E3 ligase MIB1 regulates STAT1/P21 signaling via regulation of FGFR1 in colorectal cancer [0.03%]
E3连接酶MIB1通过调节FGFR1调控STAT1/P21信号通路在结直肠癌中的作用
Chanhee Jung,Jieun Park,Sang Beom Seo
Chanhee Jung
Background: Mind bomb 1 (MIB1) is an E3 ubiquitin ligase that promotes the polyubiquitination-mediated degradation of NOTCH ligands and plays an important role in various cancers by enhancing tumor cell proliferation. Als...
Lactate released by lung adenocarcinoma (LUAD) cells promotes M2 macrophage polarization via the GPR132/cAMP/PKA pathway [0.03%]
肺腺癌细胞释放的乳酸通过GPR132/cAMP/PKA通路促进M2型巨噬细胞极化
Xiao Chen,Zhongzheng Zhang,Kangwu Wang
Xiao Chen
Background: Increasing evidence suggests that lactate is an essential compound in the tumor microenvironment, and especially for macrophage cells. However, the mechanism by which lactate affects macrophages remains unclea...
Analysing glycolysis-related genes reveals the prognostic and diagnostic relevance of IER3 and AGRN in colorectal cancer [0.03%]
分析糖酵解相关基因揭示了IER3和AGRN在结直肠癌预后和诊断中的相关性
Samaneh Dalali,Fatemeh Kaviani,Mohammad Mahdevar et al.
Samaneh Dalali et al.
Background: Colorectal cancer (CRC) is a significant global health issue, with early detection being critical to improving patient survival. Dysregulation of the glycolysis pathway plays a pivotal role in CRC progression,...
CTHRC1 expresses in cancer-associated fibroblasts and is associated with resistance to anti-androgen therapy in prostate cancer [0.03%]
CTHRC1在癌症相关成纤维细胞中表达，并与前列腺癌的抗雄激素治疗抵抗有关
Hai-Qi Liang,Qi-Huan He,Qiu-Ju Wei et al.
Hai-Qi Liang et al.
Background: CTHRC1 overexpresses in prostate cancer and is associated with the proliferation, invasion and migration of prostate cancer cells. However, the roles and mechanisms of CTHRC1 expression in prostate cancer prog...
UBE2C regulating the lung carcinoma progression via inhibiting ubiquitin-proteasomal degradation to increase MMP9 protein stability [0.03%]
UBE2C通过抑制蛋白酶体降解途径增加MMP9蛋白稳定性来促进肺癌进展中的作用研究
Jie Zhao,Juanjuan Dai,Ning Zhou et al.
Jie Zhao et al.
Background: Non-small-cell-lung-cancer (NSCLC) is a prevalent lung malignancy among humans. UBE2C is a critical component of the ubiquitin-proteasome system, and its expression level is significantly associated with cance...
BRN3A, a transcription factor, regulates the expression of genes involved in biological processes shaping the HPV induced cervical cancer [0.03%]
转录因子BRN3A调节基因表达，影响HPV诱导的宫颈癌生物学过程
Anand Prakash,Yashvant Patel,Jagat Kumar Roy
Anand Prakash
Background: Cervical cancer is the fourth most common cancer worldwide in females. This occurs primarily due to the infection of high-risk Human Papilloma Virus (HPV), although in advanced stages it requires support from ...
Correction to: A novel frameshift TBX4 variant in a family with ischio-coxo-podo-patellar syndrome and variable severity [0.03%]
有关于TBX4新型移码变异在ischicoxopodopedal综合征家系中的研究及其不同严重程度的更正通知
Giada Moresco,Ornella Rondinone,Alessia Mauri et al.
Giada Moresco et al.
Published Erratum
Genes & genomics. 2025 Jan 27. DOI:10.1007/s13258-024-01603-w 2025
Transcriptome analysis of wild soybean (Glycine soja) under salt stress and identification of salt-responsive genes [0.03%]
盐胁迫下单基因组模式野大豆(Glycine soja)转录组分析及耐盐相关基因的鉴定
Man Bo Lee,Taekyeom Kim,Dae Yeon Kim et al.
Man Bo Lee et al.
Background: Soil salinity has been a serious threat to agricultural production worldwide, including soybeans. Glycine soja, the wild ancestor of cultivated soybeans, harbors high genetic diversity and possesses attractive...
Comprehensive assessment of the significance of cellular senescence-associated genes in neuroblastoma [0.03%]
全面评估细胞衰老相关基因在神经母细胞瘤中的意义
Yahui Han,Biyun Li,Xiaokun Yu et al.
Yahui Han et al.
Background: The clinical course of high-risk neuroblastoma patients remains suboptimal, and the dynamic and reversible nature of cellular senescence provides an opportunity to develop new therapies. ...
Integrative bioinformatics approaches reveal key hub genes in cyanobacteria: insights from Synechocystis sp. PCC 6803 and Geminocystis sp. NIES-3708 under abiotic stress conditions [0.03%]
整合生物信息学方法揭示了微囊藻在非生物胁迫条件下的关键枢纽基因：源于PCC 6803和NIES-3708中的研究启示
Abbas Karimi-Fard,Abbas Saidi,Masoud Tohidfar et al.
Abbas Karimi-Fard et al.
Background: Cyanobacteria, particularly Synechocystis sp. PCC 6803, serve as model organisms for studying acclimation strategies that enable adaptation to various environmental stresses. Understanding the molecular mechan...