Endoplasmic reticulum stress upregulate HYOU1 and mediates lenvatinib resistance in liver cancer through ERK/MAPK pathway [0.03%]
内质网应激通过ERK/MAPK通路上调HYOU1介导仑伐替尼耐药在肝癌中的作用
Xiao Du,Weijia Jiang,Sitong Yan et al.
Xiao Du et al.
Endoplasmic reticulum stress (ERS) is commonly observed in liver cancer and is associated with drug sensitivity. Consequently, ERS-related genes may serve as targets for enhancing treatment sensitivity. This study analyzed RNA and proteomic...
A phase 1/2 pilot study of acupuncture and moxibustion at Zusanli (ST36) as a prophylactic treatment in middle-aged and elderly individuals [0.03%]
电针足三里预防中老年人群患病的I/II期试点研究
Chao Liang,Meihong Fu,Lunsha Deng et al.
Chao Liang et al.
Zusanli (ST36), one of the most essential acupoints in clinical acupuncture practice, is considered as an intervention strategy for disease prevention and longevity promotion in traditional Chinese medicine (TCM). However, the prophylactic ...
Risk assessment of congenital heart defects based on maternal factors in early pregnancy-a systematic review and meta-analysis [0.03%]
基于孕早期母体因素的先天性心脏病风险评估：系统评价和Meta分析
Zihan Suo,Anett Rancz,Árpád Ágoston Jankó et al.
Zihan Suo et al.
Congenital heart defect (CHD) is a leading cause of neonatal mortality, with early maternal risk factors playing a significant role in its development. This systematic review and meta-analysis investigated the relationship between maternal ...
Macrophage-derived semaphorin 7A drives atherosclerosis via the integrin β1/JNK/MSR1 axis [0.03%]
巨噬细胞衍生的sema7a通过整合素β1/jnk/msr1轴促进动脉粥样硬化形成
Fengchan Li,Haofu Ni,Fan Tang et al.
Fengchan Li et al.
Atherosclerosis is a chronic inflammatory disease driven by pathological processes such as macrophage foam cell formation. Semaphorin 7A (SEMA7A) is an immunoregulatory signaling molecule known to modulate immune responses and cellular adhe...
A rare case of fulminant myocarditis complicated with thrombotic aorta occlusion and multiple thrombosis: a case report [0.03%]
急性暴发性心肌炎合并肠系膜上动脉及多发动脉栓塞综合征1例报告
Zongzhe Li,Hua Yan,Yan Wang et al.
Zongzhe Li et al.
Fulminant myocarditis (FM) is an acute inflammatory condition that results in a rapidly progressive, life-threatening circulatory failure and cardiogenic shock. This condition is characterized by severe endotheliitis and concurrent cytokine...
CYP4F11 promotes lung cancer progression through the miR-195/ME2 pathway [0.03%]
CYP4F11通过miR-195/ME2途径促进肺癌进展
Shan Shi,Jiao Zhou,Qiuyun Luo et al.
Shan Shi et al.
The cytochrome P450 enzyme CYP4F11, a pivotal regulator of fatty acid metabolism and drug metabolism, exhibits significantly overexpression in non-small cell lung cancer (NSCLC) and is associated with poor clinical outcomes. Through integra...
Akkermansia muciniphila PROBIO therapy promotes arginine biosynthesis and reverses reproductive impairments in polycystic ovary syndrome rats [0.03%]
Akkermansia muciniphila益生菌治疗促进精氨酸生物合成并逆转多囊卵巢综合征大鼠的生殖障碍
Yifan Wu,Cong Wang,Juanjuan Yu et al.
Yifan Wu et al.
Polycystic ovary syndrome (PCOS) is a prevalent chronic disorder characterized by reproductive, endocrine, and metabolic abnormalities in women worldwide. Increasing evidence has implicated the gut microbiota in the pathogenesis of PCOS, ra...
Sub-threshold depolarization differentially regulated by multiple ion channels plays a key role in initiation of baroreflex afferent neurotransmission evidenced from baroreceptor terminals to its cell bodies [0.03%]
亚阈值去极化通过多个离子通道的差异调节在启动血压感受器传入神经递送中起关键作用：从压力感受器末端到其细胞体中的证据
Yinzhi Xu,Zhaoyuan Xu,Huixiao Fu et al.
Yinzhi Xu et al.
Direct evidence regarding ion channel-mediated initiation of baroreflex/visceral neurotransmission remains limited. Here, aortic-arch, vagus-nodose slice, and isolated neurons were employed with single-fiber/whole-cell patch-clamp recording...
Azvudine remodels the local immunosuppressive microenvironment and exhibits sustained anti-tumor effects in combination with anti-PD-1 therapies [0.03%]
阿唑地平能重塑局部免疫抑制微环境并可与抗PD-1疗法协同发挥持久的抑瘤效果
Limin Jia,Zhaoyang Wang,Jinfa Du et al.
Limin Jia et al.
The immunosuppressive tumor microenvironment (TME) undermines the efficacy of many cancer therapies. This study investigated the immunomodulatory and anti-tumor activity of Azvudine (FNC), alone or in combination with anti-PD-1 blockade. We...
A specific tsRNA in serum from patients with nasopharyngeal carcinoma: 5'tiRNA-32-ValAAC-2 mediates malignance of nasopharyngeal carcinoma cells [0.03%]
鼻咽癌患者血清中的特异性tsRNA：5'tiRNA-32-ValAAC-2通过介导鼻咽癌细胞恶性进展参与NPC发病机制
Qi Tang,Yao Wu,Lin Chen et al.
Qi Tang et al.
Early diagnosis is vitally important for effective treatment of nasopharyngeal carcinoma (NPC). Nevertheless, the exact pathogenic mechanisms of NPC remain unclear, and early diagnosis of NPC is still limited. Herein, we showed that a speci...