In-silico, in-vitro, and proteomics analyses on repurposed drugs in targeting the small GTPase, Rho subfamily protein (Rho GTPase), and putative Rho GTPase-activating protein (RhoGAP) of Giardia lamblia [0.03%]
针对兰伯贾第虫的小G蛋白、Rho亚家族蛋白（Rho GTP酶）和假定的Rho GTP酶激活蛋白（RhoGAP）的再利用药物的计算机模拟，体外及蛋白质组学分析
Nurhana Jasni,Khairul Bariyyah Abd Halim,Wong Weng Kin et al.
Nurhana Jasni et al.
Giardia lamblia is a globally prevalent protozoan responsible for Giardiasis, an intestinal disease commonly treated with nitroimidazoles such as metronidazole, tinidazole, and albendazole. However, increasing drug resistance has reduced tr...
Causal correlation between inflammatory cytokines and hypertrophic scar based on two-sample Mendelian randomization [0.03%]
基于两样本孟德尔随机化的炎症细胞因子与增生性疤痕的因果关联分析
Lujia Mao,Juan Huang,Yixun Zhang et al.
Lujia Mao et al.
Hypertrophic scars result from the abnormal proliferation of fibroblasts and the accumulation of collagen after skin injury. In this process, inflammatory cytokines act as crucial regulators. The large - scale release of inflammatory cytoki...
In-silico study on biomolecules derived from Cissus quadrangularis towards anti-inflammation [0.03%]
化学生物学中关于Cissus quadrangularis衍生生物分子抗炎性的研究
H Nilofer Farjana,G Mohan Valiathan,S Mohanasatheesh
H Nilofer Farjana
Objective: CD 163 protein is a macrophage-specific protein and hemoglobin scavenger receptor. Elevated expression of CD 163 protein in macrophages is an important feature indicating that tissues are subjected to inflammat...
Phenotyping analysis of rice cv. Nipponbare overexpressing OsMADS56 gene in drought tolerance, plant height, and yield components [0.03%]
OsMADS56基因过表达水稻品种nipponbare的抗旱性、株高和产量成分表型分析
Dini Nurdiani,Dwi Widyajayantie,Enung Sri Mulyaningsih et al.
Dini Nurdiani et al.
Background: The MADS-box protein family is a transcription factor (TF) family whose members harbour a MADS-box domain located in their N-terminal. This domain consists of 60 amino acids and functions in DNA binding. In pl...
Decoding the cannabis tissue culture puzzle: Machine learning analysis of cannabis in vitro morpho-physiological disorders expands the potential for precision micropropagation [0.03%]
解码大麻组织培养难题：机器学习分析大麻体外形态-生理异常现象，拓展精准微繁殖潜能
Marco Pepe,Mohsen Hesami,Kristian Adamek et al.
Marco Pepe et al.
Cannabis sativa L. (cannabis) has recently re-emerged as an economically important crop, fueling research focused on enhancing production practices to meet market demands. The developing cannabis industry can be improved by overcoming certa...
A metagenomic exploration of microbial distribution among the pond sediment, shrimp (Penaeus monodon) tissue and pond water: A special focus on nutrient cycling and shrimp viral pathogens [0.03%]
虾（斑节对虾）组织、 ponds 和养殖水体中微生物分布的元基因组研究：特别关注营养物质循环和 shrimp 病毒病原体
Avik Sarkar,Rakesh Kr Patra,Mathavan Muthaiyan et al.
Avik Sarkar et al.
Penaeus monodon, a major shrimp species cultivated in Eastern Asia, has faced setbacks in aquaculture due to disease outbreaks. Metagenomic studies offer insights into the pond microbiome, revealing its critical roles in nutrient cycling, w...
Fmp45 promotes Rad53 dephosphorylation via Ptc2 interaction to attenuate checkpoint signaling and maintain genome stability [0.03%]
FMP45通过与Ptc2相互作用促进Rad53去磷酸化以削弱检查点信号并维持基因组稳定性
Zhongyi Cong,Jingyuan Jiang,Mengyuan Li et al.
Zhongyi Cong et al.
Background: Double-strand breaks (DSBs) are repaired through the coordinated action of DNA damage checkpoint pathways, homologous recombination (HR), and non-homologous end joining (NHEJ) mechanisms. Given the complexity ...
Loss-of-function variant of SLC30A8 rs13266634 (C > T) protects against type 2 diabetes by stabilizing ZnT8: Insights from epidemiological and computational analyses [0.03%]
SLC30A8rs13266634(C>T)失活变异通过稳定ZnT8以对抗2型糖尿病的作用：来自流行病学和计算分析的见解
Nilima Barman,M Atiqul Haque,Md Ridwan et al.
Nilima Barman et al.
The loss-of-function variant rs13266634 (C > T) in SLC30A8 has been linked to type-2-diabetes (T2D) susceptibility with conflicting findings. We investigated its role among T2D patients of Bangladesh. The rs13266634 (C > T) variant results ...
Enzymatic characterization and proteomic profiling of venoms from the medically important Androctonus species [0.03%]
药用重要物种Androctonus毒素的酶学表征及蛋白质组分析
Alhussin M A Megaly,Masahiro Miyashita,Abdulaziz R Alqahtani et al.
Alhussin M A Megaly et al.
Egyptian scorpions of the Androctonus genus (family Buthidae) produce life-threatening stings owing to their neurotoxic venom. However, the composition and enzymatic activities of their venoms remain poorly understood: We used electrophores...
Comprehensive examination of demographic, psychological, cognitive, biochemical, and genetic profiles of methamphetamine addicts [0.03%]
对甲基苯丙胺成瘾者进行人口学、心理、认知、生化及遗传特征的综合研究
Haider K Hussain,Yolanda Loarce Tejada,Anna Barbaro
Haider K Hussain
Methamphetamine (MA) addiction is a serious public health concern with wide-ranging neurobiological and behavioral effects. This study aimed to assess the demographic, psychological, cognitive, biochemical, and genetic profiles of individua...