Contrasting Effects of the Neuropeptides Substance P, Somatostatin, and Neuropeptide Y on the Methamphetamine-Induced Production of Striatal Nitric Oxide in Mice [0.03%]
神经肽P物质、生长抑素和神经肽Y对甲基苯丙胺致小鼠纹状体一氧化氮产生的不同影响
Lauriaselle Afanador,Haley Yarosh,Jing Wang et al.
Lauriaselle Afanador et al.
Several laboratories have shown that methamphetamine (METH) neurotoxicity is associated with increases of nitric oxide (NO) production in striatal tissue and blockade of NO production protects from METH. Because substance P modulates NO pro...
Effects of the abused inhalant toluene on the mesolimbic dopamine system [0.03%]
苯乙烯吸入滥用对中脑边缘多巴胺系统的影响
John J Woodward,Jacob Beckley
John J Woodward
Toluene is a representative member of a class of inhaled solvents that are voluntarily used by adolescents and adults for their euphorigenic effects. Research into the mechanisms of action of inhaled solvents has lagged behind that of other...
Review of toluene action: clinical evidence, animal studies and molecular targets [0.03%]
甲苯作用的评述:临床证据、动物实验及分子靶点分析
Silvia L Cruz,María Teresa Rivera-García,John J Woodward
Silvia L Cruz
It has long been known that individuals will engage in voluntary inhalation of volatile solvents for their rewarding effects. However, research into the neurobiology of these agents has lagged behind that of more commonly used drugs of abus...
Nicotine Blocks the Depressogenic Effects of Alcohol: Implications for Drinking-Smoking Co-Morbidity [0.03%]
尼古丁阻断酒精的致抑郁作用：对饮酒吸烟共病的意义
Olubukola Kalejaiye,Babur H Bhatti,Robert E Taylor et al.
Olubukola Kalejaiye et al.
Alcohol and nicotine are two very commonly abused legal substances. Although various hypotheses for such co-dependence have been suggested, it is not known whether the effects of alcohol and nicotine on mood behavior may also contribute to ...
Pharmacological classification of the abuse-related discriminative stimulus effects of trichloroethylene vapor [0.03%]
三氯乙烯蒸汽的滥用相关判别刺激效应的药理学分类
Keith L Shelton,Katherine L Nicholson
Keith L Shelton
Inhalants are distinguished as a class primarily based upon a shared route of administration. Grouping inhalants according to their abuse-related in vivo pharmacological effects using the drug discrimination procedure has the potential to p...
Inhibition of Protein kinase Mzeta (PKMζ) in the mesolimbic system alters cocaine sensitization in rats [0.03%]
蛋白激酶Mζ(PKMζ)在中脑边缘系统中的抑制作用可改变大鼠对可卡因的敏感性
María E Vélez-Hernández,Rafael Vázquez-Torres,Maria C Velasquez-Martinez et al.
María E Vélez-Hernández et al.
Chronic cocaine use produces long-lasting changes in reward circuits that may underlie the transition from casual to compulsive patterns of drug use. Although strong neuroadaptations within the mesocorticolimbic system are known to occur, t...
Intraperitoneal Administration of CART 55-102 Inhibits Psychostimulant-Induced Locomotion [0.03%]
CART 55-102 腹腔给药抑制兴奋剂诱导的运动行为
Martin O Job,Michael J Kuhar
Martin O Job
CART (cocaine and amphetamine regulated transcript) peptide functions as both a neurotransmitter and a hormone and is found both in the central nervous system (CNS) and in the periphery. CART peptide in the nucleus accumbens (NAc) has been ...