Highly effective gene transfection in vivo by alkylated polyethylenimine [0.03%]
通过烷基化聚乙烯亚胺实现高效的体内基因转染
Jennifer A Fortune,Tatiana I Novobrantseva,Alexander M Klibanov
Jennifer A Fortune
We mechanistically explored the effect of increased hydrophobicity of the polycation on the efficacy and specificity of gene delivery in mice. N-Alkylated linear PEIs with varying alkyl chain lengths and extent of substitution were synthesi...
Effects of polyethylene glycol spacer length and ligand density on folate receptor targeting of liposomal Doxorubicin in vitro [0.03%]
聚乙二醇连接臂长度和配体密度对靶向叶酸受体的脂质体多柔比星的体内作用的影响
Kumi Kawano,Yoshie Maitani
Kumi Kawano
The folate receptor is an attractive target for selective tumor delivery of liposomal doxorubicin (DXR) because it is abundantly expressed in a large percentage of tumors. This study examined the effect of polyethylene glycol (PEG) spacer l...
Liposomal Tumor Targeting in Drug Delivery Utilizing MMP-2- and MMP-9-Binding Ligands [0.03%]
利用MMP-2和MMP-9结合配体的脂质体肿瘤靶向给药系统
Oula Penate Medina,Merja Haikola,Marja Tahtinen et al.
Oula Penate Medina et al.
Nanotechnology offers an alternative to conventional treatment options by enabling different drug delivery and controlled-release delivery strategies. Liposomes being especially biodegradable and in most cases essentially nontoxic offer a v...