Encapsulation of Protein-Polysaccharide HIP Complex in Polymeric Nanoparticles [0.03%]
蛋白质多糖HIP复合物的聚合物纳米粒子封装技术
Ripal Gaudana,Varun Khurana,Ashwin Parenky et al.
Ripal Gaudana et al.
The objective of the present study is to formulate and characterize a nanoparticulate-based formulation of a macromolecule in a hydrophobic ion pairing (HIP) complex form. So far, HIP complexation approach has been studied only for proteins...
Unveiling Stability Criteria of DNA-Carbon Nanotubes Constructs by Scanning Tunneling Microscopy and Computational Modeling [0.03%]
基于扫描隧道显微镜和计算模型的DNA-碳纳米管体系稳定性的研究
Svetlana Kilina,Dzmitry A Yarotski,A Alec Talin et al.
Svetlana Kilina et al.
We present a combined approach that relies on computational simulations and scanning tunneling microscopy (STM) measurements to reveal morphological properties and stability criteria of carbon nanotube-DNA (CNT-DNA) constructs. Application ...
Preparation and Characterization of Stealth Archaeosomes Based on a Synthetic PEGylated Archaeal Tetraether Lipid [0.03%]
基于合成聚乙二醇化古菌四醚脂质的隐形考古索omes的制备及表征
Julie Barbeau,Sandrine Cammas-Marion,Pierrick Auvray et al.
Julie Barbeau et al.
The present studies were focused on the formation and characterization of sterically stabilized archaeosomes made from a synthetic PEGylated archaeal lipid. In a first step, a synthetic archaeal tetraether bipolar lipid was functionalized w...
Local gene delivery system by bubble liposomes and ultrasound exposure into joint synovium [0.03%]
载基因脂泡联合超声波作用于滑膜局部给药系统研究
Yoichi Negishi,Yuka Tsunoda,Yoko Endo-Takahashi et al.
Yoichi Negishi et al.
Recently, we have developed novel polyethylene glycol modified liposomes (bubble liposomes; BL) entrapping an ultrasound (US) imaging gas, which can work as a gene delivery tool with US exposure. In this study, we investigated the usefulnes...
Kunikazu Moribe,Waree Limwikrant,Kenjirou Higashi et al.
Kunikazu Moribe et al.
Drug nanoparticle formulation using ascorbic acid derivatives and its therapeutic uses have recently been introduced. Hydrophilic ascorbic acid derivatives such as ascorbyl glycoside have been used not only as antioxidants but also as food ...
Nanoprodrugs of NSAIDs: Preparation and Characterization of Flufenamic Acid Nanoprodrugs [0.03%]
非甾体抗炎药纳米前药：氟芬那酸纳米前药的制备与表征
Bong-Seop Lee,Chi Woo Yoon,Arsen Osipov et al.
Bong-Seop Lee et al.
We demonstrated that hydrophobic derivatives of the nonsteroidal anti-inflammatory drug (NSAID)flufenamic acid (FA), can be formed into stable nanometer-sized prodrugs (nanoprodrugs) that inhibit the growth of glioma cells, suggesting their...
Cellular Injury of Cardiomyocytes during Hepatocyte Growth Factor Gene Transfection with Ultrasound-Triggered Bubble Liposome Destruction [0.03%]
超声波触发微泡脂质体破裂介导肝细胞生长因子基因转染对心肌细胞的损伤效应
Kazuo Komamura,Rie Tatsumi,Yuko Tsujita-Kuroda et al.
Kazuo Komamura et al.
We transfected naked HGF plasmid DNA into cultured cardiomyocytes using a sonoporation method consisting of ultrasound-triggered bubble liposome destruction. We examined the effects on transfection efficiency of three concentrations of bubb...
Ciara Kelly,Caroline Jefferies,Sally-Ann Cryan
Ciara Kelly
As the role of monocytes and macrophages in a range of diseases is better understood, strategies to target these cell types are of growing importance both scientifically and therapeutically. As particulate carriers, liposomes naturally targ...
A review on composite liposomal technologies for specialized drug delivery [0.03%]
复合脂质体技术的评论：用于专门的药物输送
Maluta S Mufamadi,Viness Pillay,Yahya E Choonara et al.
Maluta S Mufamadi et al.
The combination of liposomes with polymeric scaffolds could revolutionize the current state of drug delivery technology. Although liposomes have been extensively studied as a promising drug delivery model for bioactive compounds, there stil...
Liposome Model Systems to Study the Endosomal Escape of Cell-Penetrating Peptides: Transport across Phospholipid Membranes Induced by a Proton Gradient [0.03%]
用于研究细胞穿透肽胞内体逃逸的脂osomes模型体系：由质子梯度引发的通过磷脂膜的转运
Fatemeh Madani,Alex Perálvarez-Marín,Astrid Gräslund
Fatemeh Madani
Detergent-mediated reconstitution of bacteriorhodopsin (BR) into large unilamellar vesicles (LUVs) was investigated, and the effects were carefully characterized for every step of the procedure. LUVs were prepared by the extrusion method, a...