Gyan P Mishra,Mahuya Bagui,Viral Tamboli et al.
Gyan P Mishra et al.
Liposomal formulations were significantly explored over the last decade for the ophthalmic drug delivery applications. These formulations are mainly composed of phosphatidylcholine (PC) and other constituents such as cholesterol and lipid-c...
A novel domperidone hydrogel: preparation, characterization, pharmacokinetic, and pharmacodynamic properties [0.03%]
一种新型多潘立酮凝胶的制备、表征及其药代动力学和药效学性质研究
Chun-Hui Zhang,Bing-Xiang Zhao,Yue Huang et al.
Chun-Hui Zhang et al.
The purpose of the present study was to prepare a novel domperidone hydrogel. The domperidone dispersion was prepared by the solvent evaporation method. The characteristics of domperidone dispersion were measured by dynamic light scattering...
A liposomal formulation able to incorporate a high content of Paclitaxel and exert promising anticancer effect [0.03%]
一种能够大量包载紫杉醇并发挥良好抗癌作用的脂质体递送系统
Pei Kan,Chih-Wan Tsao,Ae-June Wang et al.
Pei Kan et al.
A liposome formulation for paclitaxel was developed in this study. The liposomes, composed of naturally unsaturated and hydrogenated phosphatidylcholines, with significant phase transition temperature difference, were prepared and character...
Andreas Wagner,Karola Vorauer-Uhl
Andreas Wagner
Liposomes, spherical vesicles consisting of one or more phospholipid bilayers, were first described in the mid 60s by Bangham and coworkers. Since then, liposomes have made their way to the market. Today, numerous lab scale but only a few l...
The impact of dosing interval in a novel tandem oral dosing strategy: enhancing the exposure of low solubility drug candidates in a preclinical setting [0.03%]
新型口服给药策略中给药间隔的影响：在临床前设置中增强低溶解性药物候选物的暴露量
Po-Chang Chiang,Sarah A South,Steve P Wene
Po-Chang Chiang
In drug discovery, time and resource constraints necessitate increasingly early decision making to accelerate or stop preclinical programs. Early discovery drug candidates may be potent inhibitors of new targets, but all too often exhibit p...
In Vitro Gene Delivery Mediated by Asialofetuin-Appended Cationic Liposomes Associated with γ-Cyclodextrin into Hepatocytes [0.03%]
N-去唾液酸卵清蛋白结合的携带γ-环糊精的阳离子脂质体介导的肝细胞基因传递
Keiichi Motoyama,Yoshihiro Nakashima,Yukihiko Aramaki et al.
Keiichi Motoyama et al.
The purpose of this study is to evaluate in vitro gene delivery mediated by asialofetuin-appended cationic liposomes (AF-liposomes) associating cyclodextrins (CyD/AF-liposomes) as a hepatocyte-selective nonviral vector. Of various CyDs, AF-...
Tumor suppressor gene-based nanotherapy: from test tube to the clinic [0.03%]
基于肿瘤抑制基因的纳米治疗：从试管试验到临床应用
Manish Shanker,Jiankang Jin,Cynthia D Branch et al.
Manish Shanker et al.
Cancer is a major health problem in the world. Advances made in cancer therapy have improved the survival of patients in certain types of cancer. However, the overall five-year survival has not significantly improved in the majority of canc...
Characterization and In Vitro Skin Permeation of Meloxicam-Loaded Liposomes versus Transfersomes [0.03%]
布洛昔康载药脂质体和转移体的表征及体外透皮研究
Sureewan Duangjit,Praneet Opanasopit,Theerasak Rojanarata et al.
Sureewan Duangjit et al.
The goal of this study was to develop and evaluate the potential use of liposome and transfersome vesicles in the transdermal drug delivery of meloxicam (MX). MX-loaded vesicles were prepared and evaluated for particle size, zeta potential,...
Antibody-Hapten Recognition at the Surface of Functionalized Liposomes Studied by SPR: Steric Hindrance of Pegylated Phospholipids in Stealth Liposomes Prepared for Targeted Radionuclide Delivery [0.03%]
基于SPR的表面功能化脂质体上抗原-半抗原识别研究：PEG修饰脂质体的空间位阻效应及其在放射性靶向药物传递中的应用
Eliot P Botosoa,Mike Maillasson,Marie Mougin-Degraef et al.
Eliot P Botosoa et al.
Targeted PEGylated liposomes could increase the amount of drugs or radionuclides delivered to tumor cells. They show favorable stability and pharmacokinetics, but steric hindrance of the PEG chains can block the binding of the targeting moi...
Daniel A Balazs,Wt Godbey
Daniel A Balazs
Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures. These arrangements can be found in many shapes and sizes depending on lipid co...