Developing a polygenic risk score for pelvic organ prolapse: a combined risk assessment approach in Chinese women [0.03%]
中国女性盆腔器官脱垂的多基因风险评分的发展：结合风险评估方法
Xi Cheng,Lei Li,Xijuan Lin et al.
Xi Cheng et al.
Pelvic organ prolapse (POP), whose etiology is influenced by genetic and clinical risk factors, considerably impacts women's quality of life. However, the genetic underpinnings in non-European populations and comprehensive risk models integ...
Identification of a nanobody able to catalyze the destruction of the spike-trimer of SARS-CoV-2 [0.03%]
能够催化破坏SARS-CoV-2刺突三聚体的纳米抗体的鉴定
Kai Wang,Duanfang Cao,Lanlan Liu et al.
Kai Wang et al.
Neutralizing antibodies have been designed to specifically target and bind to the receptor binding domain (RBD) of spike (S) protein to block severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus from attaching to angiotensin c...
Aging and metabolic dysfunction-associated steatotic liver disease: a bidirectional relationship [0.03%]
衰老与代谢失常相关脂肪性肝病：相互作用关系
Chen Chen,Lin Wang
Chen Chen
In recent years, aging and cellular senescence have triggered an increased interest in corresponding research fields. Evidence shows that the complex aging process is involved in the development of many chronic liver diseases, such as metab...
Jinming Xiong,Qiaoyue Guo,Xianghang Luo
Jinming Xiong
Aging is typically associated with decreased musculoskeletal function, leading to reduced mobility and increased frailty. As a hallmark of aging, cellular senescence plays a crucial role in various age-related musculoskeletal diseases, incl...
A promising new TERT activator: unraveling the molecular mechanisms behind its natural aging mitigation [0.03%]
一种有前景的TERT激活剂：揭示其延缓自然衰老的分子机制
Qin Li,Fengting Guo,Lanfang Li et al.
Qin Li et al.
Single-cell transcriptome analyses of PBMCs reveal the immunological characteristics of individuals with phlegm-dampness constitution [0.03%]
单细胞转录组分析揭示痰湿体质个体的免疫学特征
Weibo Zhao,Liqiang Zhou,Yixing Wang et al.
Weibo Zhao et al.
Ancient traditional Chinese medicine (TCM) doctrine says "The superior doctor prevents illnesses," pointing out preventative medicine as the ultimate goal for medical care. TCM recognizes that genetic predisposition and environmental and li...
Jingwei Ma,Liang Tang,Jingxuan Xiao et al.
Jingwei Ma et al.
Lactic acid (LA) accumulation in tumor microenvironments (TME) has been implicated in immune suppression and tumor progress. Diverse roles of LA have been elucidated, including microenvironmental pH regulation, signal transduction, post-tra...
Na Kang,Qinghui Duan,Xin Min et al.
Na Kang et al.
B lymphocytes (B cells) play a complex and paradoxical role in tumorigenesis. They can recognize tumor-associated antigens, present these antigens to T cells, and produce antibodies that directly target and eliminate tumor cells. This makes...
Factors involved in human healthy aging: insights from longevity individuals [0.03%]
人类健康老龄化的因素研究：长寿个体的启示
Fan-Qian Yin,Fu-Hui Xiao,Qing-Peng Kong
Fan-Qian Yin
The quest to decipher the determinants of human longevity has intensified with the rise in global life expectancy. Long-lived individuals (LLIs), who exceed the average life expectancy while delaying age-related diseases, serve as a unique ...