Cerebral organoids and organoid intelligence: ethical challenges and governance pathway [0.03%]
脑类器官与类脑智能：伦理挑战及治理路径
Huiyu Luo,Xiangdong Xie
Huiyu Luo
Immune cells in diabetic wound repair: the key to better wound management [0.03%]
免疫细胞在糖尿病伤口愈合中的作用：更好的伤口管理的关键
Yi Ru,Yunxi Cai,Guangyuan Cheng et al.
Yi Ru et al.
Chronic diabetic ulcers (DUs) pose a significant clinical challenge with high amputation and mortality rates, impacting over 131 million people worldwide and incurring approximately $755 billion in annual healthcare costs. Immune cells play...
LMWH prophylaxis in pregnancy outcomes of women with suspected protein S deficiency: a retrospective case-control study [0.03%]
疑似蛋白S缺乏的孕妇使用低分子量肝素预后的病例对照研究
Mengtong Zang,Zhuoyu An,Yuxiu Chen et al.
Mengtong Zang et al.
Given the maternal hypercoagulability during pregnancy, thrombophilia may increase the risk of adverse pregnancy outcomes (APOs). This retrospective case-control study aimed to assess whether low-molecular-weight heparin (LMWH) could improv...
Yuan Lin,Jennifer Wang,Xin Liu et al.
Yuan Lin et al.
Cardiovascular disease remains the foremost contributor to mortality and disability globally, even with significant advancements in prevention, diagnosis, and early intervention. A comprehensive insight into cardiovascular diseases and the ...
Prognostic utility of baseline ASCL1/INSM1 expression and neutrophil-lymphocyte ratio in unresectable SCLC treated with first-line chemoimmunotherapy with or without radiotherapy [0.03%]
基线ASCL1/INSM1表达和中性粒细胞淋巴细胞比值对初诊不可手术小细胞肺癌化疗免疫治疗联合或不联合放疗预后价值的评估
Yanli Zhu,Sheng Li,Hanxiao Chen et al.
Yanli Zhu et al.
While immune checkpoint inhibitors have revolutionized small cell lung carcinoma (SCLC) management, clinical benefits remain restricted to a subset of patients. This study investigates baseline biomarkers for predicting outcomes in unresect...
"Zero-distance" photocrosslinking: a paradigm shift in probing DNA-protein dynamics [0.03%]
“零距离”光交联法：探测DNA-蛋白动态行为的范式转变
Fengting Guo,Sisi Fan,Xueqian Ouyang et al.
Fengting Guo et al.
Risk prediction and therapeutic targets for incident pulmonary hypertension: a large-scale proteomic profiling and Mendelian randomization study [0.03%]
预测肺动脉高压发病风险及治疗靶点的蛋白质组学和孟德尔随机化研究
Yuanyuan Zhang,Yan Zhang,Sisi Yang et al.
Yuanyuan Zhang et al.
We aimed to identify plasma proteins associated with pulmonary hypertension (PH) risk, discover potential therapeutic targets for PH, and develop and validate a protein-based prediction model. The development cohort included 38 499 UK Bioba...
ASPH interacts with RUVBL2 to promote tumor metastasis in lung adenocarcinoma via MAPK and Notch signaling pathways [0.03%]
ASPH通过MAPK和Notch信号通路与RUVBL2相互作用促进肺腺癌肿瘤转移
Chuhong Huang,Huihao Lu,Jiali Dong et al.
Chuhong Huang et al.
Aspartate/asparagine-β-hydroxylase (ASPH), a type II transmembrane α-ketoglutarate-dependent hydroxylase, is frequently overexpressed in various cancers. However, its role in lung adenocarcinoma (LUAD) remains unclear. Here, we analyzed A...
Comparative analysis reveals distinct molecular heterogeneity in vaginal cells between recurrent and primary pelvic organ prolapse patients [0.03%]
比较分析发现复发性和原发性盆腔器官脱垂患者阴道细胞的分子异质性不同
Yaqian Li,Yiwei Zhang,Rui Wang et al.
Yaqian Li et al.
High recurrence rate in pelvic organ prolapse (POP) seriously increases treatment difficulty and elucidating the mechanisms is critical for developing targeted therapies. However, its underlying molecular mechanisms remain unclear. Using a ...
ILKAP drives hepatocellular carcinoma progression by modulating PGAM1-mediated glycolytic reprogramming [0.03%]
通过调节PGAM1介导的糖酵解重构驱动肝细胞癌进展
Juejiashan Li,Yihong Chen,Qiyi Qian et al.
Juejiashan Li et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, necessitating novel therapeutic targets. This study explores the oncogenic role of integrin-linked kinase-associated phosphatase (ILKAP) in HCC and its underlyin...