TRIM4 modulates the ubiquitin-mediated degradation of hnRNPDL and weakens sensitivity to CDK4/6 inhibitor in ovarian cancer [0.03%]
TRIM4通过泛素化介导hnRNPD的降解并削弱卵巢癌细胞对CDK4/6抑制剂的敏感性
Xiaoxia Che,Xin Guan,Yiyin Ruan et al.
Xiaoxia Che et al.
Ovarian cancer is the most lethal malignancy affecting the female reproductive system. Pharmacological inhibitors targeting CDK4/6 have demonstrated promising efficacy across various cancer types. However, their clinical benefits in ovarian...
Allogeneic hematopoietic stem cell transplantation could overcome the poor prognosis of DNMT3AmutNPM1mutFLT3-ITDmut in acute myeloid leukemia: real-world multicenter analysis in China [0.03%]
同种异体造血干细胞移植可能克服急性髓系白血病中DNMT3AmutNPM1mutFLT3-ITDmut预后不良的情况：中国多中心真实世界分析
Wenxuan Huo,Yifan Shen,Jiayu Huang et al.
Wenxuan Huo et al.
The cooccurrence of NPM1, FLT3-ITD, and DNMT3A mutations (i.e., triple mutation) is related to dismal prognosis in patients with acute myeloid leukemia (AML) receiving chemotherapy alone. In this multicenter retrospective cohort study, we a...
Gamze Sonmez,Baris Ulum,Ates Kutay Tenekeci et al.
Gamze Sonmez et al.
Cytoskeletal network dysregulation is a pivotal determinant in various immunodeficiencies and autoinflammatory conditions. This report reviews the significance of actin remodeling in disease pathogenesis, focusing on the Arp2/3 complex and ...
Prevalence and associated risk factors of carotid plaque and artery stenosis in China: a population-based study [0.03%]
中国颈动脉斑块和狭窄的患病率及其相关危险因素流行病学研究
Qingjia Zeng,Chongyang Zhang,Xinyao Liu et al.
Qingjia Zeng et al.
Stroke is a critical health issue in China, and carotid artery stenosis and plaque play key roles in its prevalence. Despite the acknowledged significance of this condition, detailed information regarding the prevalence of carotid artery st...
Mitochondrial-associated programmed-cell-death patterns for predicting the prognosis of non-small-cell lung cancer [0.03%]
线粒体相关程序性细胞死亡模式预测非小细胞肺癌预后
Xueyan Shi,Sichong Han,Guizhen Wang et al.
Xueyan Shi et al.
Mitochondria are the convergence point of multiple pathways that trigger programmed cell death (PCD). Mitochondrial-associated PCD (mtPCD) is involved in the pathogenesis of several diseases. However, the role of mtPCD in the prognostic pre...
Incidence and risk factors of female sexual dysfunction in urban and rural China: a 4-year prospective cohort study [0.03%]
中国城市和农村地区女性性功能障碍的发病率及危险因素——一项为期四年的前瞻性队列研究
Haiyu Pang,Mingyu Si,Tao Xu et al.
Haiyu Pang et al.
This study aimed to investigate the incidence and risk factors for female sexual dysfunction (FSD) in urban and rural China. A prospective cohort study was conducted from February 2014 to January 2016, with follow-up from June to December 2...
Nina He,Dun Yuan,Minjie Luo et al.
Nina He et al.
As a novel form of cell death, ferroptosis is mainly regulated by the accumulation of soluble iron ions in the cytoplasm and the production of lipid peroxides and is closely associated with several diseases, including acute kidney injury, i...
Yueying Li,Kunying Chen,Qian-Fei Wang
Yueying Li
Megakaryocytes (MKs), which are traditionally known for their role in platelet production, are now emerging as unique immune cells with diverse capabilities. They express immune receptors, participate in pathogen recognition and response, p...
Novel perspectives on the link between obesity and cancer risk: from mechanisms to clinical implications [0.03%]
肥胖与癌症风险关联的新视角：从机制到临床意义
Xiaoye Shi,Aimin Jiang,Zhengang Qiu et al.
Xiaoye Shi et al.
Existing epidemiologic and clinical studies have demonstrated that obesity is associated with the risk of a variety of cancers. In recent years, an increasing number of experimental and clinical studies have unraveled the complex relationsh...
Enhancing patient activation: a controlled implementation study of an interprofessional evidence-based counseling program for complementary and integrative healthcare in cancer patients ('CCC-Integrativ') [0.03%]
改善患者激活作用：一项关于在癌症患者中实施基于循证的跨学科补充和整合医疗服务咨询项目（“CCC-整合”）的控制实现研究
Jan Valentini,Daniela Froehlich,Inka Roesel et al.
Jan Valentini et al.
Complementary and integrative healthcare (CIH) is increasingly recognized as a valuable approach to empowering and activating cancer patients. Studies have shown that higher patient activation is positively associated with improved health o...
Multicenter Study
Frontiers of medicine. 2024 Dec;18(6):1013-1025. DOI:10.1007/s11684-024-1097-z 2024