De novo identification and differential expression of MicroRNA in the Lebbeus groenlandicus [0.03%]
格陵兰沙蚕中miRNA的从头鉴定与差异表达分析
Du Hyeong Lee,Hae Jin Shin,Woo Ryung Kim et al.
Du Hyeong Lee et al.
A novel duplication mutation in the MYO7A gene associated with autosomal recessive hearing loss in a Chinese family [0.03%]
MYO7A基因的新重复突变与一个中国家系的常染色体隐性遗传听力损失相关
Jie Li,Shengmei Yang,Mina Xiang et al.
Jie Li et al.
Antarctic soil microbiomes as a reservoir for cosmetic bioactives: continental-scale diversity and predicted functions [0.03%]
作为化妆品活性成分来源的南极土壤微生物库：大陆范围内的多样性和预测功能
Giuk Gim,Dong-Geol Lee,Chun Ho Park et al.
Giuk Gim et al.
Background: Demand for clean beauty ingredients is driving discovery of safe, effective, and sustainable actives. Microbes inhabiting polar deserts produce biomolecules adapted to stress, relevant to skin protection and r...
Genome-wide association study of quantitative ocular traits, including axial length and central corneal thickness, identifies loci for refractive error in the Korean population [0.03%]
包括轴长和中央角膜厚度的定量眼部特征全基因组关联研究鉴定出韩国人近视相关易感位点
Woo Young Lim,Kui Dong Kang,Yoon Shin Cho
Woo Young Lim
Background: The eye is a sensory organ that receives light and generates visual information. Refractive errors, which are influenced by both genetic and environmental factors, are a major cause of visual impairment. In pa...
Inhibition of MID1IP1 induces ferroptosis and suppresses c-Myc expression in colorectal cancer cell [0.03%]
MID1IP1的抑制诱导结直肠癌细胞铁死亡并抑制c-Myc表达
Je Joung Oh,Yu Jin Lee,Yeo Jeong Han et al.
Je Joung Oh et al.
Background: Colorectal cancer (CRC) is the third most diagnosed cancer worldwide. Despite treatment advances, CRC still requires novel strategies to overcome drug resistance and metastasis. Midline 1 Interacting Protein 1...
Multiple machine learning algorithms construct cuproptosis genes and oxidative stress genes-related LncRNAs signature with prognostic and therapeutic relevance in ovarian cancer [0.03%]
用于预测卵巢癌患者预后的多个机器学习算法构建的与铜死亡基因和氧化应激基因相关的长链非编码RNA标志物及其治疗意义
Ruyue Pan,Yan Yang,Qinghuo Kong et al.
Ruyue Pan et al.
Background: Cuproptosis and oxidative stress (COS) are emerging regulators in cancer biology. However, their link to long non-coding RNAs (lncRNAs) and clinical outcomes in ovarian cancer remains unclear. ...
Single-cell transcriptomic analysis reveals cellular and molecular changes in EGFR-positive lung adenocarcinoma before and after Furmonertinib treatment [0.03%]
单细胞转录组分析揭示了泛伊瑞莎治疗前后EGFR阳性肺腺癌的细胞和分子变化
Jian Chen,Minghui Cai,Lifei Meng et al.
Jian Chen et al.
Background: Lung adenocarcinoma (LUAD) frequently harbors activating mutations in the epidermal growth factor receptor (EGFR), making EGFR tyrosine kinase inhibitors (EGFR-TKIs) a critical component of targeted therapy. A...
Tumor microenvironment-driven drug resistance in urologic cancers: mechanisms and therapeutic targets [0.03%]
泌尿系统肿瘤微环境诱导的药物抵抗机制及治疗靶点研究进展
Gi-Eun Yang,Seo-Yeong Yoon,Ju-Seog Lee et al.
Gi-Eun Yang et al.
Therapeutic resistance remains a major challenge in the management of urologic cancers, including renal cell carcinoma (RCC), bladder cancer (BC), and prostate cancer (PCa). Recent advances highlight the tumor microenvironment (TME) as a cr...
Integrated analysis identifies conserved transcription factors TCF12, E2F1, and TEAD4 with diagnostic and therapeutic value in osteoarthritis subchondral bone [0.03%]
整合分析确定TCF12、E2F1和TEAD4转录因子在骨关节炎软骨下骨的诊断和治疗中的价值
Jingyang Cheng,Rulong Cai,Wei Lu et al.
Jingyang Cheng et al.
Background: Osteoarthritis (OA) is a multifactorial joint disease involving both cartilage and subchondral bone. The molecular mechanism of subchondral bone in OA is still unclear. ...
MicroRNA-124 induces AML differentiation and apoptosis through c-Myc suppression [0.03%]
microRNA-124通过下调c-Myc促进急性髓系白血病分化和凋亡
Byeol-Eun Jeon,Chan-Seong Kwon,Ji-Eun Lee et al.
Byeol-Eun Jeon et al.
Background: Acute myeloid leukemia (AML) is a hematologic malignancy marked by blocked differentiation and uncontrolled proliferation. While miR-124 has been implicated as a tumor suppressor in various cancers, its functi...