miR-214-3p inhibits LPS-induced macrophage inflammation and attenuates the progression of dry eye syndrome by regulating ferroptosis in cells [0.03%]
微RNA-214-3p通过调节细胞铁死亡抑制脂多糖诱导的巨噬细胞炎症及延缓干眼病进程
Dandan Zhao,Hao Ji,Weijia Zhang et al.
Dandan Zhao et al.
Background: Dry eye disease (DED) is an ocular illness caused by insufficient tear secretion or poor tear quality, and inflammation is a key factor in its pathogenesis. Previous studies have shown that miRNAs are importan...
Complete chloroplast genomes of three Polygala species and indel marker development for identification of authentic polygalae radix (Polygala tenuifolia) [0.03%]
三种聚花锦鸡儿完全叶绿体基因组和根皮鉴定内真聚花族的插入缺失标记开发
Sumin Jeong,Jong Won Han,Yeseul Kim et al.
Sumin Jeong et al.
Background: In Korea, only Polygala tenuifolia is registered as Polygalae Radix in the pharmacopoeia, while in China, both P. tenuifolia and P. sibirica are used equally. Accurate identification of herbal medicines is cru...
Granzyme mRNA-miRNA interaction and its implication to functional impact [0.03%]
颗粒酶mRNA-miRNA互作及其功能影响
Hyeon-Young Kim,Jung-Min Kim,Young Kee Shin
Hyeon-Young Kim
Background: Granzyme activity can affect the processing and stability of miRNAs within target cells. They also could induce changes in miRNA expression that impact apoptotic signaling. Granzyme-induced apoptosis might res...
A novel ATP2A2 mutation in Darier and genotype phenotype: correlation analysis [0.03%]
ATP2A2的新突变与Darier病的基因型和表型的相关性分析
Xiaofen Guo,Juan Du,Mingwei Lv et al.
Xiaofen Guo et al.
Background: Darier's disease (DD) is a skin disorder caused by mutations in the ATP2A2 gene. Researchers have been investigating the correlation between genotype and phenotype in DD. Understanding the genotype-phenotype r...
Bacterial profile-based body fluid identification using a machine learning approach [0.03%]
基于机器学习的细菌谱体液鉴定方法
Sungmin Kim,Han Chul Lee,Jeong Eun Sim et al.
Sungmin Kim et al.
Background: Identifying the origins of biological traces is critical for the reconstruction of crime scenes in forensic investigations. Traditional methods for body fluid identification rely on chemical, enzymatic, immuno...
Striate palmoplantar keratoderma: a novel DSG1 mutation, combined with an LDLR mutation [0.03%]
掌跖角化病：DSG1的新突变与LDLR突变共存
Li He,Guannan Zhu
Li He
Background: Palmoplantar keratoderma (PPK) is a heterogeneous group of disorders characterized by abnormal thickening of the skin on the palms and soles. Striate palmoplantar keratoderma (SPPK) is commonly caused by heter...
Analysis of key pathways and genes in nodal structure on rat skin surface using gene ontology and KEGG pathway [0.03%]
基于基因本体和KEGG通路的皮肤接触点关键基因与信号通路分析
Joonyoung Shin,A Yeong Park,Suk Ju et al.
Joonyoung Shin et al.
Background: We have previously reported anatomical, histological, and gene expression characteristics of the nodal structure of rat skin surface and suggested its potential as an acupuncture point. However, the specific c...
Enhanced adaptive permutation test with negative binomial distribution in genome-wide omics datasets [0.03%]
基于负二项分布的全基因组Omics数据自适应置换检验的改进方法
Iksoo Huh,Taesung Park
Iksoo Huh
Background: The permutation test has been widely used to provide the p-values of statistical tests when the standard test statistics do not follow parametric null distributions. However, the permutation test may require h...
Impact of potential biomarkers, SNRPE, COX7C, and RPS27, on idiopathic Parkinson's disease [0.03%]
潜在生物标志物SNRPE、COX7C和RPS27对特发性帕金森病的影响
Jaehwan Cheon,Haejin Jung,Byung Yong Kang et al.
Jaehwan Cheon et al.
Background: Parkinson's disease (PD) is a progressive neuro-degenerative disorder most common in older adults which is associated with impairments in movement and other body functions. Most PD cases are classified as idio...
A novel frameshift TBX4 variant in a family with ischio-coxo-podo-patellar syndrome and variable severity [0.03%]
一个新型TBX4框移变异在ischococepodopatell综合征家系中的研究及不同严重程度分析
Giada Moresco,Ornella Rondinone,Alessia Mauri et al.
Giada Moresco et al.
Background: Congenital anomalies of the knee are a spectrum of rare disorders with wide clinical and genetic variability, which are mainly due to the complex processes underlying knee development. Despite progresses in un...