Currently, there is an urgent unmet need for reliable non-invasiv...
Erratum to PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells [0.03%]
PGK1偶联的HSP90通过稳定GSK3β的表达调节乳腺癌干细胞干性的修正案
Wei Tang,Yu Wu,Xin Qi et al.
Wei Tang et al.
Less is more: patients with cervical cancer benefit from de-escalated chemotherapy plus immuno-targeted therapies [0.03%]
更少即是更多：化疗减量化联合免疫治疗可造福宫颈癌患者
Bohao Zheng,Dian Fan,Shengtao Zhou
Bohao Zheng
Unveiling molecular incomplete response (mIR) via ultra-deep NGS: a novel concept contrasting pathologic complete response (pCR) in occult lymph node micrometastases of non-small cell lung cancer [0.03%]
通过超深度测序揭示分子残留病（mIR）：与隐藏淋巴结微转移的非小细胞肺癌病理完全缓解(pCR)相对的新概念
Meng Lu,Ran Zhang,Haidi Xu et al.
Meng Lu et al.
Thermal ablation versus loop electrosurgical excision procedure and cold knife conization for cervical intraepithelial neoplasia: efficacy and HPV clearance in a 5-year cohort of Chinese women [0.03%]
射频消融与LEEP及冷刀锥切治疗宫颈上皮内瘤变的疗效及人乳头状瘤病毒转阴的五年随访研究
Meiwen Yuan,Xuelian Zhao,Shangying Hu et al.
Meiwen Yuan et al.
Objective: To evaluate the 5-year efficacy of thermal ablation (TA) for cervical intraepithelial neoplasia (CIN) and high-risk HPV (hrHPV) clearance in Chinese women. ...
Toward the precision use of Chinese PARP inhibitors in ovarian cancer: clinical progress, resistance mechanisms, and future perspectives [0.03%]
精准使用中国卵巢癌PARP抑制剂：临床进展、耐药机制及未来展望
Jing Yu,Maochen Li,Yuhan Zhu et al.
Jing Yu et al.
Antibiotics and probiotics differentially shape immunotherapy outcomes in non-small cell lung cancer [0.03%]
抗生素和益生元通过不同机制影响非小细胞肺癌免疫疗法的疗效
Shuling Ma,Zijun Zhai,Rui Ding et al.
Shuling Ma et al.
Comprehensive microbiome profiling reveals mucosal microbiome heterogeneity in patients with left- and right-sided colorectal neoplasia [0.03%]
全面的微生物组谱分析揭示了左、右结直肠肿瘤患者黏膜微生物组的异质性
Sunny H Wong,Thomas N Y Kwong,Ru Zhang et al.
Sunny H Wong et al.
Objective: Left- and right-sided colorectal cancer (CRC) exhibit distinct molecular and clinicopathologic features. However, little is known about the spatial heterogeneity of microbial signatures. In this study the profi...
Efficacy and safety of first-line osimertinib in Chinese patients with EGFR-mutated advanced non-small cell lung cancer: a prospective, multicenter, non-interventional study (FLOURISH) [0.03%]
一线奥希替尼治疗中国EGFR突变阳性晚期非小细胞肺癌患者的有效性和安全性：一项前瞻性、多中心、非干预性研究（FLOURISH）
Lisha Shen,Dongqing Lv,Ke-Jing Tang et al.
Lisha Shen et al.
Objective: Osimertinib has demonstrated superior efficacy as a first-line treatment for epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) in clinical trials. This study was aimed at provid...