Microfabricated engineered particle systems for respiratory drug delivery and other pharmaceutical applications [0.03%]
用于呼吸道药物输送和其他制药应用的微工程粒子系统
Andres Garcia,Peter Mack,Stuart Williams et al.
Andres Garcia et al.
Particle Replication in Non-Wetting Templates (PRINT(®)) is a platform particle drug delivery technology that coopts the precision and nanoscale spatial resolution inherently afforded by lithographic techniques derived from the microelectr...
Adsorption and desorption of bioactive proteins on hydroxyapatite for protein delivery systems [0.03%]
生物活性蛋白质在羟基磷灰石上的吸附与解吸用于蛋白质输送系统
Chie Kojima,Kenji Watanabe
Chie Kojima
Hydroxyapatite (HA) is a precursor of bone and has been studied as a biomaterial. We attempted HA to apply to protein delivery systems. In this study, the association and dissociation properties of two types of bioactive proteins, cytochrom...
PLGA Nanoparticles for Ultrasound-Mediated Gene Delivery to Solid Tumors [0.03%]
用于实体瘤的超声介导基因传递的 PLGA 纳米粒子
Marxa Figueiredo,Rinat Esenaliev
Marxa Figueiredo
This paper focuses on novel approaches in the field of nanotechnology-based carriers utilizing ultrasound stimuli as a means to spatially target gene delivery in vivo, using nanoparticles made with either poly(lactic-co-glycolic acid) (PLGA...
Successfully improving ocular drug delivery using the cationic nanoemulsion, novasorb [0.03%]
阳离子型纳米乳剂novasorb在改善眼部药物递送方面的研究进展得成功
Frederic Lallemand,Philippe Daull,Simon Benita et al.
Frederic Lallemand et al.
Topical ophthalmic delivery of active ingredients can be achieved using cationic nanoemulsions. In the last decade, Novagali Pharma has successfully developed and marketed Novasorb, an advanced pharmaceutical technology for the treatment of...
Design and characterization of a silk-fibroin-based drug delivery platform using naproxen as a model drug [0.03%]
以萘普生作为模型药物的丝素基药物递送平台的设计与表征
Tatyana Dyakonov,Chue Hue Yang,Derek Bush et al.
Tatyana Dyakonov et al.
The objective of this proof-of-concept study was to develop a platform for controlled drug delivery based on silk fibroin (SF) and to explore the feasibility of using SF in oral drug delivery. The SF-containing matrixes were prepared via sp...
Valentina Morigi,Alessandro Tocchio,Carlo Bellavite Pellegrini et al.
Valentina Morigi et al.
Born from the marriage of nanotechnology and medicine, nanomedicine is set to bring advantages in the fight against unmet diseases. The field is recognized as a global challenge, and countless worldwide research and business initiatives are...
Effects of atelocollagen formulation containing oligonucleotide on endothelial permeability [0.03%]
寡核苷酸胶原蛋白制剂对血管内皮通透性的影响
Koji Hanai,Takashi Kojima,Mika Ota et al.
Koji Hanai et al.
Atelocollagen is a major animal protein that is used as a highly biocompatible biomaterial. To date, atelocollagen has been used as an effective drug delivery technology to sustain the release of antitumor proteins and to enhance the antitu...
Sarah Brown,David R Khan
Sarah Brown
Liposome-based chemotherapeutics used in the treatment of breast cancer can in principle enhance the therapeutic index of otherwise unencapsulated anticancer drugs. This is partially attributed to the fact that encapsulation of cytotoxic ag...
Cyclodextrin-containing polymers: versatile platforms of drug delivery materials [0.03%]
含环糊精的聚合物：药物递送材料的多功能平台
Jeremy D Heidel,Thomas Schluep
Jeremy D Heidel
Nanoparticles are being widely explored as potential therapeutics for numerous applications in medicine and have been shown to significantly improve the circulation, biodistribution, efficacy, and safety profiles of multiple classes of drug...
The Safety of EXPAREL ® (Bupivacaine Liposome Injectable Suspension) Administered by Peripheral Nerve Block in Rabbits and Dogs [0.03%]
考比卡因脂质体注射悬浊液（EXPAREL）经周围神经阻滞给药的兔和犬安全性研究
Brigitte M Richard,Paul Newton,Laura R Ott et al.
Brigitte M Richard et al.
A sustained-release DepoFoam injection formulation of bupivacaine (EXPAREL, 15 mg/mL) is currently being investigated for postsurgical analgesia via peripheral nerve block (PNB). Single-dose toxicology studies of EXPAREL (9, 18, and 30 mg/k...