Chronic Methamphetamine Causes Differential Expression of Immediate Early Genes in the Nucleus Accumbens and Midbrain of Rats [0.03%]
慢性甲基苯丙胺引起大鼠伏核和中脑瞬时早期基因差异表达
Tiffany Garrett,Ingrid Tulloch,Michael T McCoy et al.
Tiffany Garrett et al.
The present study investigated whether chronic methamphetamine (METH) would suppress METH-induced mRNA expression of immediate early genes (IEGs) in the rat brain. Rats were given METH or saline over two weeks. After an overnight withdrawal...
Temporal Requirement for the Protective Effect of Dietary Cholesterol against Alcohol-Induced Vasoconstriction [0.03%]
膳食胆固醇对酒精引起血管收缩的保护作用所需的时间条件
Olga Seleverstov,Kelsey North,Maria Simakova et al.
Olga Seleverstov et al.
Moderate-to-heavy episodic alcohol drinking resulting in 30-80 mM of ethanol in blood constricts cerebral arteries and constitutes a risk factor for cerebrovascular disease. Alcohol-induced constriction of cerebral arteries in vivo and ex v...
Wenfei Huang,Erika P Penaherrera,Danaika F Desir et al.
Wenfei Huang et al.
Alcohol is the most widely used addictive substance. Severe alcohol abuse is diagnosed as "alcohol use disorder" (AUD). A common and harmful drinking pattern is binge drinking that elevates a person's blood alcohol concentration to ≥ 0.08%...
Gestational Age-Dependent Interplay between Endocannabinoid Receptors and Alcohol in Fetal Cerebral Arteries [0.03%]
妊娠期大麻素受体与酒精对胎儿大脑动脉的年龄依赖性交互作用
Maria Simakova,Ana Tobiasz,Ryan D Sullivan et al.
Maria Simakova et al.
Alcohol (ethanol) is one of the most widely consumed drugs. Alcohol consumption by pregnant women may result in a range of fetal abnormalities termed fetal alcohol spectrum disorders (FASDs). The cerebrovascular system is emerging as a crit...
Both Ketamine and NBQX Attenuate Alcohol-Withdrawal Induced Depression in Male Rats [0.03%]
氯胺酮和NBQX能缓解雄性大鼠酒精戒断诱导的抑郁行为
Bruk Getachew,Yousef Tizabi
Bruk Getachew
The co-morbidity between heavy drinking and depression can negatively influence successful cessation of alcohol use. Since ketamine, a glutamatergic NMDA receptor antagonist, has shown promise as a quick-acting antidepressant, we studied it...
Alcohol-Induced Hepatic Steatosis: A Comparative Study to Identify Possible Indicator(s) of Alcoholic Fatty Liver Disease [0.03%]
酒精性肝脂肪变：一项识别酒精性脂肪肝病可能指标的比较研究
Harshica Fernando,Kamlesh K Bhopale,Shakuntala S Kondraganti et al.
Harshica Fernando et al.
Background: Fatty liver is an early sign of both nonalcoholic and alcoholic fatty liver diseases. Ethanol feeding using a Lieber-DeCarli liquid diet (LD) model which contains 35% fat to rats or mice is a well-established ...
Prenatal Alcohol Exposure, Anesthesia, and Fetal Loss in Baboon Model of Pregnancy [0.03%]
孕期酒精暴露、麻醉和妊娠流产的恒河猴模型研究
Kelsey North,Ana Tobiasz,Ryan D Sullivan et al.
Kelsey North et al.
Approximately half of pregnant women engage in alcohol consumption some time during pregnancy. On the other hand, a small percentage of pregnant women undergo surgery and anesthesia at some time during pregnancy. In emergencies, anesthesia ...
Alcohol-Induced Increases in Inflammatory Cytokines Are Attenuated by Nicotine in Region-Selective Manner in Male Rats [0.03%]
尼古丁可区域特异性削弱酒精诱导的促炎细胞因子增加（雄性大鼠模型）
Olubukola Kalejaiye,Bruk Getachew,Clifford L Ferguson et al.
Olubukola Kalejaiye et al.
Background: Heavy use of alcohol is commonly associated with heavy smoking (nicotine intake). Although many factors, including mood effects of these two drugs may contribute to their co-use, the exact neurobiological unde...
Ketamine Differentially Attenuates Alcohol Intake in Male Versus Female Alcohol Preferring (P) Rats [0.03%]
氯胺酮通过不同机制抑制酒精依赖的雄性和雌性P系系大鼠饮酒行为的研究差异性研究
Amir H Rezvani,Edward D Levin,Marty Cauley et al.
Amir H Rezvani et al.
Background: Although various pharmacological tools in combating addiction to alcohol are available, their efficacy is limited. Hence, there is a critical need for development of more effective medications. Recent advances...
Age-Dependent Susceptibility to Alcohol-Induced Cerebral Artery Constriction [0.03%]
酒精诱导的脑血管收缩与年龄有关的易感性研究
Anna N Bukiya,Olga Seleverstov,Shivantika Bisen et al.
Anna N Bukiya et al.
Background: Age has been recognized as an important contributor into susceptibility to alcohol-driven pathology. Purpose: We aimed at d...