Osteoblast-derived osteomodulin restrains osteoclastogenesis via ITGB8/RRM2-mediated reduction of mitochondrial respiration and mitochondrial ATP production [0.03%]
成骨细胞来源的软骨糖蛋白-3调控破骨细胞生成的新机制研究：通过ITGB8/RRM2介导减少线粒体呼吸和ATP生成
Xiaowen Jiang,Han Chen,Weiduo Hou et al.
Xiaowen Jiang et al.
Osteoporosis is driven in part by excessive osteoclast-mediated bone resorption, yet osteoblast-derived extracellular cues that restrain osteoclast bioenergetics remain incompletely defined. Here we identify osteomodulin (OMD), a matrix-ass...
COL1A1-induced LOXL2 promotes ovarian cancer metastasis via a feedback loop upon inhibiting EGFR lysosomal degradation [0.03%]
COL1A1通过抑制EGFR溶酶体降解诱导LOXL2促进卵巢癌转移的反馈回路
Zhangjin Shen,Lingkai Gu,Mengxia Zheng et al.
Zhangjin Shen et al.
Widespread peritoneal metastasis is a key reason for high mortality in ovarian cancer and understanding its mechanisms will offer new targets for the effective treatment of metastatic ovarian cancer. Our previous research revealed that coll...
Retraction Note: PAX8-AS1 knockdown facilitates cell growth and inactivates autophagy in osteoblasts via the miR-1252-5p/GNB1 axis in osteoporosis [0.03%]
撤回 notice:通过miR-1252-5p / GNB1轴敲除PAX8-AS1可促进骨质疏松症中破骨细胞生长并激活自噬
Caiqiang Huang,Runguang Li,Changsheng Yang et al.
Caiqiang Huang et al.
Efficient generation of human dorsal spinal GABAergic progenitors for the treatment of spinal cord injury [0.03%]
高效生成人背侧脊髓GABA能前体细胞治疗脊髓损伤
Xianglan Feng,Yutong Wan,Minxian Peng et al.
Xianglan Feng et al.
Traumatic spinal cord injury (SCI) induces rapid necrotic cell death, leading to severe neuronal and glial loss. A critical consequence is the disruption of γ-aminobutyric acid (GABA)ergic inhibitory tone in the dorsal horn, which results ...
HMGCS2-dependent β-OHB/H3K9bhb ameliorates synaptic plasticity and cognition in Alzheimer's disease [0.03%]
HMGCSD2依赖的β-羟基丁酸/组蛋白H3赖氨酸9丁酸盐改善阿尔茨海默病中的突触可塑性和认知能力
Haitao Yu,Fangzhou Wang,Jia-Qi Yuan et al.
Haitao Yu et al.
Ketogenic diet (KD) can significantly ameliorate cognition in Alzheimer's disease (AD), but the specific mechanism is not clear. Histone3-lysine9-β-hydroxybutyrylation (H3k9bhb), a novel histone modification mark induced by ketogenesis-gen...
Proline/serine-rich coiled-coil 1 alleviates atherosclerosis via remodeling tryptophan metabolism mediated by Akkermansia muciniphila [0.03%]
脯氨酸/丝氨酸丰富型卷曲螺旋蛋白1通过调节Akkermansia muciniphila介导的色氨酸代谢缓解动脉粥样硬化
Qiao Wu,Kexin Hu,Qianqian Wang et al.
Qiao Wu et al.
Genome-wide association studies have implicated proline/serine-rich coiled-coil 1 (PSRC1) in coronary artery disease (CAD) pathogenesis. Our previous studies demonstrated that Psrc1 deficiency accelerates atherosclerosis via gut microbial d...
DNA methyltransferase inhibition is a therapeutic vulnerability in VHL-deficient renal cell carcinoma cells [0.03%]
VHL缺陷的肾细胞癌细胞中DNA甲基转移酶抑制是治疗弱点
Yue Pu,Ziruoyu Wang,Shishi Tao et al.
Yue Pu et al.
von Hippel-Lindau (VHL) is a tumor suppressor frequently inactivated in renal cell carcinoma (RCC), and its loss is associated with aberrant DNA methylation. Here we demonstrate that VHL-deficient RCC cells are highly vulnerable to DNA meth...
Structural insights into disease-associated mutations in the microRNA processing machinery [0.03%]
微小核糖核酸加工装置中与疾病相关的突变的结构见解
Hansol Lee,Jaehyun Lee,Soung-Hun Roh
Hansol Lee
MicroRNAs (miRNAs) are small noncoding RNAs that mediate post-transcriptional gene silencing through a conserved pathway involving the sequential actions of DROSHA, DICER and Argonaute proteins. These RNA interference core components recogn...
Local delivery of OSK factors enables partial cellular reprogramming to mitigate osteoarthritis and cartilage fibrosis [0.03%]
局部递送OSK因子使细胞部分重编程可缓解骨关节炎和软骨纤维化
Yi-Wei Liu,Jing-Tao Zou,Jiang-Shan Gong et al.
Yi-Wei Liu et al.
Osteoarthritis (OA) is a prevalent joint disease with a complex etiology, involving epigenetic alterations. Recent studies have suggested the potential of Oct4, Sox2 and Klf4 (OSK) in rejuvenating adult cells and facilitating tissue repair,...
Gut microbiota modulation of epigenetic target EHMT2: Lacticaseibacillus rhamnosus Fb7-311 regulated renal cell carcinoma apoptosis and metastasis [0.03%]
肠道微生物群调节表观遗传靶标EHMT2：Lacticaseibacillus rhamnosus Fb7-311调控肾细胞癌凋亡及转移
Jeongmin Lee,Jinkwon Lee,In Hwan Tae et al.
Jeongmin Lee et al.
Renal cell carcinoma (RCC), also known as renal cell cancer or renal cell adenocarcinoma, is the most common type of kidney cancer and a common malignant tumor of the urinary system. Although surgical interventions and cancer treatments suc...