A new application of lipid nanoemulsions as coating agent, providing zero-order hydrophilic drug release from tablets [0.03%]
一种新型脂质纳米乳液作为包衣剂的应用，可使片剂实现零级释放亲水性药物
Nicolas Anton,Astrid de Crevoisier,Sabrina Schmitt et al.
Nicolas Anton et al.
The objective of the present investigation was to evaluate potential of nanoemulsions as a coating material for the tablets. The nanoemulsion of size less than 100 nm was prepared using a simple and low-energy spontaneous emulsification met...
Development, characterization, and in vitro evaluation of tamoxifen microemulsions [0.03%]
开发、表征及体外评价他莫昔芬微乳体系的研究
E Monteagudo,Y Gándola,L González et al.
E Monteagudo et al.
Microemulsions (MEs) were designed by an innovative rational development, characterized, and used to load up to 20 mM of Tamoxifen citrate (TMX). They were made with acceptable and well-characterized excipients for all the routes of adminis...
Liposomes for Targeted Delivery of Active Agents against Neurodegenerative Diseases (Alzheimer's Disease and Parkinson's Disease) [0.03%]
针对神经退行性疾病（阿尔茨海默病和帕金森病）活性药物靶向递送的脂质体
Carlos Spuch,Carmen Navarro
Carlos Spuch
Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease represent a huge unmet medical need. The prevalence of both diseases is increasing, but the efficacy of treatment is still very limited due to various factors i...
Cationic albumin nanoparticles for enhanced drug delivery to treat breast cancer: preparation and in vitro assessment [0.03%]
用于治疗乳腺癌的增强型药物递送阳离子白蛋白纳米粒子：制备和体外评估
Sana Abbasi,Arghya Paul,Wei Shao et al.
Sana Abbasi et al.
Most anticancer drugs are greatly limited by the serious side effects that they cause. Doxorubicin (DOX) is an antineoplastic agent, commonly used against breast cancer. However, it may lead to irreversible cardiotoxicity, which could even ...
Optimization of liposomal lipid composition for a new, reactive sulfur donor, and in vivo efficacy studies on mice to antagonize cyanide intoxication [0.03%]
用于新的供硫型脂质体的优化配方以及在小鼠体内拮抗氰化物中毒的作用研究
Ilona Petrikovics,Prashanth Jayanna,Jonathan Childress et al.
Ilona Petrikovics et al.
Present studies have focused on a novel cyanide antidotal system, on the coencapsulation of a new sulfur donor DTO with rhodanese within sterically stabilized liposomes. The optimal lipid composition for coencapsulation of DTO with rhodanes...
IT-141, a Polymer Micelle Encapsulating SN-38, Induces Tumor Regression in Multiple Colorectal Cancer Models [0.03%]
一种聚合物胶束包载伊立替康衍生物SN-38的新型制剂在多个结直肠癌模型中诱导肿瘤消退（IT-141）
Adam Carie,Jonathan Rios-Doria,Tara Costich et al.
Adam Carie et al.
Polymer micelles are promising drug delivery vehicles for the delivery of anticancer agents to tumors. Often, anticancer drugs display potent cytotoxic effects towards cancer cells but are too hydrophobic to be administered in the clinic as...
Effects of Selected Anionic β-Cyclodextrins on Persistence of Blood Glucose Lowering by Insulin Glargine after Subcutaneous Injection to Rats [0.03%]
几种阴离子β-环糊精对拉 glu 注射到大鼠皮下后胰岛素 glargine 血糖降低持久性的影响
Keiko Uehata,Takayuki Anno,Kayoko Hayashida et al.
Keiko Uehata et al.
Insulin glargine is a synthetic long-acting insulin product used for patients with diabetes mellitus. In this study, to obtain the further desirable blood-glucose lowering profile of insulin glargine, we investigated the effects of β-cyclo...
Current State-of-Art and New Trends on Lipid Nanoparticles (SLN and NLC) for Oral Drug Delivery [0.03%]
口服药物递送用脂质纳米颗粒(SLN和NLC)的研究现状及新趋势
Patrícia Severino,Tatiana Andreani,Ana Sofia Macedo et al.
Patrícia Severino et al.
Lipids and lipid nanoparticles are extensively employed as oral-delivery systems for drugs and other active ingredients. These have been exploited for many features in the field of pharmaceutical technology. Lipids usually enhance drug abso...
Lipid nanocapsule-based gels for enhancement of transdermal delivery of ketorolac tromethamine [0.03%]
用于佐米特罗洛酸 Tromethamine 经皮给药的脂质纳米胶囊基凝胶的增强剂
Jaleh Varshosaz,Valiollah Hajhashemi,Sindokht Soltanzadeh
Jaleh Varshosaz
Previous reports show ineffective transdermal delivery of ketorolac by nanostructured lipid carriers (NLCs). The aim of the present work was enhancement of transdermal delivery of ketorolac by another colloidal carriers, lipid nanocapsules ...
The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain Barrier [0.03%]
用于跨越血脑屏障的非病毒基因转移的特洛伊木马脂质体技术
Ruben J Boado,William M Pardridge
Ruben J Boado
The application of blood-borne gene therapy protocols to the brain is limited by the presence of the blood-brain barrier (BBB). Viruses have been extensively used as gene delivery systems. However, their efficacy in brain is limited by the ...