Tumor microenvironment-driven drug resistance in urologic cancers: mechanisms and therapeutic targets [0.03%]
泌尿系统肿瘤微环境诱导的药物抵抗机制及治疗靶点研究进展
Gi-Eun Yang,Seo-Yeong Yoon,Ju-Seog Lee et al.
Gi-Eun Yang et al.
Therapeutic resistance remains a major challenge in the management of urologic cancers, including renal cell carcinoma (RCC), bladder cancer (BC), and prostate cancer (PCa). Recent advances highlight the tumor microenvironment (TME) as a cr...
Integrated analysis identifies conserved transcription factors TCF12, E2F1, and TEAD4 with diagnostic and therapeutic value in osteoarthritis subchondral bone [0.03%]
整合分析确定TCF12、E2F1和TEAD4转录因子在骨关节炎软骨下骨的诊断和治疗中的价值
Jingyang Cheng,Rulong Cai,Wei Lu et al.
Jingyang Cheng et al.
Background: Osteoarthritis (OA) is a multifactorial joint disease involving both cartilage and subchondral bone. The molecular mechanism of subchondral bone in OA is still unclear. ...
MicroRNA-124 induces AML differentiation and apoptosis through c-Myc suppression [0.03%]
microRNA-124通过下调c-Myc促进急性髓系白血病分化和凋亡
Byeol-Eun Jeon,Chan-Seong Kwon,Ji-Eun Lee et al.
Byeol-Eun Jeon et al.
Background: Acute myeloid leukemia (AML) is a hematologic malignancy marked by blocked differentiation and uncontrolled proliferation. While miR-124 has been implicated as a tumor suppressor in various cancers, its functi...
Deciphering the molecular landscape of hepatopancreatic necrosis disease in Eriocheir sinensis using RNA-Seq meta-analysis [0.03%]
基于RNA测序的meta分析破解克氏原螯虾肝胰腺坏死病分子图谱
Adeel Malik,Nitin Mahajan,Hyung-Eun An et al.
Adeel Malik et al.
Background: The Chinese mitten crab (Eriocheir sinensis) is a commercially important crustacean, highly valued in China and Korean peninsula for its nutritional benefits and delicate flavor. However, the aquaculture indus...
Dharmendra Kumar Nath,Nabin Rana,Youngseok Lee
Dharmendra Kumar Nath
Comprehensive in silico analysis of Acinetobacter isolates from South Korea reveals genomic diversity, antimicrobial resistance, virulence factors, and evolutionary dynamics [0.03%]
来自韩国的不动杆菌菌株的全面计算分析揭示了基因组多样性、抗菌药物耐药性、毒力因子和进化动力学
Md Minarul Islam,Kyudong Han,Kyungho Woo et al.
Md Minarul Islam et al.
Integrated transcriptomic and 16S rRNA analyses reveal colon and brain barrier-preserving effects of red radish (Raphanus sativus L.) sprout supplementation in high-fat diet-fed mice [0.03%]
整合转录组和16S rRNA分析揭示了高脂饮食小鼠食用红萝卜发芽后的结肠和大脑屏障保护效应
Kyung-Wan Baek,Kyoungeui Yun,Mei Tong He et al.
Kyung-Wan Baek et al.
Background: Radish sprouts (Raphanus sativus L.) are rich in dietary fibers and phytochemicals with antioxidant and anti-inflammatory activities. However, their whole-food effects on the gut-brain axis remain poorly defin...
The role of Alu elements in causing BRCA1 structural variation and breast cancer susceptibility [0.03%]
Alu元件在BRCA1结构变异和乳腺癌易感性中的作用
Minjae Yu,Dahee Jo,Wonseok Shin et al.
Minjae Yu et al.
BRCA1 is a tumor suppressor gene encoding a protein which plays an essential role in the repair of DNA double strand break. Approximately 40% of its introns are composed of Alu elements. It is known that retrotransposons create an environme...
Transcriptome-based screening of regulator genes for sexual dimorphism in pupae of Callipogon relictus [0.03%]
基于转录组的性别二态性差异调节基因筛选及功能验证
Kyoung-Bin Ryu,Geon Woo Lee,Sangil Kim et al.
Kyoung-Bin Ryu et al.
Background: Sexual dimorphism in insects arises from morphological, physiological, and behavioral differences that often reflect reproductive strategies. However, its molecular basis remains poorly understood in non-model...
Hanbyul Song,Md Mozaffar Hosain,Taesung Park
Hanbyul Song
Background: The high prevalence of non-biological zero counts, arising from low sequencing depth and sampling variation, presents a significant challenge in microbiome data analysis. These zeros can distort taxon abundanc...