Comparative evaluation of E. coli expression systems for soluble hScFv-IL-17A with an unpaired CDR-L3 cysteine [0.03%]
含有未配对CDR-L3半胱氨酸的hScFv-IL-17A可溶表达工程菌株的构建及鉴定
Weeraya Thongkum,Kanokporn Sornsuwan,Thanathat Pamonsupornwichit et al.
Weeraya Thongkum et al.
This study systematically evaluated Escherichia coli (E. coli) expression systems for the production of a humanized single-chain variable fragment targeting interleukin-17A (hScFv-IL-17A). A wild-type hScFv (hScFv-IL-17A-WT), derived from S...
Identification of novel Menin-MLL interaction inhibitors targeting leukemia using in-silico virtual screening and structure-based drug design approaches [0.03%]
基于计算的虚拟筛选和结构为基础的药物设计方法识别新的Menin-MLL相互作用抑制剂以治疗白血病
Amany I Almars,Shahad W Kattan
Amany I Almars
Leukemogenesis fundamentally depends on the interaction between Menin and MLL1 fusion proteins, especially in the context of aggressive mixed-lineage leukemia (MLL)-rearranged subtypes. This interaction can be disrupted to facilitate a focu...
Therapeutic potential of Xylocarpus granatum bark extracts: antioxidant, anti-inflammatory, cytotoxic and molecular insights [0.03%]
Xylocarpus granatum树皮提取物的治疗潜力：抗氧化、抗炎、细胞毒性和分子见解
Nur-Nahar,Md Ekramul Islam,Mst Jannatul Mewa et al.
Nur-Nahar et al.
Free radicals contribute to various diseases, while antioxidants, like phenolic compounds and flavonoids, counteract their effects. This study examines the antioxidant, anti-inflammatory, and cytotoxic properties of Xylocarpus granatum bark...
The effects of gut microbiota-derived short-chain fatty acids (SCFAs) on human colon cancer cells: An in vitro study [0.03%]
肠道微生物群衍生的短链脂肪酸（SCFA）对人类结肠癌细胞的影响：一项体外研究
Shiva Darabi,Fatemeh Keshavarzi,Parviz Ashtari et al.
Shiva Darabi et al.
Colorectal cancer (CRC) has always been a major concern for researchers due to its deadly nature. One of the microbial metabolites found in the gut is short-chain fatty acids (SCFAs), which have the ability to regulate the immune system and...
Detection method for CRISPR-Cas9 edited tomato with single nucleotide deletion using multiplex probe-based real-time PCR and confirmation of non-transgenicity: A case study [0.03%]
利用多重探针实时荧光定量PCR方法检测CRISPR-Cas9编辑的番茄中单碱基缺失事件并确认非转基因状态：个案研究
Monika Singh,Shiwani,Raghavendra Aminedi et al.
Monika Singh et al.
The adoption of gene-edited (GE) food crops has increased due to applicability of technology without drastically affecting the genetic information. However, the discussion on regulatory regime pertaining to GE plants throughout the globe is...
Integrative multi-omics analysis identifies genetically supported druggable targets for inflammatory bowel disease [0.03%]
整合多组学分析发现了炎症性肠病的遗传支持的可药物作用靶点
Si-Chun Gu,Si-Lu Zeng,Wei Zhang et al.
Si-Chun Gu et al.
Background: Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), represents a set of chronic, immune-mediated gastrointestinal disorders with increasing global prevalence. Curre...
Genetic diversity and population structure of sour passion fruit in Brazil [0.03%]
巴西酸西番莲的遗传多样性和群体结构
Carolina Sampaio Araponga,Gonçalo Santos Silva,Cláusio Antônio Ferreira de Melo et al.
Carolina Sampaio Araponga et al.
Sour passion fruit (Passiflora edulis) is the most economically important species in the genus Passiflora, mainly due to its edible fruit. Genetic diversity and population structure were analyzed in five P. edulis populations, each comprisi...
Chinmay Hazare,Prashant Bhagwat,Suren Singh et al.
Chinmay Hazare et al.
Fibrinolytic enzymes are proteolytic enzymes that degrade fibrin clots. They play a significant role in managing thrombosis as they are crucial for the lysis of the clot. Despite the importance and extensive research on fibrinolytic enzymes...
Within-family analysis of PRS313: insights into breast cancer risk prediction [0.03%]
家谱内分析PRS313：深入了解乳腺癌风险预测的见解
Hossein Lanjanian,Sahand Tehrani Fateh,Mahdi Akbarzadeh et al.
Hossein Lanjanian et al.
Polygenic risk scores (PRS) incorporate numerous genetic variants, each with a small impact on cancer pathogenesis, to provide personalized risk assessments. This study investigated, the applicability of PRS313 for breast cancer risk both i...
Molecular Detection of natural bacterial flora within Culex pipiens pipiens (Diptera: Culicidae) in Aleppo, Syria [0.03%]
叙利亚阿勒颇白纹伊蚊自然菌群的分子检测
Ahmed Allahem,Reem Alajmi,Mais Alzarzor Alajami et al.
Ahmed Allahem et al.
Culex pipiens complex members have been known as important vectors of medical and veterinary arthropod-borne diseases for many pathogens (viral, bacterial, parasitic). Therefore, this study aimed to investigate natural bacterial flora withi...