Integrative analysis of TCGA data identifies hsa-miR-200a as a breast cancer-associated microRNA biomarker with exploratory serum validation [0.03%]
TCGA数据集的综合分析鉴定出乳腺癌相关微小核糖核酸生物标志物hsa-miR-200a及其血清学验证研究
Kwangmin Park,Eun You Kim,Eun Ju Lee et al.
Kwangmin Park et al.
Background: Breast cancer is a biologically heterogeneous disease, and reliable non-invasive biomarkers are needed to improve early detection and clinical risk stratification. MicroRNAs (miRNAs) represent promising diagno...
Quantum computing-assisted validation of a conserved macrophage suppression module shared by ASFV and PEDV [0.03%]
量子计算辅助验证 ASFV 和 PEDV 共享的保守型巨噬细胞抑制模块
Jongwon Byun,Hakjin Kim,Changhee Chandler Pyo et al.
Jongwon Byun et al.
Background: African swine fever virus (ASFV) and porcine epidemic diarrhea virus (PEDV) differ in viral biology and cellular tropism, yet both pathogens suppress macrophage-mediated immune responses in pigs. ...
Inhibition of PI3K/AKT/mTOR pathway suppresses growth of oral squamous cell carcinoma in 2D and 3D in vitro model and animal model [0.03%]
PI3K/AKT/m TOR通路抑制阻断了二维和三维体外模型及动物模型中舌鳞状细胞癌的生长
Hui Xu,Xin Luo,Xin He et al.
Hui Xu et al.
Background: Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive malignancy with a high rate of recurrence and poor prognosis. The PI3K/AKT/mTOR signaling pathway plays a pivotal role in cancer progression by...
A digital PCR-based platform for rapid assessment of chloroplast stress adaptation in microalgal metabolic engineering [0.03%]
一种基于数字PCR的平台技术可快速评估微藻代谢工程中叶绿体胁迫适应性
Jinuk Jeong,Seohyun Park,Kornsorn Srikulnath et al.
Jinuk Jeong et al.
Microalgae rapidly adjust their chloroplast physiology in response to environmental stress, and these adaptive responses are closely associated with cellular fitness and metabolic performance. However, conventional assessments of stress ada...
Characterization of a draft chromosome-scale genome assembly for the mutton snapper, Lutjanus analis [0.03%]
囊斑鳞虾虎鱼（Lutjanus analis）染色体规模基因组草图的特征分析
Lora G Holman,Tami Hildahl,Eric Saillant
Lora G Holman
Background: The mutton snapper (Lutjanus analis) is a reef fish commonly found in tropical waters of the Western Atlantic Ocean. Genomic studies of this species are needed to support conservation efforts and breeding prog...
GWAS-based identification of a candidate gene and development of a predictive KASP marker for seed protein and oil contents in soybean [0.03%]
基于GWAS的候选基因鉴定及大豆种子蛋白和油脂含量预测KASP标记开发
Jeong Woo Lee,Jung Min Kim,Dae June Kim et al.
Jeong Woo Lee et al.
Background: Soybean [Glycine max (L.) Merrill] is one of the most widely cultivated crops worldwide. Its seeds contain about 40% protein and 20% oil, serving as essential nutrient sources for humans. Given the nutritional...
ONT-only genome assembly of a Korean male individual using a semen sample [0.03%]
使用精液样本进行韩国男性个体的无细胞基因组测序及从头组装
Jian Lee,Ji-Hwan Park,Soobok Joe et al.
Jian Lee et al.
Background: Long-read sequencing has enabled the generation of high-quality human genome assemblies, but many previous assemblies were based on blood-derived DNA and often relied on limited data types from a single sequen...
Subtype-specific clinical significance of RRM1 and RRM2 expression in non-small cell lung cancer: a TCGA-based analysis [0.03%]
RRM1和RRM2在非小细胞肺癌中的亚型特异性临床意义（基于TCGA数据库的分析）
Se-Young Yun,Yunha Lee,Junchae Lee et al.
Se-Young Yun et al.
Background: Non-small cell lung cancer (NSCLC), including lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), exhibits significant molecular heterogeneity. Ribonucleotide reductase (RNR), composed of RRM1 ...
Transcriptome mining and comparative genomics reveal 36 putative novel marafivirus species and conserved evolution of the marafibox regulatory element [0.03%]
转录组挖掘和比较基因组揭示了36种假想的新型马拉菲病毒物种以及马拉菲框调节元件的保守进化
Dongjin Choi,Seungwoo Baek,Myeung Seok Choi et al.
Dongjin Choi et al.
Background: Marafiviruses are plant-infecting RNA viruses associated with several economically important crops, but their genomic diversity remains incompletely characterized. ...
Baicalein alleviates high glucose-induced mesangial cell fibrosis and inflammation in diabetic nephropathy: roles of AMPK activation and TGF-β1 inhibition [0.03%]
黄芩素通过激活AMPK和抑制TGF-β1缓解糖尿病肾病中高糖诱导的系膜细胞纤维化和炎症损伤
Hongtao Tan,Yingshan Li,Yicong Li et al.
Hongtao Tan et al.
Background: Diabetic nephropathy (DN), a major diabetic microvascular complication, is the primary cause of end-stage renal disease worldwide. It is characterized by mesangial cell fibrosis and chronic inflammation, which...