Tonic signaling in CAR-T therapy: the lever long enough to move the planet [0.03%]
CAR-T疗法中的辅助信号：足以移动地球的杠杆
Yuwei Huang,Haopeng Wang
Yuwei Huang
Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable efficacy in treating hematological malignancies and is expanding into other indications such as autoimmune diseases, fibrosis, aging and viral infection. However, clinical ...
HOXB13 in cancer development: molecular mechanisms and clinical implications [0.03%]
HOXB13在癌症发生中的分子机制及其临床意义
Jian Zhang,Ying Ju Li,Bo Peng et al.
Jian Zhang et al.
The transcription factor HOXB13 plays crucial roles in cancer development. HOXB13 is abnormally expressed in most cancers, which makes it a valuable therapeutic target for cancer therapy. The level of HOXB13 differs significantly between he...
Qiaomin Hua,Zhixiong Li,Yulan Weng et al.
Qiaomin Hua et al.
Cancer is the result of evolving crosstalk between neoplastic cell and its immune microenvironment. In recent years, immune therapeutics targeting T lymphocytes, such as immune checkpoint blockade (ICB) and CAR-T, have made significant prog...
Low dose of hydroxychloroquine is associated with reduced COVID-19 mortality: a multicenter study in China [0.03%]
低剂量羟氯喹与COVID-19死亡率降低有关：中国多中心研究
Wu He,Ke Xu,Yongcui Yan et al.
Wu He et al.
Update of cellular senescence in kidney fibrosis: from mechanism to potential interventions [0.03%]
肾脏纤维化中细胞衰老的最新进展：从机制到潜在干预手段
Lina Yang,Liang Ma,Ping Fu et al.
Lina Yang et al.
Kidney fibrosis is the final common pathway of virtually all chronic kidney disease (CKD). However, despite great progress in recent years, no targeted antifibrotic therapies have been approved. Epidemiologic, clinical, and molecular eviden...
Advancements in the research of the structure, function, and disease-related roles of ARMC5 [0.03%]
ARMC5结构、功能及其疾病相关作用的研究进展
Yang Qu,Fan Yang,Yafang Deng et al.
Yang Qu et al.
The armadillo repeat containing 5 (ARMC5) gene is part of a family of protein-coding genes that are rich in armadillo repeat sequences, are ubiquitously present in eukaryotes, and mediate interactions between proteins, playing roles in vari...
CHAF1B promotes the progression of lung squamous-cell carcinoma by inhibiting SETD7 expression [0.03%]
CHAF1B通过抑制SETD7表达促进肺鳞状细胞癌进展
Zhuo Zheng,Yongfang Lin,Hua Guo et al.
Zhuo Zheng et al.
The p60 subunit of the chromatin assembly factor-1 complex, that is, chromatin assembly factor-1 subunit B (CHAF1B), is a histone H3/H4 chaperone crucial for the transcriptional regulation of cell differentiation and self-renewal. CHAF1B is...
Inhibition of cap-dependent endonuclease in influenza virus with ADC189: a pre-clinical analysis and phase I trial [0.03%]
ADC189对流感病毒依赖帽子结构的内切酶活性的抑制作用：一项基于临床前分析和Ⅰ期试验的研究
Jing Wei,Yaping Deng,Xiaoyun Zhu et al.
Jing Wei et al.
ADC189 is a novel drug of cap-dependent endonuclease inhibitor. In our study, its antiviral efficacy was evaluated in vitro and in vivo, and compared with baloxavir marboxil and oseltamivir. A first-in-human phase I study in healthy volunte...
Intracellular concentration of ADA2 is a marker for monocyte differentiation and activation [0.03%]
ADA2胞内浓度是单核细胞分化和活化的标志物
Liang Dong,Bingtai Lu,Wenwen Luo et al.
Liang Dong et al.
Adenosine, a critical molecule regulating cellular function both inside and outside cells, is controlled by two human adenosine deaminases: ADA1 and ADA2. While ADA1 primarily resides in the cytoplasm, ADA2 can be transported to lysosomes w...
Unlocking therapeutic potential: antibacterial therapy for CRB1-associated retinal degeneration in Rd8 mice [0.03%]
治疗潜力的开发：用于Rd8小鼠CRB1相关视网膜变性的抗菌疗法
Zhen He,Yufei Wang,Siyu Zhang et al.
Zhen He et al.