Active Targeting to Osteosarcoma Cells and Apoptotic Cell Death Induction by the Novel Lectin Eucheuma serra Agglutinin Isolated from a Marine Red Alga [0.03%]
新型海洋褐藻石花菜凝集素对成骨细胞瘤的主动靶向及诱导凋亡作用研究
Keita Hayashi,Peter Walde,Tatsuhiko Miyazaki et al.
Keita Hayashi et al.
Previously, we demonstrated that the novel lectin Eucheuma serra agglutinin from a marine red alga (ESA) induces apoptotic cell death in carcinoma. We now find that ESA induces apoptosis also in the case of sarcoma cells. First, propidium i...
Application of ferriferous oxide modified by chitosan in gene delivery [0.03%]
壳聚糖改性铁基磁性氧化物基因载体的研究进展
Yu Kuang,Tun Yuan,Zhongwei Zhang et al.
Yu Kuang et al.
New approaches to improve the traditional gene carriers are still required. Here we explore Fe(3)O(4) modified with degradable polymers that enhances gene delivery and target delivery using permanent magnetic field. Two magnetic Fe(3)O(4) n...
Chlorotoxin Fused to IgG-Fc Inhibits Glioblastoma Cell Motility via Receptor-Mediated Endocytosis [0.03%]
氯毒素与IgG-Fc融合通过受体介导的胞吞作用抑制胶质母细胞瘤细胞运动性
Tomonari Kasai,Keisuke Nakamura,Arun Vaidyanath et al.
Tomonari Kasai et al.
Chlorotoxin is a 36-amino acid peptide derived from Leiurus quinquestriatus (scorpion) venom, which has been shown to inhibit low-conductance chloride channels in colonic epithelial cells. Chlorotoxin also binds to matrix metalloproteinase-...
Daniela De Stefano,Rosa Carnuccio,Maria Chiara Maiuri
Daniela De Stefano
In the last decade, the nanotechnology advancement has developed a plethora of novel and intriguing nanomaterial application in many sectors, including research and medicine. However, many risks have been highlighted in their use, particula...
Application of Collagen-Model Triple-Helical Peptide-Amphiphiles for CD44-Targeted Drug Delivery Systems [0.03%]
一种用于CD44靶向药物传输系统的胶原模型三螺旋肽两性分子的研究及其应用
Margaret W Ndinguri,Alexander Zheleznyak,Janelle L Lauer et al.
Margaret W Ndinguri et al.
Cancer treatment by chemotherapy is typically accompanied by deleterious side effects, attributed to the toxic action of chemotherapeutics on proliferating cells from nontumor tissues. The cell surface proteoglycan CD44 has been recognized ...
Duncan Ayers,Alessandro Nasti
Duncan Ayers
The implementation of cytotoxic chemotherapeutic drugs in the fight against cancer has played an invariably essential role for minimizing the extent of tumour progression and/or metastases in the patient and thus allowing for longer event f...
Intracellular Delivery of siRNA by Polycationic Superparamagnetic Nanoparticles [0.03%]
多阳离子超顺磁性纳米颗粒递送siRNA进入细胞内
Betzaida Castillo,Lev Bromberg,Xaira López et al.
Betzaida Castillo et al.
The siRNA transfection efficiency of nanoparticles (NPs), composed of a superparamagnetic iron oxide core modified with polycationic polymers (poly(hexamethylene biguanide) or branched polyethyleneimine), were studied in CHO-K1 and HeLa cel...
Composite polylactic-methacrylic Acid copolymer nanoparticles for the delivery of methotrexate [0.03%]
用于递送甲氨蝶呤的聚乳酸-丙烯酸共聚物复合纳米颗粒
Bongani Sibeko,Yahya E Choonara,Lisa C du Toit et al.
Bongani Sibeko et al.
The purpose of this study was to develop poly(lactic acid)-methacrylic acid copolymeric nanoparticles with the potential to serve as nanocarrier systems for methotrexate (MTX) used in the chemotherapy of primary central nervous system lymph...
Jae-Hwan Lee,Ramana M Pidaparti,Gary M Atkinson et al.
Jae-Hwan Lee et al.
Ocular diseases, such as, glaucoma, age-related macular degeneration (AMD), diabetic retinopathy, and retinitis pigmentosa require drug management in order to prevent blindness and affecting million of adults in USA and worldwide. There is ...
In vitro investigation of a terbinafine impregnated subcutaneous implant for veterinary use [0.03%]
伏立康唑缓释植入剂的体外研究
M J Souza,T Cairns,J Yarbrogh et al.
M J Souza et al.
A terbinafine impregnated subcutaneous implant was evaluated to determine if drug was released into isotonic saline over the course of 6 months at two different temperatures, 37°C and 4°C. These temperatures were chosen to simulate the no...