First evidence of olaparib maintenance therapy in patients with newly diagnosed homologous recombination deficient positive/BRCA wild-type ovarian cancer: real-world multicenter study [0.03%]
奥拉帕利在新诊断的同源重组修复缺陷阳性且BRCA野生型卵巢癌患者中维持治疗的真实世界多中心研究的初步证据
Jing Li,Youguo Chen,Mian He et al.
Jing Li et al.
Although olaparib has demonstrated substantial clinical benefits as maintenance therapy in BRCA mutation-carrying women with newly diagnosed advanced ovarian cancer, its effectiveness in patients without BRCA mutations remains poorly invest...
Multicenter Study
Frontiers of medicine. 2024 Dec;18(6):1026-1034. DOI:10.1007/s11684-024-1083-5 2024
Dysregulated inclusion of BOLA3 exon 3 promoted by HNRNPC accelerates the progression of esophageal squamous cell carcinoma [0.03%]
由HNRNPC促进的BOLA3第3外显子失调纳入可加速食管鳞状细胞癌进展
Bo Tian,Yan Bian,Yanan Pang et al.
Bo Tian et al.
Dysregulated RNA splicing events produce transcripts that facilitate esophageal squamous cell carcinoma (ESCC) progression, but how this splicing process is abnormally regulated remains elusive. Here, we unveiled a novel alternative splicin...
Single-cell transcriptome profiling identifies the activation of type I interferon signaling in ossified posterior longitudinal ligament [0.03%]
单细胞转录组分析鉴定出退变黄韧带骨化激活I型干扰素信号通路
Xiao Liu,Lei Zhang,Ge Wang et al.
Xiao Liu et al.
Ossification of the posterior longitudinal ligament (OPLL) is a condition comprising ectopic bone formation from spinal ligaments. This disease is a leading cause of myelopathy in the Asian population. However, the molecular mechanism under...
The novel anthraquinone compound Kanglexin prevents endothelial-to-mesenchymal transition in atherosclerosis by activating FGFR1 and suppressing integrin β1/TGFβ signaling [0.03%]
新型蒽醌化合物康莱迪防治动脉粥样硬化内皮细胞间质转化的机制研究：激活FGFR1信号及抑制整合素β1-TGF-β信号路径的作用
Yixiu Zhao,Zhiqi Wang,Jing Ren et al.
Yixiu Zhao et al.
Endothelial-mesenchymal transition (EndMT) disrupts vascular endothelial integrity and induces atherosclerosis. Active integrin β1 plays a pivotal role in promoting EndMT by facilitating TGFβ/Smad signaling in endothelial cells. Here, we ...
Limei Wang,Denghui Lu,Maosen Yang et al.
Limei Wang et al.
Nipah virus (NiV) is a zoonotic paramyxovirus that has recently emerged as a crucial public health issue. It can elicit severe encephalitis and respiratory diseases in animals and humans, leading to fatal outcomes, exhibiting a wide range o...
First insights into genotype and phenotype of familial amyotrophic lateral sclerosis in Egypt: early onset and high consanguinity [0.03%]
埃及遗传性肌萎缩侧索硬化的基因型和表型的初步见解：发病年龄早、近亲结婚比例高
Nabila Hamdi,Kathrin Mueller,Amr Hamza et al.
Nabila Hamdi et al.
Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis [0.03%]
整合型全基因组分析识别汉族人IgA肾病的易感基因位点及相关的细胞类型
Ming Li,Xingjie Hao,Dianchun Shi et al.
Ming Li et al.
Although many susceptibility loci for IgA nephropathy (IgAN) have been identified, they only account for 11.0% of the overall IgAN variance. We performed a large genome-wide meta-analysis of IgAN in Han Chinese with 3616 cases and 10 417 co...
Meta-Analysis
Frontiers of medicine. 2024 Oct;18(5):862-877. DOI:10.1007/s11684-024-1086-2 2024
Yingying Huang,Zhigang Tian,Jiacheng Bi
Yingying Huang
Natural killer (NK) cells are key innate immune lymphocytes, which play important roles against tumors. However, tumor-infiltrating NK cells are always hypofunctional/exhaustive. On the one hand, this state is contributed by context-depende...
Yimin Liu,Haitao Li
Yimin Liu
PAK5-mediated PKM2 phosphorylation is critical for anaerobic glycolysis in endometriosis [0.03%]
PAK5介导的PKM2磷酸化在子宫内膜异位症缺氧诱导的糖酵解中起关键作用
Jiayi Lu,Xiaoyun Wang,Xiaodan Shi et al.
Jiayi Lu et al.
P21-activated kinase 5 (PAK5) belongs to the PAK-II subfamily, which is an important regulator of cell survival, adhesion, and motility. However, the functions of PAK5 in endometriosis remain unclear. Here, PAK5 is strikingly upregulated in...