GWAS reveals common SLX4 variants associated with telomere length and hypertension in individuals of African ancestry [0.03%]
基于非洲血统人群的基因组-wide关联研究揭示了与端粒长度和高血压相关的SLX4常见变异体
Nicole Benfield,Prisca K Thami,James Ware et al.
Nicole Benfield et al.
Nrf2-dependent redox regulation protects myoblasts from polystyrene nanoplastic-induced premature senescence [0.03%]
Nrf2依赖性红ox调节保护肌管细胞免受聚苯乙烯纳米塑料引起的过早衰老
Chae Rin Jung,EunJin Bang,Gi-Young Kim et al.
Chae Rin Jung et al.
Background: Nanoplastics (NPs) have emerged as environmental contaminants posing potential risks to human health. Recently, skeletal muscle has been recognized as a target tissue affected by NP exposure, where NPs trigger...
Advanced molecular techniques in distinguishing monozygotic twins for forensic applications [0.03%]
用于法医鉴定的区分同卵双胞胎的高级分子技术
Hirak Ranjan Dash
Hirak Ranjan Dash
Despite significant advancements in the forensic DNA analysis techniques, one of the major limitations is the availability of a gold standard genetic technique to distinguishing the monozygotic (MZ) twins. NGS mediated deep sequencing appro...
Novel citrivirus and prunevirus genomes further demonstrate the recurrent, independent acquisition of nucleic acid-binding proteins in the family Betaflexiviridae [0.03%]
新的柑橘病毒和李属病毒基因组进一步证明了核酸结合蛋白在贝塔卷曲病毒科中的反复独立获得现象
Hyerin Park,Dongjin Choi,Seungwoo Baek et al.
Hyerin Park et al.
Background: Some plant RNA viruses in the family Betaflexiviridae encode a nucleic acid-binding protein (NABP), which enhances viral infectivity. Until recently, Salvia divinorum RNA virus 1 (SdRV1) was the only known mem...
Analysis of genetic mutation characteristics in 40 Chinese patients with hepatocellular carcinoma [0.03%]
40例中国肝细胞癌患者基因突变特征分析
Shaoshao Xu,Lei Li,Dongchang Yang et al.
Shaoshao Xu et al.
Background: Hepatocellular carcinoma (HCC) is notable for its marked molecular heterogeneity and poor response to systemic therapy. Targeted next-generation sequencing (NGS) has facilitated the profiling of somatic altera...
Synergistic antitumor activity of CAR-NK cells combined with CAR-macrophages for pancreatic cancer treatment [0.03%]
CAR-NK细胞联合CAR-巨噬细胞协同治疗胰腺癌的抗肿瘤活性
Dana Jung,Seo-Gyeong Jo,Eun-Yeung Gong et al.
Dana Jung et al.
Background: Adoptive cell therapies employing chimeric antigen receptors (CARs) have achieved remarkable success in hematologic malignancies, yet their efficacy in solid tumors remains limited due to the immunosuppressive...
Epitranscriptomic regulation of NVP-BEZ235 resistance in ccRCC via the YTHDF3-SYNM regulatory pathway [0.03%]
透明细胞肾细胞癌中通过YTHDF3-SYNM调节途径表观调控NVP-BEZ235耐药性
Ruiang Wang,Cheng Lu,Erchang Shen et al.
Ruiang Wang et al.
Background: NVP-BEZ235 is a dual PI3K/mTOR inhibitor with promising antitumor activity in clear cell renal cell carcinoma (ccRCC). However, the mechanisms underlying acquired drug resistance remain incompletely defined. ...
Anticancer agent FTY720 upregulates cell cycle regulator BTG2 via the SET/TAF-Iβ -PP2A-SMAD3 signaling pathway and induces G2/M arrest in leukemia [0.03%]
SET/TAF-Iβ-PP2A-SMAD3信号传导途径诱导的BTG2上调在FTY720引起白血病细胞G2期停滞及抗肿瘤活性中的作用
Jieun Park,Yugyeong Kim,Hyebin Park et al.
Jieun Park et al.
UBL4A as a suppressor of intracerebral hemorrhage by binding to MAPK14 and promoting MAPK14 ubiquitination [0.03%]
UBE4A通过与MAPK14结合并促进其泛素化抑制脑出血作用机制研究
Yuyang Ou,Chen Chen,Ziyi Wang et al.
Yuyang Ou et al.
Background: Intracerebral hemorrhage (ICH) is a primary non-traumatic parenchymal hemorrhage of the brain with a high mortality and disability rate. Acupuncture has been proved to alleviate neurological deficits after ICH...
High-quality chromosome-scale genome assembly and adaptive evolution analysis of Yangtze endemic Coreius guichenoti [0.03%]
长江独有拟鲿的高质量染色体级别基因组和适应性进化分析
Jing Chen,Xianqi Peng,Lei Huang et al.
Jing Chen et al.