Daiming Fan;China Institute for Development Strategy of Holistic Integrative Medicine
Daiming Fan;China Institute for Development Strategy of Holistic Integrative Medicine
ING5 inhibits aerobic glycolysis of lung cancer cells by promoting TIE1-mediated phosphorylation of pyruvate dehydrogenase kinase 1 at Y163 [0.03%]
ING5通过促进TIE1介导的丙酮酸脱氢酶激酶1-Y163磷酸化抑制肺癌细胞的糖酵解
Haihua Zhang,Xinli Liu,Junqiang Li et al.
Haihua Zhang et al.
Aerobic glycolysis is critical for tumor growth and metastasis. Previously, we have found that the overexpression of the inhibitor of growth 5 (ING5) inhibits lung cancer aggressiveness and epithelial-mesenchymal transition (EMT). However, ...
Dronedarone inhibits the proliferation of esophageal squamous cell carcinoma through the CDK4/CDK6-RB1 axis in vitro and in vivo [0.03%]
达罗尼德通过体内和体外的CDK4/6- RB1轴抑制食管鳞状细胞癌增殖
Bo Li,Jing Zhang,Yin Yu et al.
Bo Li et al.
Treatment options for patients with esophageal squamous cell carcinoma (ESCC) often result in poor prognosis and declining health-related quality of life. Screening FDA-approved drugs for cancer chemoprevention is a promising and cost-effic...
Polymorphism in the Hsa-miR-4274 seed region influences the expression of PEX5 and enhances radiotherapy resistance in colorectal cancer [0.03%]
Hsa-miR-4274种子区域的多态性通过影响PEX5表达增强结直肠癌放疗抵抗性
Qixuan Lu,Ningxin Ren,Hongxia Chen et al.
Qixuan Lu et al.
Identifying biomarkers for predicting radiotherapy efficacy is crucial for optimizing personalized treatments. We previously reported that rs1553867776 in the miR-4274 seed region can predict survival in patients with rectal cancer receivin...
Disparities in 36 cancers across 185 countries: secondary analysis of global cancer statistics [0.03%]
全球癌症数据的次级分析：按185个国家划分的36种癌症差异性分析
Qianru Li,Changfa Xia,He Li et al.
Qianru Li et al.
Cancer is a major public health problem and represents substantial disparities worldwide. This study reported estimates for 36 cancers across 185 countries by incidence, mortality, 5-year prevalence, mortality-to-prevalence ratio (MPR), and...
Suboptimal reporting of randomized controlled trials on non-pharmacological therapies in Chinese medicine [0.03%]
中医药非药物疗法随机对照试验的次优报告率研究进展及不足之处
Xuan Zhang,Han Li,Hanzhi Tan et al.
Xuan Zhang et al.
With the successive release of the CONSORT extensions for acupuncture, moxibustion, cupping, and Tuina/massage, this review aims to assess the reporting characteristics and quality of randomized controlled trials (RCTs) based on these speci...
Catalytic activity of Setd2 is essential for embryonic development in mice: establishment of a mouse model harboring patient-derived Setd2 mutation [0.03%]
组蛋白甲基转移酶SETD2催化活性对于胚胎发育必不可少：建立携带SETD2病人突变小鼠模型
Shubei Chen,Dianjia Liu,Bingyi Chen et al.
Shubei Chen et al.
SETD2 is the only enzyme responsible for transcription-coupled histone H3 lysine 36 trimethylation (H3K36me3). Mutations in SETD2 cause human diseases including cancer and developmental defects. In mice, Setd2 is essential for embryonic vas...
Ankita Murmu,Balázs Győrffy
Ankita Murmu
Cancer is a heterogeneous and multifaceted disease with a significant global footprint. Despite substantial technological advancements for battling cancer, early diagnosis and selection of effective treatment remains a challenge. With the c...
Adenosine deaminase 2 regulates the activation of the toll-like receptor 9 in response to nucleic acids [0.03%]
腺苷脱氨酶2调节核酸激活Toll样受体9的功能
Liang Dong,Wenwen Luo,Skaldin Maksym et al.
Liang Dong et al.
Human cells contain two types of adenosine deaminases (ADA) each with unique properties: ADA1, which is present in all cells where it modulates intracellular functions and extracellular signaling, and ADA2, which is secreted by immune cells...
Prevalence of anemia of varying severity, geographic variations, and association with metabolic factors among women of reproductive age in China: a nationwide, population-based study [0.03%]
中国育龄妇女不同严重程度贫血的患病率、地区差异及其与代谢因素关联的全国性流行病学研究
Heling Bao,Yuanyuan Huang,Yi Sun et al.
Heling Bao et al.
To investigate the epidemiological characteristics of anemia of varying severity among women of reproductive age, we conducted a nationwide, cross-sectional study between January 1, 2019 and December 31, 2019, including 4 184 547 nonpregnan...