Expression profiling of flowering time pathway in the L-ascorbate peroxidase 9 (APX9) near-isogenic line derived from an interspecific cross between Korean Japonica rice (Oryza sativa L.) and Oryza rufipogon [0.03%]
基于韩国 japonica 水稻和 Oryza rufipogon 的衍生近等基因系的开花时间通路表达谱分析
Yun-A Jeon,Hyun-Sook Lee,Cheryl Adeva et al.
Yun-A Jeon et al.
Background: Flowering time (referred to as heading date in rice) is a characteristic controlled by quantitative trait loci (QTLs). Heading date is an important agronomic trait that determines yield in rice and is precisel...
Jaehong Yu,Md Mozaffar Hosain,Taesung Park
Jaehong Yu
Background: Identifying microbiome markers associated with ordered phenotypes, such as disease stages or severity levels, is crucial for understanding disease progression and advancing precision medicine. Despite this imp...
Molecular mechanisms of synovial pathology in osteoarthritis: insights from CXCL10 and MC4R expression [0.03%]
骨关节炎滑膜病理的分子机制：CXCL10和MC4R表达的研究给我们以启示
Tao Yang,Hong Liu,Jian Chen
Tao Yang
Osteoarthritis (OA) is a common progressive joint disorder marked by synovial inflammation, cartilage degeneration, the formation of osteophytes, though its underlying molecular mechanisms remain unclear. This study integrated bioinformatic...
The PAR-score based on PANoptosis genes predicts the progression of ulcerative colitis and the response to anti-TNF-α treatment [0.03%]
基于PANoptosis基因的PAR评分可预测溃疡性结肠炎的发展及抗TNF-α治疗的反应
Yantong Li,Xisheng Yin,Shi Zheng et al.
Yantong Li et al.
Background: Ulcerative colitis (UC), a chronic inflammatory bowel disease, carries an elevated risk of colitis-associated colorectal cancer (CAC). While PANoptosis-a coordinated cell death mechanism integrating pyroptosis...
Association of MSH2, MSH6, and MLH1 polymorphisms with susceptibility and survival in lung cancer patients [0.03%]
MSH2、MSH6和MLH1多态性与肺癌易感性和生存率的关联研究
Jing Cheng,Chao Zuo,Dongli Yang et al.
Jing Cheng et al.
Background: Lung cancer (LC) is the leading cause of cancer-related deaths globally. Genetic variants in mismatch repair (MMR) genes, such as MutS homolog 2 (MSH2), MutS homolog 6 (MSH6) and MutL homolog 1 (MLH1), may inf...
Deep learning-driven whole-slide image analysis predicts chemo-resistance and motility subtypes in muscle-invasive bladder cancer [0.03%]
基于深度学习的全滑动图像分析可预测肌层浸润性膀胱癌的化疗抗性和迁移亚型
Il-San Jeong,Jee-Woo Seo,Seung-Jin Park et al.
Il-San Jeong et al.
Background: Muscle-invasive bladder cancer (MIBC) is a clinically aggressive and heterogeneous disease with variable treatment responses. Transcriptome-based classifications, such as the Chemoresistance-Motility (CrM) sig...
Decoding splicing complexity: integrated genomic analysis reveals two novel pathogenic variants in Chinese dystrophinopathy pedigrees [0.03%]
中国杜氏肌营养不良家系的综合基因组分析揭示两种新型致病突变
Yingwen Liu,Lulu Yan,Yuxin Zhang et al.
Yingwen Liu et al.
Background: Dystrophinopathy is severe X-linked recessive muscle disease caused by mutations in DMD gene. There is an increasing number of deep intronic variants in DMD gene, and understanding the pathogenic mechanisms of...
In-silico matching of SARS-CoV-2 genes and oligonucleotides using the Simple Oligo Matching Tool [0.03%]
基于Simple Oligo Matching Tool的SARS-CoV-2基因与寡核苷酸的计算机匹配分析
Hwan-Min Yu,Sankyu Park,Ha-Eun Shin et al.
Hwan-Min Yu et al.
Sex-specific programming of the gastric and duodenal mitochondrial biogenesis by early-life stress [0.03%]
生命早期应激对胃和十二指肠线粒体生物发生性别特异性编程的影响
Keziban Korkmaz Bayram,Merve Hilal Donmez,Aida Nurul Barokah et al.
Keziban Korkmaz Bayram et al.
Background: Early-life stress (ELS) is a significant risk factor for the development of numerous metabolic and physiological disorders later in life. Obje...
PRDM14 promoted NSCLC cell proliferation, migration and invasion via modulating H3K27me3-mediated PEBP1/Raf-1/MEK/ERK MAPK signaling [0.03%]
PRDM14通过调节H3K27me3介导的PEBP1/Raf-1/MEK/ERK MAPK信号促进非小细胞肺癌细胞增殖、迁移和侵袭
He Shi,Yunfei Jiang,Haijun Mu et al.
He Shi et al.
Background: Our previous research revealed that PRDI-BF1 and RIZ homology domain containing protein 14 (PRDM14) accelerated human non-small cell lung cancer (NSCLC) cell migration. However, the internal mechanism remains ...