Identification of genetic loci enriched in obese or lean T2D cases in the Korean population [0.03%]
在韩国人群队列中鉴定肥胖或苗条的2型糖尿病病例中的遗传位点
Eun Bi Lim,Yoon Shin Cho
Eun Bi Lim
Background: Obesity causes many complex diseases including type 2 diabetes (T2D). Obesity increases the risk of T2D in Europeans, but there are many non-obese (lean) T2D patients in East Asia. ...
Dual-specificity phosphatase 23 functions as a promising prognostic biomarker in non-small cell lung cancer [0.03%]
双重特异性磷酸酶23作为非小细胞肺癌预后生物标志物的作用
Seula Keum,Yoon Ji Lee,Jung-Woong Kim et al.
Seula Keum et al.
Background: The mechanical remodeling of tumor microenvironment is critical for non-small cell lung cancer (NSCLC) progression. Dual-specificity phosphatase 23 (DUSP23) has been previously identified as a mechano-responsi...
Extracellular nicotinamide phosphoribosyltransferase visfatin activates JAK2-STAT3 pathway in cancer-associated fibroblasts to promote colorectal cancer metastasis [0.03%]
细胞外烟酰胺磷酸核糖转移酶visfatin激活癌相关成纤维细胞中的JAK2-STAT3通路以促进结直肠癌转移
Yun Lei,Dan Shu,Jianyu Xia et al.
Yun Lei et al.
Background: Metastasis is one of the major challenges in the treatment of colorectal cancer (CRC), during which cancer-associated fibroblasts (CAFs) in the tumor microenvironment are critically involved. ...
The diverse landscape of RNA modifications in cancer development and progression [0.03%]
癌症发生发展过程中RNA修饰的多样性景观研究进展
Hyung Seok Kim,Jung Woo Eun,Se Ha Jang et al.
Hyung Seok Kim et al.
Background: RNA modifications, a central aspect of epitranscriptomics, add a regulatory layer to gene expression by modifying RNA function without altering nucleotide sequences. These modifications play vital roles across...
Yixiao Li,Rujin Tian,Dong Wang et al.
Yixiao Li et al.
Background and objective: Argininemia (OMIM: 207800), as well as arginase deficiency, a disorder of the urea cycle caused by deficiency of arginase 1 (ARG1, NP_000036.2), is a scarce autosomal recessive genetic disease. T...
Identification and expression analysis of the SPL gene family during flower bud differentiation in Rhododendron molle [0.03%]
滇灰叶莲花芽分化过程中SPL基因家族的鉴定与表达分析
Dongmei Zhu,Xingmin Geng,Fanyu Zeng et al.
Dongmei Zhu et al.
Background: The family of SQUAMOSA promoter binding protein-like (SPL) transcription factors is essential for regulating plant growth and development. While this SPL gene functional research has been limited in Rhododendr...
Population genetics analysis based on mitochondrial cytochrome c oxidase subunit I (CO1) gene sequences of Cottus koreanus in South Korea [0.03%]
基于韩国岩.ctus koreanus线粒体细胞色素氧化酶亚基I基因序列的群体遗传分析
Bong Han Yun,Yong Hwi Kim,Ho-Seop Han et al.
Bong Han Yun et al.
Background: The freshwater sculpin Cottus koreanus is endemic to the Korean Peninsula and has a fluvial life history. However, its population has been greatly reduced and it is now listed as an endangered class II species...
The facilitated osteogenic differentiation by extracellular proline treatment in in vitro cell cultivation using MC3T3E1 and hPDLF [0.03%]
脯氨酸促进体外成骨细胞分化的研究（MC3T3E1和hPDLF）
Sung-Ho Son,Anna Kim,Je-Hee Jang et al.
Sung-Ho Son et al.
Proline is a major substrate in collagen biosynthesis and is required for collagen molecule formations. However, detailed explanations of the molecular basis through which proline functions in collagen biosynthesis have yet to be provided. ...
Expression profiles of TNF-Alpha and HERV-K Env proteins in multiple types of colon and lung disease [0.03%]
不同类型结肠和肺疾病的TNF-α和HERV-K Env蛋白表达谱分析
Eun-Ji Ko,Jee-Yeong Jeong,Sung Chul Bae et al.
Eun-Ji Ko et al.
Background: Human endogenous retroviruses (HERVs) were integrated into the human genome millions of years ago and have since proliferated to comprise about 8% of the human genome. For a long time, HERVs were thought to be...
A combination of upstream alleles involved in rice heading hastens natural long-day responses [0.03%]
一种水稻开花期上位等位基因的组合加速了其自然长日照反应
Myung-Shin Kim,Joung Sug Kim,Sang Ik Song et al.
Myung-Shin Kim et al.
Background: The female parental line Jinbuol (JBO, early heading) and two recombinant isogenic lines, JSRIL1 and JSRIL2, have been shown to flower 44, 34 and 16 days earlier, respectively, than the male parental line Samg...