Preparation of a Nanoscaled Poly(vinyl alcohol)/Hydroxyapatite/DNA Complex Using High Hydrostatic Pressure Technology for In Vitro and In Vivo Gene Delivery [0.03%]
利用高压技术制备纳米级聚乙烯醇/羟基磷灰石/DNA复合材料进行体内外基因传递研究
Tsuyoshi Kimura,Yoichi Nibe,Seiichi Funamoto et al.
Tsuyoshi Kimura et al.
Our previous research showed that poly(vinyl alcohol) (PVA) nanoparticles incorporating DNA with hydrogen bonds obtained by high hydrostatic pressurization are able to deliver DNA without any significant cytotoxicity. To enhance transfectio...
Tomoko Ito,Koyuki Ibe,Tomohiro Uchino et al.
Tomoko Ito et al.
Biocompatible DNA/gold nanoparticle complex with a protective calcium phosphate (CaP) coating was prepared by incubating DNA/gold nanoparticle complex coated by hyaluronic acid in SBF (simulated body fluid) with a Ca concentration above 2 m...
Prophylaxis of postoperative nausea and vomiting in adolescent patients: a review with emphasis on combination of fixed-dose ondansetron and transdermal scopolamine [0.03%]
青少年患者术后恶心呕吐的预防：固定剂量昂丹司琼联合贴皮山莨菪素治疗的 meta 分析
Joseph V Pergolizzi,Robert Raffa,Robert Taylor
Joseph V Pergolizzi
Postoperative nausea and vomiting (PONV) is a relatively common occurrence (20-30%) that delays discharge and, if persistent, can lead to serious complications. The incidence of PONV is a function of patient characteristics, the type and du...
Modeling the release kinetics of poorly water-soluble drug molecules from liposomal nanocarriers [0.03%]
模拟脂质纳米载体中药效分子的释放动力学
Stephan Loew,Alfred Fahr,Sylvio May
Stephan Loew
Liposomes are frequently used as pharmaceutical nanocarriers to deliver poorly water-soluble drugs such as temoporfin, cyclosporine A, amphotericin B, and paclitaxel to their target site. Optimal drug delivery depends on understanding the r...
The use of radioactive marker as a tool to evaluate the drug release in plasma and particle biodistribution of block copolymer nanoparticles [0.03%]
放射性标记物在评估嵌段共聚物纳米粒的药物释放和颗粒生物分布方面的应用
Sharon Johnstone,Steven Ansell,Sherwin Xie et al.
Sharon Johnstone et al.
Diblock copolymer nanoparticles encapsulating a paclitaxel prodrug, Propac 7, have been used to demonstrate the usefulness of a nonmetabolizable radioactive marker, cholesteryl hexadecyl ether (CHE), to evaluate nanoparticle formulation var...
High-Resolution Imaging of Dendrimers Used in Drug Delivery via Scanning Probe Microscopy [0.03%]
利用扫描探针显微镜对药物传递用超支化聚合物的高分辨率成像研究
Lifang Shi,Christopher J Fleming,Shawn L Riechers et al.
Lifang Shi et al.
Dendrimers and telodendrimer micelles represent two new classes of vehicles for drug delivery that have attracted much attention recently. Their structural characterization at the molecular and submolecular level remains a challenge due to ...
Effective Delivery of PEGylated siRNA-Containing Lipoplexes to Extraperitoneal Tumours following Intraperitoneal Administration [0.03%]
经腹腔给药后有效向腹膜外肿瘤递送含PEG化siRNA的脂质plexes
Akul Singhania,Sherry Y Wu,Nigel A J McMillan
Akul Singhania
Intraperitoneal (i.p.) administration of small interfering RNA (siRNA) has, to date, shown promise in treating tumours located within the peritoneal cavity. The ability of these siRNA molecules to reach extraperitoneal tumours following i.p...
An overview on the field of micro- and nanotechnologies for synthetic Peptide-based vaccines [0.03%]
基于合成肽的微纳米疫苗技术进展综述
Aiala Salvador,Manoli Igartua,Rosa Maria Hernández et al.
Aiala Salvador et al.
The development of synthetic peptide-based vaccines has many advantages in comparison with vaccines based on live attenuated organisms, inactivated or killed organism, or toxins. Peptide-based vaccines cannot revert to a virulent form, allo...
Enhanced Transport Capabilities via Nanotechnologies: Impacting Bioefficacy, Controlled Release Strategies, and Novel Chaperones [0.03%]
纳米技术改善药物传输能力：提高生物药效、控制释放策略及全新分子伴侣
Thomai Panagiotou,Robert J Fisher
Thomai Panagiotou
Emerging nanotechnologies have, and will continue to have, a major impact on the pharmaceutical industry. Their influence on a drug's life cycle, inception to delivery, is rapidly expanding. As the industry moves more aggressively toward co...
Transplantation of porcine hepatocytes cultured with polylactic Acid-o-carboxymethylated chitosan nanoparticles promotes liver regeneration in acute liver failure rats [0.03%]
聚乳酸-O-羧甲基壳聚糖纳米粒培养的猪肝细胞移植促进急性肝衰竭大鼠肝脏再生
Zhong Chen,Renan Chang,Weijun Guan et al.
Zhong Chen et al.
In this study, free porcine hepatocytes suspension (Group A), porcine hepatocytes embedded in collagen gel (Group B), porcine hepatocytes cultured with PLA-O-CMC nanoparticles and embedded in collagen gel (Group C), and PLA-O-CMC nanopartic...