The influences of genetic polymorphisms in three candidate genes on the athletic performance of Korean athletes [0.03%]
三个候选基因多态性与韩国运动员运动成绩的影响研究
Jae Koo Lee,Byung Yong Kang
Jae Koo Lee
Backgound: It is known that in addition to environmental factors such as the athlete's own efforts or the qualities of the coach, genetic predisposition can also have a significant impact on achievements in the sports fie...
Single-cell RNA sequencing reveals a putative lncRNA-associated ceRNA network in high-grade serous ovarian cancer [0.03%]
单细胞RNA测序揭示了高级别浆液性卵巢癌中长链非编码RNA相关竞争性内源RNA网络的一项研究
Johyeon Nam,Mi-Ryung Han
Johyeon Nam
Background: High-grade serous ovarian cancer (HGSOC) is the most aggressive ovarian cancer subtype, characterized by high recurrence, chemoresistance, and poor prognosis. Although competing endogenous RNA (ceRNA) networks...
Pathogenicity analysis and functional prediction of a rare LDLR variant in familial hypercholesterolemia combined with Wilson disease [0.03%]
罕见LDLR变异在家族性高胆固醇血症合并威尔森病中的致病性分析及功能预测
Shuxia Huang,Yulan Lu,Yuguo Song
Shuxia Huang
Background: Wilson disease (WD) is a hereditary disorder characterized by abnormal copper metabolism. WD in the liver can result in dyslipidemia, typically manifesting as decreased lipid metabolism. Familial hypercholeste...
Epigenetic regulation of Cereblon in cancer: molecular mechanisms and clinical implications [0.03%]
癌细胞Cereblon表观遗传调控的分子机制及临床意义研究
Joo Mi Yi
Joo Mi Yi
Background: Cereblon (CRBN) serves as the substrate recognition subunit of the CRL4-CRBN E3 ubiquitin ligase complex and isthe primary target of immunomodulatory drugs (IMiDs) in cancer therapy. While CRBN mutations occur...
NPR1 modulates DNA replication in vascular endothelial cells via the transcription factor E2F2 [0.03%]
NPR1通过转录因子E2F2调节血管内皮细胞DNA复制
Fengqing Zhang,Hong Tang,Xiaocheng Mao et al.
Fengqing Zhang et al.
Background: Natriuretic peptide receptor 1 (NPR1) plays a crucial role in maintaining the functionality of vascular endothelial cells. However, its role in regulating DNA replication and genome stability in endothelial ce...
Multi-omics profiling uncovers LINC00486-associated lncRNA regulation in human traumatic brain injury [0.03%]
多组学谱分析揭示LINC00486相关长链非编码RNA在人脑创伤中的作用
Tala Al-Rubaye,Zenab Isa,Doga Erenkol et al.
Tala Al-Rubaye et al.
Background: Traumatic brain injury (TBI) induces broad molecular changes in the human brain, altering gene expression in diverse neural and glial cells. While the transcriptional effects of TBI on protein-coding genes are...
PSM-SMOTE: propensity score matching and synthetic minority oversampling for handling unbalanced microbiome data [0.03%]
PSM-SMOTE：使用倾向分数匹配和合成少数过采样处理不平衡的微生物组数据
Jeongsup Moon,Zhe Liu,Taesung Park
Jeongsup Moon
Background: Predictive models using microbiome data often suffer from covariate imbalance and class imbalance, biasing results. Propensity Score Matching (PSM) balances covariates but reduces sample size, while borderline...
A prognostic model for basal-like breast cancer based on beta-alanine metabolism genes: EHHADH as a potential biomarker and target for drug screening [0.03%]
基于β-丙氨酸代谢基因的basal-like乳腺癌预后模型：EHHADH作为潜在生物标志物和药物筛选靶点
Xianjie Cheng,Birong Liu,Hong Lou et al.
Xianjie Cheng et al.
Background: The high heterogeneity of basal-like breast cancer (BLBC) impedes early diagnosis and accurate prognosis. Beta-alanine, a non-essential amino acid involved in various metabolic pathways, accumulates in BLBC ce...
Jeong Woen Shin,Bo-Mi Kim,Jun Kim et al.
Jeong Woen Shin et al.
Background: Polypterus senegalus is a major actinopterygian fish that provides vital insights into vertebrate terrestrial adaptation. Advances in sequencing technologies have enabled improvements to the reference genome o...
Emerging technologies and clinical translation of urine-based liquid biopsy in urological cancers [0.03%]
基于尿液的液体活检在泌尿系统肿瘤临床转化中的新兴技术及应用
Seo-Yeong Yoon,Gi-Eun Yang,Jong-Kil Nam et al.
Seo-Yeong Yoon et al.
Urine-based liquid biopsy represents a transformative, non-invasive diagnostic approach that enables the molecular profiling of tumor-derived biomarkers shed into the urinary tract. By overcoming the limitations of traditional tissue biopsi...