Full genome sequences of two strains of Pseudomonas stutzeri isolated from oil reservoirs and their adaptation mechanisms to harsh environments [0.03%]
两株油田分离施氏假单胞菌全基因组序列及极端环境适应机制分析
Qijun Wu,Sanbao Su,Yuxiao Han et al.
Qijun Wu et al.
Pseudomonas stutzeri is a type of microorganism widely present in nature, particularly in petroleum-contaminated environments, where it exhibits a high capacity for biodegradation. In this study, two strains of Pseudomonas stutzeri 1W1-1A a...
Katsuyoshi Kumagai,Ayumi Chiba,Hiroaki Yajima
Katsuyoshi Kumagai
Recent advances in design biology, including artificial cells, DNA nanostructures, artificial intelligence (AI)-driven molecular design, biofoundries, and next-generation genome editing, are transforming the health sciences of mind and body...
Hub genes and common pathogenic mechanisms between COPD and H. pylori infection [0.03%]
慢性阻塞性肺疾病和幽门螺旋杆菌感染的汇合基因及共同致病机制
Keying Li,Tuliang Liang,Minfang Li et al.
Keying Li et al.
Background: Chronic obstructive pulmonary disease (COPD) andHelicobacter pylori (H. pylori) infection may share common pathogenic mechanisms, yet their molecular and cellular interactions remain poorly defined. ...
Bioinformatics-driven identification of pathogenic missense nsSNPs in the human proto-oncogene SRC and cancer susceptibility [0.03%]
生物信息驱动的人类原癌基因SRC致病性错义nsSNPs的鉴定及与癌症易感性的关联分析
Md Shakil Ahamed,Roksana Khanam,K M Tanjida Islam et al.
Md Shakil Ahamed et al.
SRC is a proto-oncogene that regulates cell proliferation and survival, and its dysregulation is commonly observed in diverse cancers. While SRC kinase dysregulation is well-established as a cancer driver, the functional consequences of its...
DeepBovC2H2-ZF: deep learning-guided prediction and molecular dynamics validation of C2H2 zinc finger transcription factors in Bovidae [0.03%]
深部牛C2H2-ZF：深度学习引导的牛科C2H2锌指转录因子的预测及分子动力学验证
Bharati Pandey,Manbir Singh
Bharati Pandey
C2H2 zinc finger (ZF) transcription factors (TFs) are among the most abundant and versatile regulatory proteins, playing critical roles in development, differentiation, apoptosis, stress response, and immune regulation. In livestock, especi...
Enhanced carotenoid accumulation in Chloroccocum humicola under controlled CO2 and light conditions [0.03%]
在控CO2和光照条件下Chloroccocum humicola中类胡萝卜素的积累增强
Chatchai Kunyawut,Idtisak Paopo,Chakkrit Umpuch
Chatchai Kunyawut
Carotenoids are potent antioxidants and high-value bioactive compounds that green microalgae can efficiently synthesize. This study aimed to enhance carotenoid production in Chlorococcum humicola TISTR 8551 using a two-stage cultivation str...
Quercetin-liposomes effectively regulated the Nrf2/Keap1 and NF-κB/P38 MAPK signaling pathways and protected the liver against paracetamol-induced damage [0.03%]
檞皮素脂质体通过有效调控Nrf2/Keap1和NF-κB/p38MAPK信号通路保护肝脏免受对乙酰氨基酚损伤
Fatma El Zahraa A Elkady,Walaa A Moselhy,Fatma I Abo El-Ela et al.
Fatma El Zahraa A Elkady et al.
The prevalence of hepatotoxicity has sharply increased worldwide in recent decades. Our study aimed to enhance quercetin's effectiveness against paracetamol (PCM)-induced hepatotoxicity using a quercetin liposome nano formulation. The querc...
Transcriptomics analysis unveils the complex interplay between diabetes and hypertension in regulating renal cell carcinoma pathway followed by pancreatic metastasis [0.03%]
转录组分析揭示了糖尿病和高血压在调节肾细胞癌向胰腺转移的途径中的复杂相互作用
K M Tanjida Islam,Roksana Khanam,Aninda Roy et al.
K M Tanjida Islam et al.
Renal cell carcinoma (RCC) is often associated with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hypertension. While existing research has established connections between these metabolic conditions and RCC, the underlying...
Integrative analysis of transcriptomics and drug-target networks identifies SMN1 as a novel biomarker and therapeutic target for amyotrophic lateral sclerosis [0.03%]
整合转录组学和药物靶点网络的分析鉴定出SMN1是运动神经元疾病中的新型生物标志物和治疗靶点
Deboral Eshak,Mohanapriya Arumugam
Deboral Eshak
Amyotrophic lateral sclerosis (ALS) is a prevalent and debilitating neurodegenerative disorder characterized by the selective degeneration of motor neurons. This study aims to unravel the molecular mechanisms underlying ALS through an integ...
Evaluation of salinity tolerance of Egyptian barley genotypes and their dehydrin 6-based single nucleotide polymorphisms (SNPs) diversity [0.03%]
埃及 barley 品种耐盐性评价及其脱水素 6 基因单核苷酸多态性（SNP）多样性分析
Reda M Gaafar,Ismael A Khatab,Samah A Mariey
Reda M Gaafar
In many countries, freshwater sources for agricultural irrigation are scarce, making it challenging to meet the food production needs of the growing human population. Utilizing seawater for agriculture could be a potential solution for limi...