Structure-based screening and molecular dynamics of phytophytochemicals against pseudomonas aeruginosa quorum sensing systems [0.03%]
基于结构的植物化学物质筛选及对铜绿假单胞菌群体感应系统的分子动力学研究
Sinethemba H Yakobi,Uchechukwu U Nwodo
Sinethemba H Yakobi
Pseudomonas aeruginosa employs quorum sensing (QS) to regulate virulence and antibiotic resistance, making QS inhibition a promising anti-infective strategy. Here, we computationally evaluated three phytochemicals-baicalin, berberine, and c...
Cloning and expression of outer membrane proteins from Vibrio alginolyticus, and evaluation of their immune response in Epinephelus coioides [0.03%]
副溶血性弧菌外膜蛋白的克隆表达及其在真鲷体内的免疫应答评价
Ngo Thi Huyen,Dong Van Quyen,Tran Nhu Quynh et al.
Ngo Thi Huyen et al.
Vibrio alginolyticus and Vibrio parahaemolyticus pose significant threats to various marine fish species, with mortality rates reaching as high as 90 %. Outer membrane proteins represent promising antigens for creating immune responses. The...
Investigating the potential anti-cancer mechanism for thyroid cancer: Role of Herba Epimedii via network pharmacology approach [0.03%]
基于网络药理学方法探究淫羊藿治疗甲状腺癌的潜在机制研究
Xuehan Wang,Lin Guo,Yiren Feng et al.
Xuehan Wang et al.
Objective: To investigate the effective ingredients, crucial molecular targets, and the underlying molecular mechanisms associated with Herba Epimedii (HE) that exhibits anti-cancer effects for treating thyroid cancer (TC...
Eco-friendly synthesis of silver nanoparticles from the leaf blades extract of seagrass Thalassia hemprichii: Multifunctional agents for biomedical and environmental applications [0.03%]
从海洋植物海狐尾藻叶片中提取银纳米颗粒的环保型合成方法及其在生物医学和环境应用中的多功能性研究
Shibin Eranhottu,Tijo Cherian,R Mohanraju et al.
Shibin Eranhottu et al.
The current study reports for the first time the synthesis of environmentally friendly silver nanoparticles (AgNPs) using leaf blades extract (THE) of seagrass Thalassia hemprichii. The AgNPs were described using several spectroscopic metho...
Bioinformatics and experimental validation of MAPK pathway activation in diabetic kidney disease induced by glucose variability [0.03%]
生物信息学和实验验证血糖波动诱导的糖尿病肾脏疾病中MAPK通路的激活
Sujuan Li,Huijuan Wang,Yuanhang Zhang
Sujuan Li
Objective: This article aims to evaluate the role of factors associated with oxidative stress induction in fluctuating hyperglycemia-induced diabetic kidney disease (DKD) and to elucidate the molecular mechanisms underlyi...
Efficient and cost-effective shoot regeneration in Aguaymanto (Physalis peruviana L.) using meta-Topolin and 6-benzylaminopurine combinations [0.03%]
高效经济的金印葡萄(Physalis peruviana L.)再生芽培养体系的建立
Raúl Vargas,Carmen N Vigo,Marly Guelac et al.
Raúl Vargas et al.
Physalis peruviana L. (known as aguaymanto or goldenberry) is a high-value Andean fruit crop with growing international demand due to its nutritional and nutraceutical properties. However, the development of advanced biotechnological tools ...
PABPC1 expression in papillary renal cell carcinoma and its significance for survival outcomes [0.03%]
PABPC1在乳头状肾细胞癌中的表达及其对预后的影响
Cheng Huang,Aichun Long,Tianyun Li et al.
Cheng Huang et al.
Objective: This study examines the expression pattern and prognostic relevance of PABPC1 in papillary renal cell carcinoma (pRCC) to evaluate its potential as a clinical outcome biomarker. ...
Elucidating the functional significance of catalytic and chitin-binding domains for the anti-cancer property of a bacterial endochitinase [0.03%]
阐明催化和几丁质结合结构域对细菌内源性几丁质酶抗癌特性功能的意义
Ankita Shrivastava,Manik Goel,Md Fahim Khalid et al.
Ankita Shrivastava et al.
Chitinases are enzymes that facilitate the breakdown of chitin and also interact with carbohydrate moieties such as heparin sulphate due to structural similarity with chitin, thereby influencing cell adherence and migration. Bacterial endo-...
Exploring the potential of Bacillus spp. for secondary metabolite production through genome mining approaches [0.03%]
通过基因组采矿方法探索Bacillus属细菌产生次级代谢产物的潜力
Showti Raheel Naser,Sanjana Fatema Chowdhury,Md Murshed Hasan Sarkar et al.
Showti Raheel Naser et al.
With the rise of antibiotic resistance along with the increase in the emergence of infectious diseases, the search for new therapeutic agents is of dire need. Bacillus is one of the widely distributed genera of bacteria, which has immense a...
Expression and interaction of RNA binding protein HuR with multidrug transporters (P-GP, MRP1, and ABCG2) in chemoresistant breast and colorectal cancer cells [0.03%]
RNA结合蛋白HuR与多药耐药转运体(P-糖蛋白、MRP1和ABCG2)在化学抗性乳腺癌和结直肠癌细胞中的表达及其相互作用
Sudipta Deb Nath,Md Mahmudul Hasan Akash,Md Tamzid Hossain Tanim et al.
Sudipta Deb Nath et al.
Background: Chemoresistance poses a significant challenge in cancer treatment. Over expression of efflux pumps is one of the primary mechanisms that confer chemoresistance. P-GP, MRP1, and ABCG2, which are important ABC e...