Multi-omics analysis identifies SMPD1 as a key contributor in sphingolipid pathway for Type 2 diabetes pathogenesis [0.03%]
多组学分析揭示SMPD1在2型糖尿病发病机制中的鞘脂途径中的关键作用
Aron Park,Baeki E Kang,Eun-Ju Jin et al.
Aron Park et al.
Background: Type 2 diabetes (T2D) is a complex and heterogeneous metabolic disorder that presents significant challenges in treatment development. Emerging evidence indicates that T2D is closely associated with dysregulat...
Clariid catfish hybridization in aquaculture: a comprehensive review of strategies, challenges, and future directions [0.03%]
养殖用裂吻鱼杂交：策略、挑战及未来方向的全面综述
Ukam Uno,Uduak Edem,Thitipong Panthum et al.
Ukam Uno et al.
Background: Hybridization within the family Clariidae has been recognized as a crucial strategy for genetic improvement in aquaculture, particularly in Asia and Africa, due to its potential to enhance growth, feed efficie...
Molecular remodeling of the central auditory pathway in tinnitus revealed by RNA sequencing [0.03%]
通过RNA测序揭示的耳鸣中枢听觉通路分子重塑现象
Ha Hyun Song,Byeonghyeon Lee,Hyeon Joon Shin et al.
Ha Hyun Song et al.
Background: Tinnitus is a complex neurological condition affecting 10-15% of adults worldwide, characterized by phantom auditory perception without external sound sources. While traditional investigations have focused on ...
De novo identification and differential expression of MicroRNA in the Lebbeus groenlandicus [0.03%]
格陵兰沙蚕中miRNA的从头鉴定与差异表达分析
Du Hyeong Lee,Hae Jin Shin,Woo Ryung Kim et al.
Du Hyeong Lee et al.
A novel duplication mutation in the MYO7A gene associated with autosomal recessive hearing loss in a Chinese family [0.03%]
MYO7A基因的新重复突变与一个中国家系的常染色体隐性遗传听力损失相关
Jie Li,Shengmei Yang,Mina Xiang et al.
Jie Li et al.
Antarctic soil microbiomes as a reservoir for cosmetic bioactives: continental-scale diversity and predicted functions [0.03%]
作为化妆品活性成分来源的南极土壤微生物库：大陆范围内的多样性和预测功能
Giuk Gim,Dong-Geol Lee,Chun Ho Park et al.
Giuk Gim et al.
Background: Demand for clean beauty ingredients is driving discovery of safe, effective, and sustainable actives. Microbes inhabiting polar deserts produce biomolecules adapted to stress, relevant to skin protection and r...
Genome-wide association study of quantitative ocular traits, including axial length and central corneal thickness, identifies loci for refractive error in the Korean population [0.03%]
包括轴长和中央角膜厚度的定量眼部特征全基因组关联研究鉴定出韩国人近视相关易感位点
Woo Young Lim,Kui Dong Kang,Yoon Shin Cho
Woo Young Lim
Background: The eye is a sensory organ that receives light and generates visual information. Refractive errors, which are influenced by both genetic and environmental factors, are a major cause of visual impairment. In pa...
Inhibition of MID1IP1 induces ferroptosis and suppresses c-Myc expression in colorectal cancer cell [0.03%]
MID1IP1的抑制诱导结直肠癌细胞铁死亡并抑制c-Myc表达
Je Joung Oh,Yu Jin Lee,Yeo Jeong Han et al.
Je Joung Oh et al.
Background: Colorectal cancer (CRC) is the third most diagnosed cancer worldwide. Despite treatment advances, CRC still requires novel strategies to overcome drug resistance and metastasis. Midline 1 Interacting Protein 1...
Multiple machine learning algorithms construct cuproptosis genes and oxidative stress genes-related LncRNAs signature with prognostic and therapeutic relevance in ovarian cancer [0.03%]
用于预测卵巢癌患者预后的多个机器学习算法构建的与铜死亡基因和氧化应激基因相关的长链非编码RNA标志物及其治疗意义
Ruyue Pan,Yan Yang,Qinghuo Kong et al.
Ruyue Pan et al.
Background: Cuproptosis and oxidative stress (COS) are emerging regulators in cancer biology. However, their link to long non-coding RNAs (lncRNAs) and clinical outcomes in ovarian cancer remains unclear. ...
Single-cell transcriptomic analysis reveals cellular and molecular changes in EGFR-positive lung adenocarcinoma before and after Furmonertinib treatment [0.03%]
单细胞转录组分析揭示了泛伊瑞莎治疗前后EGFR阳性肺腺癌的细胞和分子变化
Jian Chen,Minghui Cai,Lifei Meng et al.
Jian Chen et al.
Background: Lung adenocarcinoma (LUAD) frequently harbors activating mutations in the epidermal growth factor receptor (EGFR), making EGFR tyrosine kinase inhibitors (EGFR-TKIs) a critical component of targeted therapy. A...