Identification of genetic signatures of positive selection in apes linked to life-history trait adaptations [0.03%]
与生命史特征适应性相关的类人猿基因选择效应鉴定
Yoo-Rim Roh,Kiejung Park,Young Jun An et al.
Yoo-Rim Roh et al.
Background: Apes, including humans, exhibit distinctive life history traits such as increased brain mass, delayed sexual maturity, and extended longevity compared to non-ape primates. These pronounced interspecific differ...
Comprehensive analysis based on IFN-γ and SASP related genes, bulk RNA and single-cell sequencing to evaluate the prognosis and immune landscape of stomach adenocarcinoma [0.03%]
基于IFN-γ和SASP相关基因、Bulk RNA及单细胞测序的全面分析，评估胃腺癌预后及免疫图谱
Jie Yang,Junwei Han
Jie Yang
Background: Stomach adenocarcinoma (STAD) represents the predominant subtype of gastric cancer, known for its drug resistance, unfavorable prognosis, and low cure rates. IFN-γ serves as a cytokine generated by immune cel...
Comparison of unique Dong Tao chickens from Vietnam and Thailand: genetic background and differences for resource management [0.03%]
越南和泰国栋涛鸡的比较：遗传背景与资源管理差异分析
Anh Huynh Luu,Trifan Budi,Worapong Singchat et al.
Anh Huynh Luu et al.
Background: Rare Dong Tao (DT) chickens are a unique and highly productive poultry breed introduced from Vietnam to Thailand ~ 30 years ago. It has a very peculiar appearance, including enormously enlarged feet with reddi...
De novo somatic mosaicisms of INF2 and TRPV4 in patients with Charcot-Marie-Tooth disease [0.03%]
INF2和TRPV4的从头体细胞镶嵌杂合会导致夏科-玛丽- tooth病患者发病
Ah Jin Lee,Sumaira Kanwal,Manisha Awasthi et al.
Ah Jin Lee et al.
Background: Somatic mosaicism is caused by a postzygotic de novo mutation. It is a very rare genetic event, and mosaic cases have been reported only very limitedly among Korean patients with peripheral neuropathies, inclu...
Hippocampal MCT4 as a key regulator in excessive exercise-induced cognitive impairment: involvement of neuroinflammation [0.03%]
海马区MCT4在过度运动致认知损伤中的关键作用及可能的神经炎症机制研究
Min Yeong Lee,Nicole Bon Campomayor,Hee Jin Kim et al.
Min Yeong Lee et al.
Background: As human life expectancy increases, maintaining a healthy lifestyle has become crucial. However, excessive exercise (EE) can lead to negative consequences such as muscle damage and exercise addiction. Recently...
Perillic acid disrupts the specification of germ layers by upregulating the FGF/MAPK pathway [0.03%]
肉豆蔻酸通过上调FGF/MAPK信号通路干扰胚胎细胞三胚层分化 Specification of germ layers is disrupted by perillic acid through upregulation of the FGF/MAPK pathway.
Gang-Ho Yoon,Dong-Seok Park,Myeoung Su Kim et al.
Gang-Ho Yoon et al.
Background: Xenopus embryo is an ideal model for teratogenesis assays to assess the effects of any compounds on the cellular processes crucial for early development and adult tissue homeostasis. ...
The GPR4 antagonist NE 52-QQ57 prevents ox-LDL-induced cellular senescence by promoting the expression of SIRT1 [0.03%]
GPR4拮抗剂NE 52-QQ57通过促进SIRT1表达抑制氧化型低密度脂蛋白诱导的细胞衰老
Wei Luo,Jiming Zhou,Feng Liang et al.
Wei Luo et al.
Background: Cell senescence-associated endothelia dysfunction is a vital point in the pathological progression of atherosclerosis (AS). G-protein coupled receptor 4 (GPR4) is a proton-sensing receptor involved in developi...
Yuman Zhang,Jiali Yang,Yi Gong et al.
Yuman Zhang et al.
Background: Lymph nodes metastasis is the main metastasis mode of tongue squamous cell carcinoma (TSCC). Ras related GTP binding protein B (RalB) have been recently described that it was involved in tumor growth and metas...
Transcriptomic analysis revealed that short-day treatment of seedlings promotes flowering in maize (Zea mays L.) [0.03%]
转录组分析揭示短期光照处理可促进玉米开花
Chunlei Li,Hongquan Mao,Xiaoxue Fan et al.
Chunlei Li et al.
Background: In this study, blockage of transition from vegetative to reproductive growth was observed in short-day maize (Zea mays L.) varieties under long-day conditions. ...
Genome-wide identification of NAC transcription factors in Acer paxii, and their expression dynamics during leaf aging [0.03%]
辽东栎中NAC转录因子的全基因组鉴定及其在叶片衰老过程中的表达动态分析
Yuzhi Fei,Shah Faheem Afzal,Zhu Chen et al.
Yuzhi Fei et al.
Background: The NAC family (consisting of NAM, ATAF1/2, and CUC2) represents a crucial plant-specific transcription factor family, contributing significantly to various aspects of plant growth, development, and reactions ...