Uncovering evolutionary and phylogenetic relationships in Glyptothorax species through comparative mitochondrial genomics [0.03%]
Somasundaram Iyyappan,Suvadip Ghara,Irfan Ahmad Bhat et al.
Somasundaram Iyyappan et al.
The mitochondrial genome serves as a crucial molecular marker for studying phylogenetic relationships and molecular evolution in fish. Despite their ecological significance in freshwater ecosystems, Glyptothorax fishes have limited evolutio...
Unraveling the influence of TGF-β rs9282871 and miRNA let-7c relative expression on TGF-β production in hepatocellular carcinoma patients [0.03%]
Sally Farouk,Maha M Elbrashy,Ahmed Khairy et al.
Sally Farouk et al.
Hepatocellular carcinoma (HCC) is ranked globally as the second most common cancer-related death. Transforming growth factor beta (TGF-β) plays a dual role in HCC. Meanwhile, miR-let-7c has been identified as a tumor suppressor microRNA th...
Identification of potential key genes and molecular mechanisms of oral squamous cell carcinoma based on integrated bioinformatics approach [0.03%]
Mohammad Khursheed Alam,Md Rakibul Islam,Tahsinul Haque et al.
Mohammad Khursheed Alam et al.
Oral Squamous Cell Carcinoma (OSCC) is one of the most occurred cancer types with yearly 377,713 cases and 177,000 deaths. Traditional risk factors of OSCC include smoking, alcohol consumption, excessive sun exposure, family history of canc...
Enhancing clinical insights in glioma grading using Bayesian Optimization and Explainable AI [0.03%]
Alaa M Elsayad,Omar A Elsayad
Alaa M Elsayad
Accurate glioma grading is paramount for guiding treatment strategies and predicting patient prognosis. This study introduces a novel and clinically relevant framework for glioma grade classification, specifically distinguishing between low...
Genetic underpinnings of type-2 diabetes (T2D) with colorectal cancer (CRC): In-silico discovery of common molecular signatures, pathogenetic processes and therapeutic candidates [0.03%]
Reaz Ahmmed,Umme Samia Antu,Tasfia Noor et al.
Reaz Ahmmed et al.
Type-2 diabetes (T2D) is a risk factor for colorectal cancer (CRC) and the incidence rate of CRC in T2D patients is significantly higher than in control patients. It may be associated with the overlapping dysregulated genetic factors. The m...
Surface-bioengineering of bacteriophage AP205 and MS2 virus-like particles with novel Spytag003 for antigen conjugation [0.03%]
Hong Liu,Ebenezer Tumban
Hong Liu
The insertion of foreign antigens on the coat protein of viruses sometimes interferes with the ability of the coat proteins to assemble into virus-like particles (VLPs). To overcome this limitation, Spytag/Spycatcher bio-conjugation system ...
Propolis alleviates brain tissue damage and oxidative abnormalities in streptozotocin (STZ)-induced diabetes [0.03%]
Ahmed M Ashour
Ahmed M Ashour
Background: Diabetes is a serious and rapidly growing global health issue that can affect many organs, including the brain. It is often linked to complications such as cardiovascular disease and cerebral ischemia. Propoli...
Dual targeting of IGF-1R and K-RAS with natural phytochemicals for lung cancer therapy: an in-silico study [0.03%]
Sk Faisal Ahmed,Zubaer Hossen,Indira Chakraborty et al.
Sk Faisal Ahmed et al.
Lung cancer remains one of the leading causes of cancer-related mortality worldwide, and the limitations and adverse effects of conventional chemotherapy necessitate the exploration of alternative therapeutic strategies. In this study, we u...
Morpho-molecular diversity of improved Indonesia's rice varieties based on grain morphology and three types of DNA-based markers [0.03%]
Reflinur Reflinur,Adin Heriyan Nugroho,Zidni Muflikhati et al.
Reflinur Reflinur et al.
Genetic improvement of rice (Oryza sativa L.) requires a clear understanding of both phenotypic and molecular diversity. This study examined 82 improved Indonesian rice varieties using grain morphological traits and three DNA-based marker s...
Structural analysis of clingstone and freestone peach (Prunus persica L.) plastome genome: provides insight into phylogeny and time diversification [0.03%]
Mokhtar Said Rizk,Alsamman M Alsamman,Heba A M AbdAlla et al.
Mokhtar Said Rizk et al.
Background: The complete plastome genome of peach represents a valuable genomic resource for elucidating the evolutionary history and phylogenetic relationships within Prunus species. ...