The role of dicentric chromosome formation and secondary centromere deletion in the evolution of myeloid malignancy [0.03%]
dicentric染色体形成和次要着丝粒缺失在髓系恶性肿瘤进化中的作用
Ruth N Mackinnon,Lynda J Campbell
Ruth N Mackinnon
Dicentric chromosomes have been identified as instigators of the genome instability associated with cancer, but this instability is often resolved by one of a number of different secondary events. These include centromere inactivation, inve...
Spatial Organization and Dynamics of Transcription Elongation and Pre-mRNA Processing in Live Cells [0.03%]
活细胞中转录延长和前信使rna处理的时空组织及动态变化
Miguel Sánchez-Álvarez,Noemí Sánchez-Hernández,Carlos Suñé
Miguel Sánchez-Álvarez
During the last 30 years, systematic biochemical and functional studies have significantly expanded our knowledge of the transcriptional molecular components and the pre-mRNA processing machinery of the cell. However, our current understand...
Histone Chaperones Spt6 and FACT: Similarities and Differences in Modes of Action at Transcribed Genes [0.03%]
组蛋白伴侣Spt6和FACT在转录基因上的作用机制的异同点
Andrea A Duina
Andrea A Duina
The process of gene transcription requires the participation of a large number of factors that collectively promote the accurate and efficient expression of an organism's genetic information. In eukaryotic cells, a subset of these factors c...
Bartlomiej Bartkowiak,April L Mackellar,Arno L Greenleaf
Bartlomiej Bartkowiak
Eukaryotic RNA polymerase II (RNAPII) not only synthesizes mRNA but also coordinates transcription-related processes via its unique C-terminal repeat domain (CTD). The CTD is an RNAPII-specific protein segment consisting of repeating heptad...
Molecular investigation of pediatric portuguese patients with sensorineural hearing loss [0.03%]
葡萄牙儿童神经感觉性听力损失的分子机制研究
Célia Nogueira,Miguel Coutinho,Cristina Pereira et al.
Célia Nogueira et al.
The understanding of the molecular genetics in sensorineural hearing loss (SNHL) has advanced rapidly during the last decade, but the molecular etiology of hearing impairment in the Portuguese population has not been investigated thoroughly...
Jeremy R Shearman,Alan N Wilton
Jeremy R Shearman
The unique breeding structure of the domestic dog makes canine genetics a useful tool to further the understanding of inherited diseases and gene function. Answers to the questions of when and where the dog was domesticated from the wolf ar...
Comparative Study of Cyanobacterial and E. coli RNA Polymerases: Misincorporation, Abortive Transcription, and Dependence on Divalent Cations [0.03%]
关于蓝藻和E.coli的RNA聚合酶的比较研究：错配插入、无效转录及二价阳离子依赖性
Masahiko Imashimizu,Kan Tanaka,Nobuo Shimamoto
Masahiko Imashimizu
If Mg(2+) ion is replaced by Mn(2+) ion, RNA polymerase tends to misincorporate noncognate nucleotide, which is thought to be one of the reasons for the toxicity of Mn(2+) ion. Therefore, most cells have Mn(2+) ion at low intracellular conc...
Jun Nishio,Hiroshi Iwasaki,Kazuki Nabeshima et al.
Jun Nishio et al.
Myxoid soft-tissue sarcomas represent a heterogeneous group of mesenchymal tumors characterized by a predominantly myxoid matrix, including myxoid liposarcoma (MLS), low-grade fibromyxoid sarcoma (LGFMS), extraskeletal myxoid chondrosarcoma...
Investigation of Differences in P53 Gene Polymorphisms between Schizophrenia and Lung Cancer Patients in the Turkish Population [0.03%]
土耳其人群中精神分裂症和肺癌患者P53基因多态性差异的研究
Ulku Ozbey,Hüseyin Yüce,Mustafa Namli et al.
Ulku Ozbey et al.
Objective. The reduced incidence of cancer observed in schizophrenia patients may be related to differences in genetic background. It has been suggested that genetic predisposition towards schizophrenia is associated with reduced vulnerabil...
Characterization and In Silico Analysis of Pregnancy-Associated Glycoprotein-1 Gene of Buffalo (Bubalus bubalis) [0.03%]
水牛（Bubalus bubalis）妊娠相关糖蛋白-1基因的鉴定及生物信息学分析
Jerome A,S K Singh,S K Agarwal et al.
Jerome A et al.
Pregnancy-Associated Glycoproteins (PAGs) are trophoblastic proteins belonging to the Aspartic proteinase family secreted by different placental cells of many mammalian species. They play a pivotal role in placentogenesis, foetomaternal uni...