Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective [0.03%]
衰老和与年龄相关疾病的代谢和代谢组学：多尺度视角
Ziyi Wang,Hongying Zhu,Wei Xiong
Ziyi Wang
The pursuit of healthy aging has long rendered aging and senescence captivating. Age-related ailments, such as cardiovascular diseases, diabetes, and neurodegenerative disorders, pose significant threats to individuals. Recent studies have ...
Cardiomyocyte-specific long noncoding RNA Trdn-as induces mitochondrial calcium overload by promoting the m6A modification of calsequestrin 2 in diabetic cardiomyopathy [0.03%]
长链非编码RNA Trdn-as通过促进肌浆网Ca²⁺结合蛋白calsequestrin 2的m６A修饰诱导糖尿病心肌病线粒体钙超载
Xiaohan Li,Ling Liu,Han Lou et al.
Xiaohan Li et al.
Diabetic cardiomyopathy (DCM) is a medical condition characterized by cardiac remodeling and dysfunction in individuals with diabetes mellitus. Sarcoplasmic reticulum (SR) and mitochondrial Ca2+ overload in cardiomyocytes have been recogniz...
Non small cell lung cancer with SMARCA4 deficiency harboring rare EGFR mutations exhibited significant tumor response when treated with afatinib: a case report [0.03%]
报告一起携带罕见EGFR突变的SMARCA4缺陷型非小细胞肺癌接受阿法替尼治疗后显著获益的病例
Xiaotong Qiu,Liangkun You,Chongwei Wang et al.
Xiaotong Qiu et al.
SMARCA4-deficient non small cell lung cancer (SMARCA4-dNSCLC) has recently garnered increasing attention due to its high malignancy and poor prognosis. The literature suggests that in non small cell lung cancer (NSCLC), the loss of SMARCA4 ...
Canonical and noncanonical NOTCH signaling in the nongenetic resistance of cancer: distinct and concerted control [0.03%]
癌症非遗传耐药中的 notch 信号传导的规范和非常规作用：不同与联合调控
Xianzhe Huang,Wenwei Chen,Yanyan Wang et al.
Xianzhe Huang et al.
Therapeutic resistance in cancer is responsible for numerous cancer deaths in clinical practice. While target mutations are well recognized as the basis of genetic resistance to targeted therapy, nontarget mutation resistance (or nongenetic...
Gallstones, cholecystectomy, and cancer risk: an observational and Mendelian randomization study [0.03%]
胆囊结石、胆囊切除与癌症风险关系的观察及孟德尔随机化研究
Yuanyue Zhu,Linhui Shen,Yanan Huo et al.
Yuanyue Zhu et al.
This study aimed to comprehensively examine the association of gallstones, cholecystectomy, and cancer risk. Multivariable logistic regressions were performed to estimate the observational associations of gallstones and cholecystectomy with...
Does the outcome of acupuncture differ according to the location of sham needling points in acupuncture trials for migraine? A systematic review and network meta-analysis [0.03%]
假针刺点的位置会影响针刺治疗偏头痛的疗效吗？系统评价和网络 Meta 分析
Boram Lee,Chan-Young Kwon,Hye Won Lee et al.
Boram Lee et al.
Various acupuncture clinical trials have been conducted on migraine; however, the conclusions remain controversial especially when acupuncture was compared with sham acupuncture. Sham acupuncture is sometimes performed at the same acupunctu...
Erratum to: Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis [0.03%]
整合型全基因组分析鉴定汉族人IgA肾病的易感位点及相关细胞类型之余论
Ming Li,Xingjie Hao,Dianchun Shi et al.
Ming Li et al.
Published Erratum
Frontiers of medicine. 2024 Dec;18(6):1119. DOI:10.1007/s11684-024-1121-3 2024
Preclinical and clinical studies on Qin-Zhu-Liang-Xue decoction: insights from network pharmacology and implications for atopic dermatitis treatment [0.03%]
秦艽珍珠凉血汤的前期及临床研究：网络药理学见解及其治疗特应性皮炎的启示
Keke Huang,Qingkai Liu,Ruoxi Zhang et al.
Keke Huang et al.
To investigate the protective effects and underlying mechanisms of Qin-Zhu-Liang-Xue decoction (QZLX) in atopic dermatitis (AD) and glucocorticoid resistance, we conducted a single-blinded, randomized controlled clinical trial to evaluate t...
Decreased neurotensin induces ovulatory dysfunction via the NTSR1/ERK/EGR1 axis in polycystic ovary syndrome [0.03%]
神经紧张素通过NTSR1/ERK/EGR1轴诱导多囊卵巢综合征的排卵功能障碍
Dongshuang Wang,Meiling Zhang,Wang-Sheng Wang et al.
Dongshuang Wang et al.
Polycystic ovary syndrome (PCOS) is the predominant cause of subfertility in reproductive-aged women; however, its pathophysiology remains unknown. Neurotensin (NTS) is a member of the gut-brain peptide family and is involved in ovulation; ...
ChromTR: chromosome detection in raw metaphase cell images via deformable transformers [0.03%]
基于可变形变压器的原始染色体细胞图像识别方法 ChromTR
Chao Xia,Jiyue Wang,Xin You et al.
Chao Xia et al.
Chromosome karyotyping is a critical way to diagnose various hematological malignancies and genetic diseases, of which chromosome detection in raw metaphase cell images is the most critical and challenging step. In this work, focusing on th...